沙门菌VI型分泌系统组装、结构特征和分泌调控网络的研究进展

doi:10.11843/j.issn.0366-6964.2023.06.005

Abstract

Abstract: Type VI secretion system (T6SS) is a widespread "secretion device" and "killing machine" in Gram-negative bacteria, which transmits bacterial toxins to prokaryotic or eukaryotic cells to inhibit or kill them. T6SS plays an important role in the pathogenic process of Salmonella, it can independently code five sets of T6SSs (T6SS-1-T6SS-5), which are respectively coded by Salmonella pathogenicity island 6 (SPI-6), SPI-19, SPI-20, SPI-21, and SPI-22. In addition, T6SS participates in the interspecific competition of Salmonella, biofilm formation, metal ion uptake and transportation, and interaction with host cells, playing an essential role in the life cycle of Salmonella. This article mainly reviews the assembly, genomic structural characteristics, and the latest research progress of secretion regulation network of T6SS in Salmonella, providing theoretical guidance for in-depth research on the pathogenic mechanism of Salmonella and the development of new antibacterial strategies.

Key words: Salmonella, T6SS, assembly, structural features, secretion regulatory networks

CLC Number:

S852.61

CHEN Songbiao, SHANG Ke, DU Fuxi, YU Zuhua, LI Jing, JIA Yanyan, LIAO Chengshui, ZHANG Chunjie, DING Ke, CHENG Xiangchao. Research Process of Assembly, Structural Features, and Secretion Regulatory Networks of Type VI Secretion System in Salmonella[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2252-2263.

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Research Process of Assembly, Structural Features, and Secretion Regulatory Networks of Type VI Secretion System in Salmonella

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