circRNAs对哺乳动物肠道屏障功能的调控作用

doi:10.11843/j.issn.0366-6964.2023.11.001

Abstract

Abstract: circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) which are widely involved in various physiological activities. The intestine is an important digestive and immune organ in mammals, which provides nutrients and energy for the body through digestion, and the maintenance of the intestine barrier is closely related to animal health. It has recently been found that circRNAs play an important regulatory role in various physiological activities, and their regu-latory mechanisms in intestinal barrier function have been gradually revealed. Therefore, this paper describes the discovery, characteristics, classifications, functions and production mechanisms of circRNAs, focuses on reviewing the mechanisms of circRNAs in the mammalian intestinal barrier and looks forward to the application of circRNAs in animal husbandry, in order to provide some reference for the development of green and healthy farming.

Key words: circRNAs, mammalian, intestinal barrier, intestinal healthy

CLC Number:

S811.3

LUO Ju, MAO Jiani, XIA Yinzhao, YANG Zhenguo. Regulation of circRNAs on Mammalian Intestinal Barrier Function[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4439-4448.

References 64

[1]	TURNER J R.Intestinal mucosal barrier function in health and disease[J].Nat Rev Immunol,2009,9(11):799-809.
[2]	MOWAT A M.Anatomical basis of tolerance and immunity to intestinal antigens[J].Nat Rev Immunol,2003,3(4):331-341.
[3]	FARHADI A,BANAN A,FIELDS J,et al.Intestinal barrier:an interface between health and disease[J].J Gastroenterol Hepatol, 2003, 18(5):479-497.
[4]	ZENG B,CHEN T,LUO J Y,et al.Exploration of long non-coding RNAs and circular RNAs in porcine milk exosomes[J]. Front Genet,2020,11:652.
[5]	CHUNG H K,XIAO L,YU T X,et al.Sa1112 targeted deletion of circular RNA CDR1AS enhances Paneth cell function and intestial epithelial defense[J].Gastroenterology,2020,158(S6):S-279.
[6]	LI B,LI Y,LI L X,et al.Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis[J].Epigenomics,2021,13(17):1385-1401.
[7]	CHEN L L.The biogenesis and emerging roles of circular RNAs[J].Nat Rev Mol Cell Biol,2016,17(4):205-211.
[8]	SANGER H L,KLOTZ G,RIESNER D,et al.Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures[J].Proc Natl Acad Sci U S A,1976,73(11):3852-3856.
[9]	COCQUERELLE C,MASCREZ B,HÉTUIN D,et al.Mis-splicing yields circular RNA molecules[J].FASEB J,1993,7(1): 155-160.
[10]	HANSEN T B,JENSEN T I,CLAUSEN B H,et al.Natural RNA circles function as efficient microRNA sponges[J]. Nature, 2013,495(7441):384-388.
[11]	ZHANG Y,ZHANG X O,CHEN T,et al.Circular intronic long noncoding RNAs[J].Mol Cell,2013,51(6):792-806.
[12]	WESTHOLM J O,MIURA P,OLSON S,et al.Genome-wide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation[J].Cell Rep,2014,9(5):1966-1980.
[13]	JECK W R,SHARPLESS N E.Detecting and characterizing circular RNAs[J].Nat Biotechnol,2014,32(5):453-461.
[14]	DANAN M,SCHWARTZ S,EDELHEIT S,et al.Transcriptome-wide discovery of circular RNAs in Archaea[J].Nucleic Acids Res,2012,40(7):3131-3142.
[15]	WANG K,SINGH D,ZENG Z,et al.MapSplice:accurate mapping of RNA-seq reads for splice junction discovery[J].Nucleic Acids Res,2010,38(18):e178.
[16]	WANG Y J,XIAO H,ZHAO F L,et al.Decrypting the crosstalk of noncoding RNAs in the progression of IPF[J].Mol Biol Rep,2020,47(4):3169-3179.
[17]	PANDA A C,DE S,GRAMMATIKAKIS I,et al.High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs[J].Nucleic Acids Res,2017,45(12):e116.
[18]	HU Q,ZHOU T S.EIciRNA-mediated gene expression:tunability and bimodality[J].FEBS Lett,2018,592(20):3460-3471.
[19]	郭天雪.环状RNA hsa_circ_0000326对脑胶质瘤恶性生物学功能的调控作用及临床意义研究[D].兰州:兰州大学,2021.GUO T X.Study on the regulatory role of circular RNA hsa_circ_0000326 in malignant biological function and clinical significance of glioma[D].Lanzhou:Lanzhou University,2021.(in Chinese)
[20]	何天乐,董国忠,杨震国.circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响[J].畜牧兽医学报,2019, 50(10):1955-1962.HE T L,DONG G Z,YANG Z G.Regulation of circRNAs on mammalian placental nutrient transport and fetal development[J].Acta Veterinaria et Zootechnica Sinica,2019,50(10):1955-1962.(in Chinese)
[21]	LASDA E,PARKER R.Circular RNAs:diversity of form and function[J].RNA,2014,20(12):1829-1842.
[22]	PASQUINELLI A E,HUNTER S,BRACHT J.MicroRNAs:a developing story[J].Curr Opin Genet Dev,2005,15(2): 200-205.
[23]	EBERT M S,SHARP P A.Roles for microRNAs in conferring robustness to biological processes[J].Cell,2012, 149(3): 515-524.
[24]	LI Z,RUAN Y,ZHANG H Y,et al.Tumor-suppressive circular RNAs:Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets[J].Cancer Sci,2019,110(12):3630-3638.
[25]	SUN Z Q,CHEN C,SU Y F,et al.Regulatory mechanisms and clinical perspectives of circRNA in digestive system neoplasms[J].J Cancer,2019,10(13):2885-2891.
[26]	WANG Y,WANG Z F.Efficient backsplicing produces translatable circular mRNAs[J].RNA,2015,21(2):172-179.
[27]	BEILERLI A,GAREEV I,BEYLERLI O,et al.Circular RNAs as biomarkers and therapeutic targets in cancer[J].Semin Cancer Biol,2022,83:242-252.
[28]	FANG Z X,JIANG C J,LI S L.The potential regulatory roles of circular RNAs in tumor immunology and immunotherapy[J]. Front Immunol,2021,11:617583.
[29]	RAI A K,LEE B,HEBBARD C,et al.Decoding the complexity of circular RNAs in cardiovascular disease[J].Pharmacol Res,2021,171:105766.
[30]	LIN L H,ZHOU G S,CHEN P,et al.Which long noncoding RNAs and circular RNAs contribute to inflammatory bowel disease?[J].Cell Death Dis,2020,11(6):456.
[31]	MCGUCKIN M A,ERI R,SIMMS L A,et al.Intestinal barrier dysfunction in inflammatory bowel diseases[J].Inflamm Bowel Dis,2009,15(1):100-113.
[32]	TAKAHASHI Y,SATO S,KURASHIMA Y,et al.A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids[J].Stem Cell Rep,2018,10(1):314-328.
[33]	ZHU P P,ZHU X X,WU J Y,et al.IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3[J].Nat Immunol,2019,20(2):183-194.
[34]	GUO H,ZHANG J H,JIANG Z M,et al.Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability[J].EMBO J,2023,42(6):e112039.
[35]	LI Z X,WANG L X,ZHANG Y,et al.CircGLI3 inhibits oxidative stress by regulating the miR-339-5p/VEGFA axis in IPEC-J2 cells[J].Biomed Res Int,2021,2021:1086206.
[36]	方满新.非编码RNA在PCV2感染诱导猪肠上皮细胞炎症反应中的作用研究[D].长沙:湖南农业大学,2019.FANG M X.The roles of non-coding RNAs on PCV2-induced inflammation response in Porcine Epithelial intestinal cell[D].Changsha:Hunan Agricultural University,2019.(in Chinese)
[37]	ZHAO X M,MA X L,GUO J X,et al.Circular RNA circEZH2 suppresses transmissible gastroenteritis coronavirus-induced opening of mitochondrial permeability transition pore via targeting MiR-22 in IPEC-J2[J].Int J Biol Sci,2019, 15(10):2051-2064.
[38]	LIU S G,ZHANG D Z,LIU Y Q,et al.Circular RNA circ_0001105 protects the intestinal barrier of septic rats by inhibiting inflammation and oxidative damage and YAP1 expression[J].Gene,2020,755:144897.
[39]	YE L,SHI Y,ZHANG H F,et al.CircFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p[J].Inflamm Res,2023,72(3):509-529.
[40]	LIU J,LIU Y A,ZHANG L D,et al.Down-regulation of circDMNT3B is conducive to intestinal mucosal permeability dysfunction of rats with sepsis via sponging miR-20b-5p[J].J Cell Mol Med,2020,24(12):6731-6740.
[41]	ZHANG W W,LIAO Y,LOU J Q,et al.CircRNA_Maml2 promotes the proliferation and migration of intestinal epithelial cells after severe burns by regulating the miR-93-3p/FZD7/Wnt/β-catenin pathway[J].Burns Trauma,2022,10:tkac009.
[42]	DENG Y Q,XU X Q,MENG F Z,et al.PRP8-induced circMaml2 facilitates the healing of the intestinal mucosa via recruiting PTBP1 and regulating Sec62[J].Cells,2022,11(21):3460.
[43]	YANG Y W,MENG X,MENG Y Y,et al.CeRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway[J].Mol Ther Nucleic Acids,2021,25:173-185.
[44]	LI H L,WEI Y Y,LI X H,et al.Diosmetin has therapeutic efficacy in colitis regulating gut microbiota,inflammation,and oxidative stress via the circ-Sirt1/Sirt1 axis[J].Acta Pharmacol Sin,2022,43(4):919-932.
[45]	FRANCE M M,TURNER J R.The mucosal barrier at a glance[J].J Cell Sci,2017,130(2):307-314.
[46]	RANKIN C R,LOKHANDWALA Z A,HUANG R,et al.Linear and circular CDKN2B-AS1 expression is associated with inflammatory bowel disease and participates in intestinal barrier formation[J].Life Sci,2019,231:116571.
[47]	ZHAO J,LIN Z L,YING P,et al.CircSMAD4 promotes experimental colitis and impairs intestinal barrier functions by targeting Janus Kinase 2 through sponging miR-135a-5p[J].J Crohns Colitis,2023,17(4):593-613.
[48]	XIAO L,MA X X,LUO J,et al.Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing microRNA 29b function[J].Gastroenterology,2021,161(4):1303-1317. e3.
[49]	LI X X,XIAO L,CHUNG H K,et al.Interaction between HuR and circPABPN1 modulates autophagy in the intestinal epithelium by altering ATG16L1 translation[J].Mol Cell Biol,2020,40(6):e00492-19.
[50]	KWON M S,CHUNG H K,XIAO L,et al.MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1[J].Am J Physiol Cell Physiol,2021,320(6):C1042-C1054.
[51]	ZHU S B,TANG X L,GAO X F,et al.Hsa_circ_0013401 accelerates the growth and metastasis and prevents apoptosis and autophagy of neuroblastoma cells by sponging miR-195 to release PAK2[J].Oxid Med Cell Longev,2021,2021:9936154.
[52]	MO J S,ALAM K J,KIM H S,et al.MicroRNA 429 regulates mucin gene expression and secretion in murine model of colitis[J].J Crohns Colitis,2016,10(7):837-849.
[53]	LI B J,HE Y,WU W J,et al.Circular RNA profiling identifies novel circPPARA that promotes intramuscular fat deposition in pigs[J].J Agric Food Chem,2022,70(13):4123-4137.
[54]	VIVIER E,ARTIS D,COLONNA M,et al.Innate lymphoid cells:10 years on[J].Cell,2018,174(5):1054-1066.
[55]	LIU B Y,YE B Q,ZHU X X,et al.An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution[J].Nat Commun,2020,11(1):4076.
[56]	LIU B Y,LIU N,ZHU X X,et al.Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA[J].Cell Mol Immunol,2021,18(6):1412-1424.
[57]	LIU N,HE J C,FAN D D,et al.Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription[J].Nat Commun,2022,13(1):4711.
[58]	OUYANG W,WU M,WU A S,et al.Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88[J].Bioengineered,2022,13(5):12863-12875.
[59]	QU L,YI Z Y,SHEN Y,et al.Circular RNA vaccines against SARS-CoV-2 and emerging variants[J].Cell, 2022, 185(10): 1728-1744. e16.
[60]	LI H J,PENG K,YANG K,et al.Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies[J].Theranostics, 2022,12(14):6422-6436.
[61]	CHEN D L,QI L K,GUO Y R,et al.High sugar & fat diet influences the brain circRNA profiles in murine by regulating the gut-brain axis[J].SSRN Electronic Journal,2019. doi:10.2139/ssrn.3471987.
[62]	CHEN D L,QI L K,GUO Y R,et al.CircNF1-419 improves the gut microbiome structure and function in AD-like mice[J].Aging,2020,12(1):260-287.
[63]	ZHU Z X,HUANG J G,LI X,et al.Gut microbiota regulate tumor metastasis via circRNA/miRNA networks[J].Gut Microbes,2020,12(1):1788891.
[64]	GUO X Y,SHA Y Z,PU X N,et al.Coevolution of rumen epithelial circRNAs with their microbiota and metabolites in response to cold-season nutritional stress in Tibetan Sheep[J].Int J Mol Sci,2022,23(18):10488.

Regulation of circRNAs on Mammalian Intestinal Barrier Function

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