恒定链的多功能研究新进展

doi:10.11843/j.issn.0366-6964.2023.05.006

Abstract

Abstract: Invariant chain (Ii) is an important immune molecule. It is found that Ii is not only a MHCII chaperone, but also has multiple functions. In this paper, the basic structure, main functions, intracellular assembly and transport of Ii and the applications of Ii as a carrier are summarized. Secondly, it reviews the new progress of Ii research in recent years:the functional domain of interaction between Ii and MHC molecular and their intracellular localization characteristic, the function and pathway of regulating immune cells such as T and B, Ii and macrophage migration inhibitory factor to initiate signaling pathways and corresponding domains of inflammatory response; Various enzymes and bioactive factors associated with Ii and their action characteristics, diseases associated with Ii; Vaccine vector based on Ii structure and its mechanism of enhancing immunity; And the research results on livestock, poultry and fish. Finally, the development trend of Ii in the theoretical research and practical application in the field of animal husbandry and veterinary is prospected. This review provides scientific knowledge and the latest progress in understanding the multifunctional role and mechanism of Ii in animal immunity from the macro and micro aspects, and provides useful reference for promoting related research.

Key words: invariant chain, multi-function, immune regulation, vaccine carrier

CLC Number:

S852.4

CHEN Fangfang, LI Zhonghua, ZHU Zhiwei, LI Jinchun, LIU Cuiyan. Recent Advances in Multifunctional Research of Invariant Chain[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1824-1833.

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Recent Advances in Multifunctional Research of Invariant Chain

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