弓形虫病治疗:从传统药物到纳米药物

doi:10.11843/j.issn.0366-6964.2023.05.007

Abstract

Abstract: Toxoplasma gondii is a worldwide obligate intracellular protozoa that infects almost all warm-blooded animals and causes zoonotic toxoplasmosis. Individuals with normal immune function are often infected with Toxoplasma gondii without obvious clinical symptoms and show recessive infection, but pregnant women and individuals with immune deficiency can lead to serious consequences and need effective treatment. Toxoplasmosis is a common cause of abortion in sheep and goats worldwide. And it has a serious impact on human health and livestock production. Therefore, the control of human and animal toxoplasmosis is very important for public health and the economic development of animal husbandry. Previous drugs used to treat toxoplasmosis have been limited in their effectiveness due to side effects and/or disease staging. How-ever, nanoparticles can effectively overcome the limitations of traditional drugs. This article reviews the new progress of nanotechnology in the treatment of toxoplasmosis, in order to provide new ideas for the research of anti-toxoplasmosis drugs.

Key words: Toxoplasma gondii, traditional drugs, nano drug delivery system, solid lipidnanoparticles, polymer nanoparticles

CLC Number:

S853.32

SUN Xiaojing, ZHANG Lei, TIAN Tian, MA Xi, YAO Jia, WANG Yang. Unravelling Toxoplasma Treatment: Conventional Drugs toward Nanomedicine[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1834-1844.

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Unravelling Toxoplasma Treatment: Conventional Drugs toward Nanomedicine

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