沙门菌耐药基因水平转移机制及影响因素

doi:10.11843/j.issn.0366-6964.2026.01.010

Abstract

Abstract:

Salmonella is a common foodborne pathogen worldwide. With the promotion and use of antibiotics， more and more Salmonella produce or acquire antibiotic resistance genes （ARG） through vertical transmission and horizontal gene transfer （HGT）， causing widespread dissemination of antibiotic resistance. In the process of horizontal gene transfer， ARGs are mainly carried by mobile genetic elements （MGEs）， which are important mediators of HGT and can facilitate the spread of ARGs. Among them， MGEs mainly include plasmids， integrons and conjugative elements， transposons， insertion sequences， and phages， etc. MGE-associated transfer mechanisms， accessory gene compositions， and relationships between ARG dissemination and animal sources and geographic environments vary. The aim of this review is to outline the HGT mechanism of ARG in Salmonella， the different MGE-mediated HGT mechanisms and the influencing factors of HGT occurrence and development， which is of great significance for the in-depth investigation of the HGT mechanism of drug resistance in Salmonella.

Key words: Salmonella, horizontal gene transfer, antibiotic resistance gene, mobile genetic element

CLC Number:

S852.612

SUN Zeyuan, XIANG Lingxian, LI Lin, ZUO Runan. Mechanisms and Influencing Factors of Horizontal Transfer of Drug-resistant Genes in Salmonella[J]. Acta Veterinaria et Zootechnica Sinica, 2026, 57(1): 108-119.

Figures/Tables 2

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质粒 Plasmid	耐药性基因 ARGs	来源 Source	引用 Cite
IncA/C	strAB、sul2、tetAR、blaCMY-2、floR	动物（牛）	［20］
IncF	blaTEM-1、cmlA、aadA1、aadA2、sul3	人/动物（禽类）	［21］
IncF	strAB、tetA、tetC、tetD、aphA	人/动物（猪）	［22］
IncHI	tetB、tetAR、cat、sul2、blaTEM-1	人/动物（牛）	［23］
IncI	mcr-1（与多种质粒相关）	人	［24］
IncI	aadA、aac（3'）-IId、sul1、blaTEM-1、tetA	动物（火鸡）	［25］
IncN/IncX	qnr	人	［23］

耐药性基因/基因阵列 ARGs/ARG cassette	地区 Region	来源 Source	引用 Cite
aadA1	泰国	动物	［44］
aadA4a		动物（猪、禽类）
aadA5-orfD-dfrA17dfrA1-orfC		动物（猪、禽类）
blaPSE-1	马来西亚	人/动物（猪、禽类）
aadA2		人/动物
dfrA7		人/动物
dfrA12-orf-aadA2		人/动物
blaOXA-30-aadA1dfrA17-orf-aadA2dfrA17-aadA5	越南	人/动物

Mechanisms and Influencing Factors of Horizontal Transfer of Drug-resistant Genes in Salmonella

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