mRNA疫苗及其在动物传染病中的研究展望

doi:10.11843/j.issn.0366-6964.2023.07.007

Abstract

Abstract: Nucleic acid vaccines based on messenger RNA (mRNA) are a new technology that has emerged in recent years. Compared with traditional vaccines, mRNA vaccines are characterized by strong immunogenicity, good safety, fast development cycle and easy large-scale production. In the past few years, kinds of mRNA vaccines for rabies and influenza and other applications, have entered clinical trials and shown good application prospects. The recent successful application of mRNA vaccines against COVID-19 further validates this platform. It also opens the floodgates to the application of mRNA vaccines for infectious disease prevention, particularly in veterinary medicine. In this paper, mRNA vaccine research, functional structures, delivery systems, the mechanism of action, and clinical applications, are reviewed in detail to provide references for research and development of mRNA vaccines in the field of animal disease prevention and control.

Key words: mRNA vaccine, delivery system, immune response, infectious diseases, zoonotic diseases

CLC Number:

S852.4

CHEN Xin, QIN Tong. mRNA Vaccine and Its Research Prospect in Zoonotic Diseases[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2732-2742.

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mRNA Vaccine and Its Research Prospect in Zoonotic Diseases

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