非洲猪瘟病毒免疫逃逸分子机制研究进展

doi:10.11843/j.issn.0366-6964.2022.07.005

Abstract

Abstract: African swine fever virus (ASFV) infection causes an acute, intense, and highly contagious disease known as African swine fever (ASF). ASF outbreaks cause significant economic losses since there is no safe and effective vaccine has been developed. During the long-term interaction with the host, ASFV evolves various routes, such as inhibition of interferon and inflammation responses, regulation of apoptosis, autophagy and cellular immunity, to escape host immune surveillance to promote its replication, but the specific mechanism is still not completely clear. The complex immune escape mechanisms of ASFV may be the key factors that impede the development of effective ASF vaccine. Bioinformatics method can be used to analyze the genome and proteome of ASFV to Screen the key genes for immune regulation and protective antigen epitopes of the virus, which will be helpful for the study of molecular mechanism of ASFV immune escape and ASF vaccine development. In this review, research progresses on ASFV infection induced immune responses and the potential immune escape mechanisms of ASFV are summarized, which provides ideas for ASF vaccine development and comprehensive prevention and control of the disease.

Key words: African swine fever, African swine fever virus, immune response, immune escape, vaccine development

CLC Number:

S852.659.1

ZHAO Xuyang, JIN Jiaxin, LU Wenlong, ZHANG Shuai, HUANG Li, ZHANG Gaiping, SUN Aijun, ZHUANG Guoqing. Advances in the Molecular Mechanism of Immune Escape of African Swine Fever Virus[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2074-2082.

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Advances in the Molecular Mechanism of Immune Escape of African Swine Fever Virus

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