痛风雏鹅肾组织损伤的RNA-seq分析

doi:10.11843/j.issn.0366-6964.2020.03.024

Abstract

Abstract: We used RNA-seq to measure the transcription differences in renal tissues between gout and healthy goslings. Five goslings with typical visceral gout characteristics were selected as "gout group", while six healthy goslings were selected as the "control group". As a result, the transcription expressions of gout goslings in renal tissues were significantly different from that of healthy goslings. A total of 1 749 differential expression genes were found. Among these, 501 genes were up-regulated and 1 248 genes were down-regulated in the gout group. The GO and KEGG search revealed the differential expression genes mainly enriched in chemokine activity, T cell receptor binding, antigen binding and immune response, and participate in processes of cytokine-cytokine receptor interaction, intestinal immune network for IgA production, cell adhesion and so on.

Key words: gosling gout, renal injury, RNA-seq, immune response, inflammation damage

CLC Number:

S856.5

SHAO Chunrong, HUANG Yuanpi, HUANG Yunmao, YING Shijia, XI Yumeng, SHI Zhendan. RNA-seq Analysis on the Renal Tissue Injury in the Development of Goslings Gout[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 639-643.

References 14

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RNA-seq Analysis on the Renal Tissue Injury in the Development of Goslings Gout

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