哺乳动物胎盘营养感应研究进展

doi:10.11843/j.issn.0366-6964.2022.05.001

Abstract

Abstract: Changes in maternal nutrition during gestation will affect the growth and development of the fetus. Placenta is an important interface for gas, nutrition and metabolite communication between maternal and fetus. The mammalian placental nutrition sensing system responds to the changes in maternal and fetal signals to ensure maternal health and promote the fetal growth and development. In view of its important role of the placental nutrition sensing system to mammalian reproduction, this article summarizes the effects of relevant signaling pathways including mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), hexosamine signaling pathway (Hexosamine), hlycogen synthase kinase 3 (GSK-3), insulin/insulin-like growth factor signaling pathway (IIS) and others on placental nutrition sensing and placental nutrient distribution to response nutrient changes in dam, subsequently to influence fetal development during pregnancy. All above are expected to provide theoretical basis for the breeding of mammals.

Key words: mammalian, placental nutrition sensing, placental nutrient distribution, signaling pathway

CLC Number:

S814.1

LIU Yueshuai, LIU Yan, CAO Xin, FENG Tao. Research Progress on Mammalian Placental Nutrition Sensing[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1321-1333.

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Research Progress on Mammalian Placental Nutrition Sensing

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