种养循环模式中黏菌素抗性基因mcr-1的归趋

doi:10.11843/j.issn.0366-6964.2025.10.008

Abstract

Abstract:

The resistance gene mcr-1, as a key genetic element mediating bacterial resistance to "last-resort" antibiotic colistin, has become a research hotspot since its discovery and poses a potential threat to public health. This paper aims to investigate the fate of colistin resistance gene mcr-1 in the planting-breeding cycling system. First, we summarize the resistance mechanisms, horizontal gene transfer, fitness costs, and compensatory evolution of mcr-1. Subsequently, we examine its occurrence, fate, and horizontal transmission characteristics in the planting-breeding cycling system, along with the key factors influencing its dissemination. Finally, we propose corresponding control measures, providing insights for high-quality development of circular agriculture and public health security.

Key words: crop-livestock integrated farming system, antibiotic resistance gene, mcr-1, fate, horizontal gene transfer, colistin

CLC Number:

S851

RAN Hongli, WEN Xin, XU Jiaojiao, CHEN Longhai, WU Yinbao. Fate of the Colistin Resistance Gene mcr-1 in Crop-Livestock Integrated Farming Systems[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(10): 4851-4862.

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样本来源 Sample sources	样本种类 Sample type	样本数量 Sample size	采样时间 Sampling time	地域分布 Geographical distribution	检出率或丰度 Detection rate or abundance
畜禽肠道 Livestock intestinal tract	鸡Chicken	275	2021年前	中国	5.8%^[37]
	鸭Duck	15	2024年	中国(广东)	100%^[38]
	猪Pig	325	2023年	中国(上海)	41.8%^[39]
	猪Pig	804	2012—2014年	中国(广东、广西、湖南、江西)	20.6%^[3]
	牛Cattle	118	2018年	中国(辽宁、陕西、贵州和湖南)	0.02 copies/16S rRNA gene copies^[36]
畜禽粪便 Livestock manure	鸡粪Chicken manure	202	2021年前	英国、德国、保加利亚、意大利、法国、西班牙、波兰、比利时、荷兰	7.4%^[37]
	鸭粪Duck manure	66	2022年	中国(青岛)	24.2%^[40]
	猪粪Pig manure	753	2019年	中国(武汉)	59.6%^[41]
	猪粪Pig manure	57	2021年	西班牙	7.0%^[42]
	牛粪Cattle manure	51	2019年	中国(江苏、浙江)	31.3%^[34]
	牛粪Cattle manure	152	2021年	西班牙	8.6%^[42]
畜禽污水 Livestock sewage	鸡场Chicken farm	53	2020年	中国东部	69.9%^[43]
	鸭场Duck farm	143	2017年	中国(广东)	22.4%^[44]
	猪场Pig farm	412	2016—2019年	中国(北京、河南、山东、四川和浙江)	>85%^[45]
	猪场Pig farm	65	2019年	中国(广东、福建、江苏、山东、河南和辽宁)	64.6%^[46]
	猪场Pig farm	/	2016年	中国(武汉)	5.0×10⁴ copies·L^-1^[47]

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Fate of the Colistin Resistance Gene mcr-1 in Crop-Livestock Integrated Farming Systems

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