肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用

doi:10.11843/j.issn.0366-6964.2024.01.008

Abstract

Abstract: As messengers in the intercellular microenvironment, exosomes can mediate the transmission of signals between cells. Alveolar epithelial cells can regulate the body’s innate immune response in the form of exosomes. Under specific stimulation conditions, exosomes derived from alveolar epithelial cells target and regulate the gene expression pathway by delivering different effector active substances, and participate in the regulation of macrophage polarization, thereby controlling the pulmonary inflammatory response. This article reviews the latest research progress of alveolar epithelial cell-derived exosomes in regulating acute lung injury(ALI)by targeting macrophage polarization, provide reference for related research.

Key words: sepsis, acute lung injury, alveolar epithelial cells, alveolar macrophages, exosomes

CLC Number:

S856.3

WANG Xinxin, LIN Shumei, ZHAO Dongdong, WANG Xuesheng. Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 71-78.

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Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury

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