冠状病毒辅助蛋白功能研究进展

doi:10.11843/j.issn.0366-6964.2026.01.009

Abstract

Abstract:

The RNA genome of coronavirus contains multiple open reading frames， coding for structural proteins， non-structural proteins， as well as accessory proteins. The accessory proteins of coronavirus are species specific， and the amounts of accessory proteins differ between the species. Coronavirus accessory proteins are not necessary for viral replication， but some of them are involved in the host immune response， viral pathogenesis and virus virulence. Research on coronavirus accessory proteins will provide new potential targets for the development of therapeutic drugs and theoretical guidance for disease prevention and treatment. In this paper， the functions of several representative accessory proteins of coronaviruses are reviewed. It focuses on the relationship between accessory proteins and virus-host interactions， including the role of accessory proteins in promoting host cell apoptosis， host innate immune regulation， and pathogenicity in the host. This will help to investigate the infection and pathogenesis of coronavirus， and provide reference for developing new vaccines and antiviral drugs.

Key words: coronavirus, accessory protein, cell apoptosis, innate immunity, pathogenicity, vaccine

CLC Number:

S852.659.6

ZHAO Xiumei, ZHAO Haina, HUA Shu, CHENG Xu, CHEN Xiang, JIANG Yi. Research Progress on the Functions of Coronavirus Accessory Proteins[J]. Acta Veterinaria et Zootechnica Sinica, 2026, 57(1): 96-107.

Figures/Tables 5

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Table 1

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References 76

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种属 Genera	病毒 Virus	数量 Quantity	主要功能 Main functions
α-CoV	PEDV	1	调节宿主免疫反应与病毒毒力
	TGEV	3	调控宿主免疫反应、病毒毒力与组织嗜性
	FIPV	5	调控宿主免疫反应、炎症反应与病毒毒力
β-CoV	MHV	4	免疫抑制与病毒毒力
	MERS-CoV	5	免疫抑制、炎症反应、病毒毒力
	SARS- CoV	8	炎症反应、细胞凋亡、免疫抑制与病毒毒力
	SARS- CoV-2	9	炎症反应、细胞凋亡、免疫抑制与病毒毒力
γ-CoV	IBV	4	免疫抑制、发病机理与病毒毒力
δ-CoV	PDCoV	3	免疫抑制与病毒毒力

Research Progress on the Functions of Coronavirus Accessory Proteins

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