内源性逆转录病毒的转录表达与宿主功能关系的研究进展

doi:10.11843/j.issn.0366-6964.2021.08.004

Abstract

Abstract: Endogenous retroviruses (ERVs) are the remains of ancient retroviruses that were infected and integrated into the host genome millions of years ago and inherited through Mendelian law. ERVs have important biological functions and play important roles influencing host phenotype, productivity, embryonic development and immune regulation. In this article, the genomic structure, activity regulation of ERVs by epigenetic modification and integration locus was reviewed. The relation between host embryonic development, immune regulation and ERVs was also discussed. It was expected to provide reference for further exploring the function of endogenous retrovirus in the genome and its influence and evolution in the host.

Key words: endogenous retrovirus, transcriptional regulation, integration locus, immune

CLC Number:

S852.659.3

BAI Shaochuan, ZHANG Lechao, GE Linhan, GUO Yanli, WANG Dehe, LI Lanhui. Research Progress of Relation between Transcriptional Expression of Endogenous Retrovirus and Host Function[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2107-2114.

References 66

[1]	LEE J, MUN S, KIM D H, et al. Chicken (Gallus gallus) endogenous retrovirus generates genomic variations in the chicken genome[J]. Mobile DNA, 2017, 8(1):2.
[2]	ADELSON D L, RAISON J M, EDGAR R C. Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome[J]. Proc Natl Acad Sci U S A, 2009, 106(31):12855-12860.
[3]	DAVID J G. Endogenous retroviruses in the human genome sequence[J]. Genome Biol, 2001, 2(6):reviews1017.
[4]	Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome[J]. Nature, 2002, 420(6915):520-562.
[5]	UEDA M T, KRYUKOV K, MITSUHASHI S, et al. Comprehensive genomic analysis reveals dynamic evolution of endogenous retroviruses that code for retroviral-like protein domains[J]. Mob DNA, 2020, 11(1):29.
[6]	GIFFORD R, TRISTEM M. The evolution, distribution and diversity of endogenous retroviruses[J]. Virus Genes, 2003, 26(3):291-315.
[7]	RANNAMÄE E, SAARMA U, ÄRMPALU-IDVAND A, et al. Retroviral analysis reveals the ancient origin of Kihnu native sheep in Estonia:implications for breed conservation[J]. Sci Rep, 2020, 10(1):17340.
[8]	GIFFORD W D, PFAFF S L, MACFARLAN T S. Transposable elements as genetic regulatory substrates in early development[J]. Trends Cell Biol, 2013, 23(5):218-226.
[9]	FUKUDA K, SHINKAI Y. SETDB1-mediated silencing of retroelements[J]. Viruses, 2020, 12(6):596.
[10]	CARPENTER M A, LI M, RATHORE A, et al. Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A[J]. J Biol Chem, 2012, 287(41):34801-34808.
[11]	HU X M, ZHU W Q, CHEN S H, et al. Expression patterns of endogenous avian retrovirus ALVE1 and its response to infection with exogenous avian tumour viruses[J]. Arch Virol, 2017, 162(1):89-101.
[12]	KUSE K, ITO J, MIYAKE A, et al. Existence of two distinct infectious endogenous retroviruses in domestic cats and their different strategies for adaptation to transcriptional regulation[J]. J Virol, 2016, 90(20):9029-9045.
[13]	CHUNG H C, NGUYEN V G, MOON H J, et al. Regulation of porcine endogenous retrovirus by dual LTR1+2(Long Terminal Region) miRNA in primary porcine kidney cells[J]. J Vet Sci, 2019, 20(5):e50.
[14]	GEIS F K, GOFF S P. Silencing and transcriptional regulation of endogenous retroviruses:an overview[J]. Viruses, 2020, 12(8):884.
[15]	OLSON E D, MUSIER-FORSYTH K. Retroviral Gag protein-RNA interactions:Implications for specific genomic RNA packaging and virion assembly[J]. Semin Cell Dev Biol, 2019, 86:129-139.
[16]	SU Q, LI Y, CUI Z Z, et al. The emerging novel avian leukosis virus with mutations in the pol gene shows competitive replication advantages both in vivo and in vitro[J]. Emerg Microbes Infect, 2018, 7(1):117.
[17]	BERTOZZI T M, ELMER J L, MACFARLAN T S, et al. KRAB zinc finger protein diversification drives mammalian interindividual methylation variability[J]. Proc Natl Acad Sci U S A, 2020, 117(3):31290-31300.
[18]	TSUSAKA T, FUKUDA K, SHIMURA C, et al. The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex[J]. Epigenetics Chromatin, 2020, 13(1):52.
[19]	ELMER J L, FERGUSON-SMITH A C. Strain-specific epigenetic regulation of endogenous retroviruses:the role of trans-acting modifiers[J]. Viruses, 2020, 12(8):810.
[20]	MASON A S, LUND A R, HOCKING P M, et al. Identification and characterisation of endogenous Avian Leukosis Virus subgroup E (ALVE) insertions in chicken whole genome sequencing data[J]. Mob DNA, 2020, 11(1):22.
[21]	MASON A S, MIEDZINSKA K, KEBEDE A, et al. Diversity of endogenous avian leukosis virus subgroup E (ALVE) insertions in indigenous chickens[J]. Genet Sel Evol, 2020, 52(1):29.
[22]	ROWE H M, TRONO D. Dynamic control of endogenous retroviruses during development[J]. Virology, 2011, 411(2):273-287.
[23]	WANG Z P, QU L J, YAO J F, et al. An EAV-HP insertion in 5' flanking region of SLCO1B3 causes blue eggshell in the chicken[J]. PLoS Genet, 2013, 9(1):e1003183.
[24]	CHANG C M, FURET J P, COVILLE J L, et al. Quantitative effects of an intronic retroviral insertion on the transcription of the tyrosinase gene in recessive white chickens[J]. Anim Genet, 2007, 38(2):162-167.
[25]	CHANG C M, COVILLE J L, COQUERELLE G, et al. Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens[J]. BMC Genomics, 2006, 7(1):19.
[26]	MALFAVON-BORJA R, FESCHOTTE C. Fighting fire with fire:endogenous retrovirus envelopes as restriction factors[J]. J Virol, 2015, 89(8):4047-4050.
[27]	LUGANINI A, GRIBAUDO G. Retroviruses of the human virobiota:the recycling of viral genes and the resulting advantages for human hosts during evolution[J]. Front Microbiol, 2020, 11:1140.
[28]	MEYER T J, ROSENKRANTZ J L, CARBONE L, et al. Endogenous retroviruses:with us and against us[J]. Front Chem, 2017, 5:23.
[29]	GROW E J, FLYNN R A, CHAVEZ S L, et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells[J]. Nature, 2015, 522(7555):221-225.
[30]	LU X Y, SACHS F, RAMSAY L A, et al. The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity[J]. Nat Struct Mol Biol, 2014, 21(4):423-425.
[31]	WRAGG D, MWACHARO J M, ALCALDE J A, et al. Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl[J]. PLoS One, 2013, 8(8):e71393.
[32]	LI Z J, REN T H, LI W Y, et al. SLCO1B3 association between the methylation statuses at CpG sites in the promoter region of the RNA expression and color change in blue eggshells in Lushi chickens[J]. Front Genet, 2019, 10:161.
[33]	LI J Y, DAVIS B W, JERN P, et al. Characterization of the endogenous retrovirus insertion in CYP19A1 associated with henny feathering in chicken[J]. Mob DNA, 2019, 10:38.
[34]	ZHANG X L, WANG H, ZHANG L C, et al. Analysis of a genetic factors contributing to feathering phenotype in chickens[J]. Poult Sci, 2018, 97(10):3405-3413.
[35]	TANAVE A, IMAI Y, KOIDE T. Nested retrotransposition in the east Asian mouse genome causes the classical nonagouti mutation[J]. Commun Biol, 2019, 2(1):283.
[36]	MURPHY S C, EVANS J M, TSAI K L, et al. Length variations within the Merle retrotransposon of canine PMEL:correlating genotype with phenotype[J]. Mob DNA, 2018, 9(1):26.
[37]	DAVID V A, MENOTTI-RAYMOND M, WALLACE A C, et al. Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats[J]. G3(Bethesda), 2014, 4(10):1881-1891.
[38]	KHAZAEE E, FARZANEH N, MIRSHOKRAEI P, et al. Expression of endogenous retroviruses in pre-implantation stages of bovine embryo[J]. Reprod Domest Anim, 2018, 53(6):1405-1414.
[39]	GÖKE J, LU X Y, CHAN Y S, et al. Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells[J]. Cell Stem Cell, 2015, 16(2):135-141.
[40]	NGO M H, ARNAL M, SUMI R, et al. Tracking the fate of endogenous retrovirus segregation in wild and domestic cats[J]. J Virol, 2019, 93(24):e01324-19.
[41]	KASSIOTIS G, STOYE J P. Immune responses to endogenous retroelements:taking the bad with the good[J]. Nat Rev Immunol, 2016, 16(4):207-219.
[42]	TAI A K, LIN M, CHANG F, et al. Murine Vβ3+ and Vβ7+ T cell subsets are specific targets for the HERV-K18 Env superantigen[J]. J Immunol, 2006, 177(5):3178-3184.
[43]	FRANK J A, FESCHOTTE C. Co-option of endogenous viral sequences for host cell function[J]. Curr Opin Virol, 2017, 25:81-89.
[44]	BEYER U, MOLL-ROCEK J, MOLL U M, et al. Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes[J]. Proc Natl Acad Sci U S A, 2011, 108(9):3624-3629.
[45]	SAKASHITA A, MAEZAWA S, TAKAHASHI K, et al. Endogenous retroviruses drive species-specific germline transcriptomes in mammals[J]. Nat Struct Mol Biol, 2020, 27(10):967-977.
[46]	MICHAELA K, ALGHAMDI F, RACZ M, et al. The impact of p53 on the early stage replication of retrovirus[J]. Virol J, 2017, 14(1):151.
[47]	CHEN S H, HU X M, CUI I H, et al. An endogenous retroviral element exerts an antiviral innate immune function via the derived lncRNA lnc-ALVE1-AS1[J]. Antivir Res, 2019, 170:104571.
[48]	PARRISH N F, FUJINO K, SHIROMOTO Y, et al. piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals[J]. RNA, 2015, 21(10):1691-1703.
[49]	KELLEHER E S, BARBASH D A. Analysis of piRNA-mediated silencing of active TEs in Drosophila melanogaster suggests limits on the evolution of host genome defense[J]. Mol Biol Evol, 2013, 30(8):1816-1829.
[50]	SUN Y H, XIE L H, ZHUO X Y, et al. Domestic chickens activate a piRNA defense against avian leukosis virus[J]. eLife, 2017, 6:e24695.
[51]	CHIAPPINELLI K B, STRISSEL P L, DESRICHARD A, et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses[J]. Cell, 2015, 162(5):974-986.
[52]	HU X M, ZHU W Q, CHEN S H, et al. Expression of the env gene from the avian endogenous retrovirus ALVE and regulation by miR-155[J]. Arch Virol, 2016, 161(6):1623-1632.
[53]	BANNERT N, HOFMANN H, BLOCK A, et al. HERVs new role in cancer:from accused perpetrators to cheerful protectors[J]. Front Microbiol, 2018, 9:178.
[54]	DE CUBAS A A, DUNKER W, ZANINOVICH A, et al. DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer[J]. JCI Insight, 2020, 5(11):e137569.
[55]	MUSTELIN T, UKADIKE K C. How retroviruses and retrotransposons in our genome may contribute to autoimmunity in rheumatological conditions[J]. Front Immunol, 2020, 11:593891.
[56]	MONTESION M, WILLIAMS Z H, SUBRAMANIAN R P, et al. Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites[J]. Retrovirology, 2018, 15(1):57.
[57]	DOLCI M, FAVERO C, TOUMI W, et al. Human endogenous retroviruses long terminal repeat methylation, transcription, and protein expression in human colon cancer[J]. Front Oncol, 2020, 10:569015, doi:10.3389/fonc. 2020.569015.
[58]	SACCO M A, CROSETTI A. GGERV20, a recently integrated, segregating endogenous retrovirus in Gallus gallus[J]. J Gen Virol, 2020, 101(3):299-308.
[59]	KRÜGER L, STILLFRIED M, PRINZ C, et al. Copy number and prevalence of porcine endogenous retroviruses (PERVs) in German wild boars[J]. Viruses, 2020, 12(4):419.
[60]	VENUGOPAL K. Avian leukosis virus subgroup J:a rapidly evolving group of oncogenic retroviruses[J]. Res Vet Sci, 1999, 67(2):113-119.
[61]	MAYS J K, BLACK-PYRKOSZ A, MANSOUR T, et al. Endogenous avian leukosis virus in combination with serotype 2 marek's disease virus significantly boosted the incidence of lymphoid leukosis-like bursal lymphomas in susceptible chickens[J]. J Virol, 2019, 93(23):e00861-19.
[62]	GAVORA J S, KUHNLEIN U, CRITTENDEN L B, et al. Endogenous viral genes:association with reduced egg production rate and egg size in White Leghorns[J]. Poult Sci, 1991, 70(3):618-623.
[63]	KA S, KERJE S, BORNOLD L, et al. Proviral integrations and expression of endogenous avian leucosis virus during long term selection for high and low body weight in two chicken lines[J]. Retrovirology, 2009, 6(1):68.
[64]	CHEN W G, QU H, LI C Y, et al. Polymorphism of avian leukosis virus subgroup E loci showing selective footprints in chicken[J]. Biochem Genet, 2014, 52(11-12):524-537.
[65]	ISHIHARA S, DANG-NGUYEN T Q, KIKUCHI K, et al. Characteristic features of porcine endogenous retroviruses in Vietnamese native pigs[J]. Anim Sci J, 2020, 91(1):e13336.
[66]	CHIU E S, VANDEWOUDE S. Presence of endogenous viral elements negatively correlates with feline leukemia virus susceptibility in puma and domestic cat cells[J]. J Virol, 2020, 94(21):e01274-20.

Research Progress of Relation between Transcriptional Expression of Endogenous Retrovirus and Host Function

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 66

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	MA Rumeng, ZHAO Yuliang, MA Mingshuang, GUO Guihai, LIU Xinzi, LI Jiaxuan, CUI Wen, JIANG Yanping, SHAN Zhifu, ZHOU Han, WANG Li, QIAO Xinyuan, TANG Lijie, WANG Xiaona, LI Yijing. Comparative Study on the Immune Response Induced by the Different Porcine Receptor Bacteria with Expressing the Protective Antigen S1 of Porcine Epidemic Diarrhea Virus [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 2090-2099.
[2]	LI Pengfei, GAO Guiqin, ZHOU Guangqing, WU Jinyan, YAN Xinmin, CAO Xiaoan, HE Jijun, YUAN Ligang, SHANG Youjun. Establishment and Application of TaqMan Fluorescence Quantitative RT-PCR Detection Method for Enzootic Nasal Tumor Virus of Goats [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 2259-2266.
[3]	WU Shangjie, LUAN Yuanyuan, WANG Mingkun, ZHANG Hechun, YU Bo, MA Yuehui, JIANG Lin, HE Xiaohong. Advances of Disease-Resistant Breeding on Ovine Brucellosis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 882-893.
[4]	MU Xiangyu, XU Yunruo, HU Jingyi, ZHOU Xinyan, ZHU Yongwen. Advances in Research on the Nutritional Requirements of Branched-Chain Amino Acids in Poultry [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 31-38.
[5]	WANG Dongliang, REN Jing, HAO Qinqin, LI Pengfei. Identification and Transcriptional Regulation Analysis of Core Promoter of Bovine CART Gene [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3689-3699.
[6]	ZHENG Xianrui, ZHUO Mingxue, JI Jinli, JIANG Weihu, DENG Zaishuang, ZHANG Jicheng, TIAN Yali, DING Yueyun, ZHANG Xiaodong, YIN Zongjun. Characteristics of Serum Immune Indices and Intestinal Microbiota of Wannan Black Pigs at Different Growth Stages [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3770-3783.
[7]	ZHONG Hua, SONG Shanshan, SHAO Huanting, ZHAO Yu, KANG Jinwen, WU Yao, SU Renwei. Transcriptome Sequencing Analysis on Canine Pyometra Uterine Tissue [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3383-3392.
[8]	JIAO Guangming, LÜ Yingguang, SANG Jinfang, KOU Zhipeng, LIU Tao, WANG Yue, LU Xiangyu, PIAO Chenxi, MA Yajun, ZHANG Jiantao, WANG Hongbin. Effect of Adipose Mesenchymal Stem Cells in Combination with Methylprednisolone on Allogeneic Skin Grafts in Minipigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3533-3545.
[9]	GUO Yanli, LI Keqiang, BAI Shaochuan, WANG Tao, WANG Dehe, WANG Qi, LI Lanhui. The Structure, Activity Regulation of ALV-E and Its Effects on Host Function [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2683-2691.
[10]	CHEN Xin, QIN Tong. mRNA Vaccine and Its Research Prospect in Zoonotic Diseases [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2732-2742.
[11]	CHEN Fangfang, LI Zhonghua, ZHU Zhiwei, LI Jinchun, LIU Cuiyan. Recent Advances in Multifunctional Research of Invariant Chain [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1824-1833.
[12]	LONG Qinqin, WEI Min, WANG Yuting, WEN Ming, PANG Feng. The Battle between Orf Virus and Host: Immune Response and Viral Immune Evasion Mechanisms [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1845-1853.
[13]	CAO Xiuyun, LIU Jiwen, TANG Zhihui, ZHENG Ziyi, YAN Liping, SONG Suquan. Isolation, Identification and Pathogenicity Analysis of a Duck Adenovirus Type 3 [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2050-2061.
[14]	XUAN Ting, YANG Kaiyi, CAI Jinshuang, GENG Yan, LI Yufeng. Analysis of the Immune Characteristics of the Six Recombinant Proteins of Glaesserella parasuis in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2073-2082.
[15]	WANG Zi, WANG Nianxiang, TIAN Changming, ZHAO Fujie, LIU Lintao, MA Mengyao, JIA Xinhao, LIU Guoxing, ZHENG Lanlan. Using Mouse to Evaluate the Immune Effect of Bridged Diphenylalanine Dipeptide with Inactivated Porcine Deltacoronavirus [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1590-1597.