妊娠相关糖蛋白的生物学功能及其在畜牧生产中的研究进展

doi:10.11843/j.issn.0366-6964.2024.03.002

Abstract

Abstract: Pregnancy-associated glycoproteins (PAGs) belonging to the multigene family encoded by the aspartic protease gene, are a group of specific glycoproteins synthesized and secreted by placental trophoblast giant cells of artiodactyls, which can be detected in the maternal circulation after embryo attachment. It has the potential to serve multiple functions, including embryonic attachment, placental development, pregnancy maintenance, embryo survival, proteolytic activity, and immune regulation, which are most often used as biomarkers for early pregnancy diagnosis and assessment of embryo loss, as well as indicators of evaluation of fetal viability and monitoring placental health. In this paper, the origins and characteristics and biological functions of the PAGs family and its application in livestock production were reviewed, in order to provide reference for further research of PAGs biological functions and its rapid development in animal husbandry.

Key words: pregnancy-associated glycoproteins, placenta, origins and characteristics, biological function, livestock production

CLC Number:

S814

ZHONG Zhuxia, HU Xiuzhong, XIANG Min, YU Jie, LIU Chenhui, ZHAO Shenglan, WAN Pingmin, WANG Dingfa, ZHOU Yuan, CHENG Lei. Research Progress on Biological Function and Application of Pregnancy Associated Glycoproteins in Livestock Production[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 874-881.

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Research Progress on Biological Function and Application of Pregnancy Associated Glycoproteins in Livestock Production

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