羊口疮病毒与宿主的博弈:免疫应答与病毒免疫逃逸机制

doi:10.11843/j.issn.0366-6964.2023.05.008

Abstract

Abstract: Contagious ecthyma, commonly known as orf, is a highly contagious and epitheliotropic zoonotic infectious disease caused by orf virus (ORFV), blocking the development of animal husbandry and threatening human health. Although ORFV infection can induce strong immune and inflammatory response, the host can be repeatedly infected. This is mainly because ORFV has developed and evolved multiple immune evasion mechanisms during the long-term interaction with the host. ORFV achieves immune evasion mainly by inhibiting interferon response, inhibiting NF-κB signaling pathway, inhibiting inflammatory response, regulating apoptosis, cell cycle, autophagy and vascular proliferation. The immune evasion of ORFV is mainly due to the multiple immunomodulatory proteins encoded by the virus. In this article, the latest research progress on host immune response against ORFV infection and the immune evasion mechanisms of ORFV are summarized, which provides ideas for orf vaccine development and comprehensive prevention and control of the disease.

Key words: orf, orf virus, immune response, immune evasion mechanisms, immunomodulatory protein

CLC Number:

S852.659.1

LONG Qinqin, WEI Min, WANG Yuting, WEN Ming, PANG Feng. The Battle between Orf Virus and Host: Immune Response and Viral Immune Evasion Mechanisms[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1845-1853.

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The Battle between Orf Virus and Host: Immune Response and Viral Immune Evasion Mechanisms

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