沙门菌脂多糖的结构修饰及其效应的研究进展

doi:10.11843/j.issn.0366-6964.2023.04.005

Abstract

Abstract: Salmonella is a zoonotic pathogen. It has a significant impact on human and animal health, and has caused significant economic losses to animal husbandry. Therefore, it is urgent to explore its pathogenic mechanism. Lipopolysaccharide, located in the outer membrane of Salmonella, is an important virulence factor. The modification of its structure can affect the immune escape ability, resistance and virulence of Salmonella. Based on this phenomenon, the mutant strains obtained by artificially modifying LPS can be used in the prevention and control of salmonellosis. In addition, low-toxicity derivative of LPS can be used to be vaccine adjuvants due to its useful immunostimulatory properties. Based on the above, the structural modification and its effects, biosynthesis and transport, and the application of Salmonella lipopolysaccharides are reviewed in this paper. Grasping the progress of this research is conducive to the in-depth study of the pathogenic mechanism of Salmonella,as well as the prevention and control of disease.

Key words: Salmonella, lipopolysaccharide, structural modification and effects, biosynthesis and transport, application

CLC Number:

S852.61

TIAN Yanhong, YU Jiangxu, JIAO Yuzhou, GAO Dongyang, CAI Xuwang. Research Progress on Structural Modification and Its Effects of Salmonella Lipopolysaccharides[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1392-1402.

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Research Progress on Structural Modification and Its Effects of Salmonella Lipopolysaccharides

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