HA蛋白位点变异影响H7N9亚型流感病毒特性的研究进展

doi:10.11843/j.issn.0366-6964.2021.08.003

Abstract

Abstract: In the spring of 2013, human infections with H7N9 subtype avian influenza emerged in China, posing serious threats to both poultry farming and public health. Additionally, highly pathogenic H7N9 variants with insertional mutation at the cleavage site of hemagglutinin (HA) protein yet evolved during the fifth epidemic wave. As the most abundantly expressed glycoprotein on the surface of influenza A virus, HA protein plays crucial roles in the viral lifecycle such as mediating the linkage between virus and host cell surface receptors, promoting the fusion between viral envelope and cell membrane, and stimulating the production of neutralizing antibodies. In this review, we briefly summarized the structure and function of HA protein, and the research progress of functional amino acid variations effecting on H7N9 biological properties, in order to provide important reference for in-depth analysis of the role of HA protein in H7N9 infection and pathogenesis.

Key words: influenza virus, H7N9, HA protein, functional amino acid sites, infection and pathogenesis

CLC Number:

S852.659.5

YAN Yayao, GU Min, LIU Xiufan. Advance in the Influence of Amino Acid Variation in HA Protein on the Biological Properties of H7N9 Subtype Influenza Virus[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2093-2106.

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Advance in the Influence of Amino Acid Variation in HA Protein on the Biological Properties of H7N9 Subtype Influenza Virus

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