畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (8): 3621-3630.doi: 10.11843/j.issn.0366-6964.2025.08.006

• 综述 • 上一篇    下一篇

纳米技术与CRISPR基因诊断技术在畜禽寄生虫病精准诊断中的应用

毛倩倩1,2(), 张岩1,2,*(), 周祥莹2, 单翠燕2, 郭超群2, 路庭欢2, 王丽2   

  1. 1. 青岛蔚蓝生物股份有限公司,青岛 266109
    2. 青岛康地恩动物药业有限公司,青岛 266109
  • 收稿日期:2024-12-31 出版日期:2025-08-23 发布日期:2025-08-28
  • 通讯作者: 张岩 E-mail:772074848@qq.com;zhangyan@vlandgroup.com
  • 作者简介:毛倩倩(1988-),女,山东青岛人,硕士,主要从事动物营养和兽药制剂研究,E-mail: 772074848@qq.com
  • 基金资助:
    泰山产业领军人才工程项目

Application of Nanotechnology and CRISPR Gene Diagnostics in Precision Detection of Livestock Parasitic Diseases

MAO Qianqian1,2(), ZHANG Yan1,2,*(), ZHOU Xiangying2, SHAN Cuiyan2, GUO Chaoqun2, LU Tinghuan2, WANG Li2   

  1. 1. Qingdao Vland Biotechnology Co., Ltd., Qingdao 266109, China
    2. Qingdao Kangdian Animal Pharmaceutical Co., Ltd., Qingdao 266109, China
  • Received:2024-12-31 Online:2025-08-23 Published:2025-08-28
  • Contact: ZHANG Yan E-mail:772074848@qq.com;zhangyan@vlandgroup.com

摘要:

畜禽寄生虫病是全球范围内对农业和公共卫生构成重大威胁的问题之一。这些疾病不仅导致家畜生产性能下降,还可能通过食物链传播给人类,引发严重的公共卫生问题。因此,畜禽寄生虫病的精准诊断显得尤为重要,能够及时识别和控制疾病,减少经济损失,并保护人类健康。然而,传统的诊断方法往往存在灵敏度和特异性不足的问题,限制了其在早期诊断和疾病监测中的应用。近年来,纳米技术和CRISPR基因编辑技术的发展为畜禽寄生虫病的精准诊断提供了新的工具和方法。纳米技术,特别是纳米材料的高比表面积和独特的光学、电学性质,使其在生物传感和分子诊断中展现出巨大潜力。CRISPR基因诊断技术以其精确性和高效性,已经成为基因功能研究和疾病诊断的重要工具。将这两种技术结合起来,可以开发出更加灵敏、特异、快速的诊断方法,以应对畜禽寄生虫病的挑战。本综述将探讨纳米技术和CRISPR基因诊断技术在畜禽寄生虫病精准诊断中的应用,通过深入研究纳米技术和CRISPR基因诊断技术的应用前景,为畜禽寄生虫病的早期诊断、疫苗研发以及有效防治策略提供强有力的支持,为保障动物健康和农业生产力的提升贡献新的科学力量。

关键词: 寄生虫病, 精准诊断, 纳米技术, CRISPR/Cas

Abstract:

Parasitic diseases in livestock and poultry are one of the major threats to agriculture and public health worldwide. These diseases not only lead to reduced productivity in animals but can also be transmitted to humans through the food chain, posing serious public health risks. Therefore, accurate diagnosis of parasitic infections in livestock and poultry is of paramount importance, as it enables timely identification and control of diseases, minimizes economic losses, and protects human health. However, traditional diagnostic methods often suffer from limitations in sensitivity and specificity, restricting their application in early diagnosis and disease surveillance. In recent years, advances in nanotechnology and CRISPR gene-editing technology have provided new tools and approaches for the precise diagnosis of parasitic diseases in animals. Nanotechnology, particularly the use of nanomaterials with high surface area and unique optical and electrical properties, has shown great potential in biosensing and molecular diagnostics. CRISPR-based diagnostic technology, known for its accuracy and efficiency, has emerged as a powerful tool in gene function research and disease detection. The integration of these two technologies can lead to the development of more sensitive, specific, and rapid diagnostic methods to deal with the challenges posed by parasitic infections in livestock and poultry. This review will explore the application of nanotechnology and CRISPR-based diagnostic techniques in the accurate diagnosis of animal parasitic diseases. By investigating their potential and prospects, this work aims to support early diagnosis, vaccine development, and effective control strategies of livestock parasitic diseases, ultimately contributing to animal health and improved agricultural productivity.

Key words: parasitic diseases, precise diagnosis, nanotechnology, CRISPR/Cas

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