外泌体对哺乳动物妊娠的调控作用

doi:10.11843/j.issn.0366-6964.2019.12.001

Abstract

Abstract: Exosomes widely exist in various body fluids, which including a variety of bioactive substances such as proteins, lipids, mRNA and miRNA. As one kind of "mediator", it transmits signals between cells, and it is associated with many kinds of physiological process. Recently, exosomes were found in uterine fluid, fallopian tube fluid and placenta, which showed that exosomes might take part in regulating gametogenesis, fertilization, placenta, embryo implantation and fetal development. Through the study of exosomes, many valuable results were obtained, which increased people's understanding for the process of mammalian pregnancy, and provided new ideas for the research of reproductive regulation mechanisms. Therefore, this review describes the development of exosomes, their role in mammalian pregnancy and the relationship between exosomes and pregnancy diseases, which will provide a reference for further revealing the regulatory role of exosomes in mammalian pregnancy.

Key words: exosomes, mammalian, pregnancy, placenta

CLC Number:

S814

ZHAO Le, YANG Haili, ZHANG Rong, YANG Yongheng, LI Jialu, ZHOU Heming, WANG Pan, ZHAO Yongju. The Regulation Role of Exosomes in Mammalian Pregnancy[J]. Acta Veterinaria et Zootechnica Sinica, 2019, 50(12): 2371-2378.

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The Regulation Role of Exosomes in Mammalian Pregnancy

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