铁死亡与炎症相关性研究进展

doi:10.11843/j.issn.0366-6964.2025.08.011

Abstract

Abstract:

Ferroptosis is a form of programmed cell death initiated by iron overload, lipid peroxidation and plasma membrane damage. It is intimately associated with physiological processes such as iron homeostasis and the redox system within the organism. Inflammation is an essential physiological mechanism within the organism, facilitating defensive responses to various injurious stimuli. Recent studies have demonstrated that ferroptosis is closely related to the inflammatory response process, and that these two processes are not merely unidirectional. The promotion of inflammation by ferroptosis is facilitated by the release of damage-associated molecular patterns (DAMPs), lipid oxidation products and chemokine pathways. Conversely, inflammatory pathways (JAK/STAT, NF-κB, inflammasome, cGAS-STING and MAPK) activated during inflammation and secreted cytokines (TNF-α, IL-1β and IL-10) can also trigger cellular ferroptosis. This article focuses on the molecular mechanisms of ferroptosis, the common inflammatory pathways activated during the inflammatory response and the secreted cytokines. The interactions between ferroptosis and inflammatory responses and the regulatory mechanisms are also analyzed in detail, which offers insights into the development of novel therapeutic strategies for inflammatory diseases.

Key words: ferroptosis, inflammation, lipid peroxidation, inflammatory pathways

CLC Number:

Q255

WEN Xue, XU Wanxue, FU Yitong, YANG Jie, FU Hongyu, FAN Ruifeng. Research Progress on the Relationship between Ferroptosis and Inflammation[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(8): 3666-3677.

Figures/Tables 2

References 97

1	YU H , GUO P , XIE X , et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases[J]. J Cell Mol Med, 2017, 21 (4): 648- 657. doi: 10.1111/jcmm.13008
2	BOLÍVAR B E , VOGEL T P , BOUCHIER-HAYES L . Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease[J]. FEBS J, 2019, 286 (14): 2628- 2644. doi: 10.1111/febs.14926
3	TSURUSAKI S , TSUCHIYA Y , KOUMURA T , et al. Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis[J]. Cell Death Dis, 2019, 10 (6): 449. doi: 10.1038/s41419-019-1678-y
4	陈敬宜, 于淼, 张金洋, 等. 铁死亡参与镉暴露鸡肝损伤的研究[J]. 畜牧兽医学报, 2023, 54 (2): 787- 802. doi: 10.11843/j.issn.0366-6964.2023.02.035
	CHEN J Y , YU M , ZHANG J Y , et al. Study on the involvement of ferroptosis in liver injury of cadmium-exposed chickens[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54 (2): 787- 802. doi: 10.11843/j.issn.0366-6964.2023.02.035
5	DIXON S J , LEMBERG K M , LAMPRECHT M R , et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149 (5): 1060- 1072. doi: 10.1016/j.cell.2012.03.042
6	LIANG D , MINIKES A M , JIANG X . Ferroptosis at the intersection of lipid metabolism and cellular signaling[J]. Mol Cell, 2022, 82 (12): 2215- 2227. doi: 10.1016/j.molcel.2022.03.022
7	TANG D , CHEN X , KANG R , et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31 (2): 107- 125. doi: 10.1038/s41422-020-00441-1
8	ROCHETTE L , DOGON G , RIGAL E , et al. Lipid peroxidation and iron metabolism: Two corner stones in the homeostasis control of ferroptosis[J]. Int J Mol Sci, 2022, 24 (1): 449. doi: 10.3390/ijms24010449
9	BOGDAN A R , MIYAZAWA M , HASHIMOTO K , et al. Regulators of iron homeostasis: New players in metabolism, cell death, and disease[J]. Trends Biochem Sci, 2016, 41 (3): 274- 286. doi: 10.1016/j.tibs.2015.11.012
10	LI D , LI Y . The interaction between ferroptosis and lipid metabolism in cancer[J]. Signal Transduct Target Ther, 2020, 5 (1): 108. doi: 10.1038/s41392-020-00216-5
11	JIANG L , WANG J , WANG K , et al. RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation[J]. Blood, 2021, 138 (8): 689- 705. doi: 10.1182/blood.2020008986
12	CHEN B Y , PATHAK J L , LIN H Y , et al. Inflammation triggers chondrocyte ferroptosis in TMJOA via HIF-1α/TFRC[J]. J Dent Res, 2024, 103 (7): 712- 722. doi: 10.1177/00220345241242389
13	ROEMHILD K , VON MALTZAHN F , WEISKIRCHEN R , et al. Iron metabolism: pathophysiology and pharmacology[J]. Trends Pharmacol Sci, 2021, 42 (8): 640- 656. doi: 10.1016/j.tips.2021.05.001
14	TANG M , CHEN Z , WU D , et al. Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases[J]. J Cell Physiol, 2018, 233 (12): 9179- 9190. doi: 10.1002/jcp.26954
15	GAO M , MONIAN P , PAN Q , et al. Ferroptosis is an autophagic cell death process[J]. Cell Res, 2016, 26 (9): 1021- 1032. doi: 10.1038/cr.2016.95
16	CHEN X , YU C , KANG R , et al. Iron metabolism in ferroptosis[J]. Front Cell Dev Biol, 2020, 8, 590226. doi: 10.3389/fcell.2020.590226
17	WANG K , CHEN X Z , WANG Y H , et al. Emerging roles of ferroptosis in cardiovascular diseases[J]. Cell Death Discov, 2022, 8 (1): 394. doi: 10.1038/s41420-022-01183-2
18	CHEN X , LI J , KANG R , et al. Ferroptosis: machinery and regulation[J]. Autophagy, 2021, 17 (9): 2054- 2081. doi: 10.1080/15548627.2020.1810918
19	INGOLD I , BERNDT C , SCHMITT S , et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis[J]. Cell, 2018, 172 (3): 409- 422. e21. doi: 10.1016/j.cell.2017.11.048
20	YANG Y , CHEN Y , FENG D , et al. Ficus hirta Vahl. ameliorates liver fibrosis by triggering hepatic stellate cell ferroptosis through GSH/GPX4 pathway[J]. Ethnopharmacol, 2024, 334, 118557. doi: 10.1016/j.jep.2024.118557
21	LIU D S , DUONG C P , HAUPT S , et al. Inhibiting the system x_C^-/glutathione axis selectively targets cancers with mutant-p53 accumulation[J]. Nat Commun, 2017, 8, 14844. doi: 10.1038/ncomms14844
22	JI X , QIAN J , RAHMAN S M J , et al. xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression[J]. Oncogene, 2018, 37 (36): 5007- 5019. doi: 10.1038/s41388-018-0307-z
23	SUN Y , CHEN P , ZHAI B , et al. The emerging role of ferroptosis in inflammation[J]. Biomed Pharmacother, 2020, 127, 110108. doi: 10.1016/j.biopha.2020.110108
24	DIXON S J , PATEL D N , WELSCH M , et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis[J]. Elife, 2014, 3, e02523. doi: 10.7554/eLife.02523
25	LONG Z , LUO Y , YU M , et al. Targeting ferroptosis: a new therapeutic opportunity for kidney diseases[J]. Front Immunol, 2024, 15, 1435139. doi: 10.3389/fimmu.2024.1435139
26	STOCKWELL B R , FRIEDMANN ANGELI J P , BAYIR H , et al. Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease[J]. Cell, 2017, 171 (2): 273- 285. doi: 10.1016/j.cell.2017.09.021
27	YAN B , AI Y , SUN Q , et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1[J]. Mol Cell, 2021, 81 (2): 355- 369. e10. doi: 10.1016/j.molcel.2020.11.024
28	DOLL S , FREITAS F P , SHAH R , et al. FSP1 is a glutathione-independent ferroptosis suppressor[J]. Nature, 2019, 575 (7784): 693- 698. doi: 10.1038/s41586-019-1707-0
29	KRAFT V A N , BEZJIAN C T , PFEIFFER S , et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling[J]. ACS Cent Sci, 2020, 6 (1): 41- 53. doi: 10.1021/acscentsci.9b01063
30	YANG W S , KIM K J , GASCHLER M M , et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis[J]. Proc Natl Acad Sci U S A, 2016, 113 (34): E4966- 75.
31	HASSANNIA B , VANDENABEELE P , VANDEN BERGHE T . Targeting ferroptosis to iron out cancer[J]. Cancer Cell, 2019, 35 (6): 830- 849. doi: 10.1016/j.ccell.2019.04.002
32	KAGAN V E , MAO G , QU F , et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nat Chem Biol, 2017, 13 (1): 81- 90. doi: 10.1038/nchembio.2238
33	LI N , WANG Y , WANG X , et al. Pathway network of pyroptosis and its potential inhibitors in acute kidney injury[J]. Pharmacol Res, 2022, 175, 106033. doi: 10.1016/j.phrs.2021.106033
34	ZHAO Y , DING W , CAI Y , et al. The m⁶ A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation[J]. Biochim Biophys Acta Mol Basis Dis, 2024, 1870 (7): 167354. doi: 10.1016/j.bbadis.2024.167354
35	BAI Y , MENG L , HAN L , et al. Lipid storage and lipophagy regulates ferroptosis[J]. Biochem Biophys Res Commun, 2019, 508 (4): 997- 1003. doi: 10.1016/j.bbrc.2018.12.039
36	ZOU Y , LI H , GRAHAM E T , et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis[J]. Nat Chem Biol, 2020, 16 (3): 302- 309. doi: 10.1038/s41589-020-0472-6
37	POPE L E , DIXON S J . Regulation of ferroptosis by lipid metabolism[J]. Trends Cell Biol, 2023, 33 (12): 1077- 1087. doi: 10.1016/j.tcb.2023.05.003
38	EVANS D R , GUY H I . Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway[J]. J Biol Chem, 2004, 279 (32): 33035- 33038. doi: 10.1074/jbc.R400007200
39	HANSEN M , LE NOURS J , JOHANSSON E , et al. Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain[J]. Protein Sci, 2004, 13 (4): 1031- 1042. doi: 10.1110/ps.03533004
40	DENG L , HE S , GUO N , et al. Molecular mechanisms of ferroptosis and relevance to inflammation[J]. Inflamm Res, 2023, 72 (2): 281- 299. doi: 10.1007/s00011-022-01672-1
41	COOKE J P . Inflammation and its role in regeneration and repair[J]. Circ Res, 2019, 124 (8): 1166- 1168. doi: 10.1161/CIRCRESAHA.118.314669
42	CHEN X , KANG R , KROEMER G , et al. Ferroptosis in infection, inflammation, and immunity[J]. J Exp Med, 2021, 218 (6): e20210518. doi: 10.1084/jem.20210518
43	CHEN Y , FANG Z M , YI X , et al. The interaction between ferroptosis and inflammatory signaling pathways[J]. Cell Death Dis, 2023, 14 (3): 205. doi: 10.1038/s41419-023-05716-0
44	HU X , LI J , FU M , et al. The JAK/STAT signaling pathway: from bench to clinic[J]. Signal Transduct Target Ther, 2021, 6 (1): 402. doi: 10.1038/s41392-021-00791-1
45	AWASTHI N , LIONGUE C , WARD A C . STAT proteins: A kaleidoscope of canonical and non-canonical functions in immunity and cancer[J]. J Hematol Oncol, 2021, 14 (1): 198. doi: 10.1186/s13045-021-01214-y
46	GUO W , ZHANG J , ZHANG X , et al. Environmental cadmium exposure perturbs systemic iron homeostasis via hemolysis and inflammation, leading to hepatic ferroptosis in common carp (Cyprinus carpio L.)[J]. Ecotoxicol Environ Saf, 2024, 275, 116246. doi: 10.1016/j.ecoenv.2024.116246
47	DONG X Q , CHU L K , CAO X , et al. Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis[J]. Redox Rep, 2023, 28 (1): 2152607. doi: 10.1080/13510002.2022.2152607
48	YU H , LIN L , ZHANG Z , et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study[J]. Signal Transduct Target Ther, 2020, 5 (1): 209. doi: 10.1038/s41392-020-00312-6
49	SUN S C . The non-canonical NF-κB pathway in immunity and inflammation[J]. Nat Rev Immunol, 2017, 17 (9): 545- 558. doi: 10.1038/nri.2017.52
50	YAN N , XU Z , QU C , et al. Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway[J]. Int Immunopharmacol, 2021, 98, 107844. doi: 10.1016/j.intimp.2021.107844
51	LI X , QIAN J , XU J , et al. NRF2 inhibits RSL3 induced ferroptosis in gastric cancer through regulation of AKR1B1[J]. Exp Cell Res, 2024, 442 (1): 114210. doi: 10.1016/j.yexcr.2024.114210
52	STOCKWELL B R . Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications[J]. Cell, 2022, 185 (14): 2401- 2421. doi: 10.1016/j.cell.2022.06.003
53	SCHNAPPAUF O , CHAE J J , KASTNER D L , et al. The pyrin inflammasome in health and disease[J]. Front Immunol, 2019, 10, 1745. doi: 10.3389/fimmu.2019.01745
54	HU Y , TANG J , XIE Y , et al. Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota[J]. J Ethnopharmacol, 2024, 328, 117956. doi: 10.1016/j.jep.2024.117956
55	KANG R , ZENG L , ZHU S , et al. Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis[J]. Cell Host Microbe, 2018, 24 (1): 97- 108. e4. doi: 10.1016/j.chom.2018.05.009
56	ZHANG D , WU C , BA D , et al. Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway[J]. Ecotoxicol Environ Saf, 2023, 253, 114655. doi: 10.1016/j.ecoenv.2023.114655
57	DECOUT A , KATZ J D , VENKATRAMAN S , et al. The cGAS-STING pathway as a therapeutic target in inflammatory diseases[J]. Nat Rev Immuno, 2021, 21 (9): 548- 569. doi: 10.1038/s41577-021-00524-z
58	CHENG Z , DAI T , HE X , et al. The interactions between cGAS-STING pathway and pathogens[J]. Signal Transduct Target Ther, 2020, 5 (1): 91. doi: 10.1038/s41392-020-0198-7
59	ARTHUR J S , LEY S C . Mitogen-activated protein kinases in innate immunity[J]. Nat Rev Immunol, 2013, 13 (9): 679- 692. doi: 10.1038/nri3495
60	ZHOU J R , ZHANG L D , WEI H F , et al. Neuropeptide Y induces secretion of high-mobility group box 1 protein in mouse macrophage via PKC/ERK dependent pathway[J]. J Neuroimmunol, 2013, 260 (1-2): 55- 59. doi: 10.1016/j.jneuroim.2013.04.005
61	MARTÍNEZ-LIMÓN A , JOAQUIN M , CABALLERO M , et al. The p38 Pathway: From biology to cancer therapy[J]. Int J Mol Sci, 2020, 21 (6): 1913. doi: 10.3390/ijms21061913
62	ZHANG Y , CONG Y , DU J , et al. Lif-deficiency promote systemic iron metabolism disorders and increases the susceptibility of osteoblasts to ferroptosis[J]. Bone, 2024, 189, 117266. doi: 10.1016/j.bone.2024.117266
63	LEE H N , NA H K , SURH Y J . Resolution of inflammation as a novel chemopreventive strategy[J]. Semin Immunopathol, 2013, 35 (2): 151- 161. doi: 10.1007/s00281-013-0363-y
64	MEDZHITOV R . Origin and physiological roles of inflammation[J]. Nature, 2008, 454 (7203): 428- 435. doi: 10.1038/nature07201
65	DURHAM G A , WILLIAMS J J L , NASIM M T , et al. Targeting SOCS proteins to control JAK-STAT signalling in disease[J]. Trends Pharmacol Sci, 2019, 40 (5): 298- 308. doi: 10.1016/j.tips.2019.03.001
66	WILTING J , BECKER J , BUTTLER K , et al. Lymphatics and inflammation[J]. Curr Med Chem, 2009, 16 (34): 4581- 4592. doi: 10.2174/092986709789760751
67	KENNEDY A D , DELEO F R . Neutrophil apoptosis and the resolution of infection[J]. Immunol Res, 2009, 43 (1-3): 25- 61. doi: 10.1007/s12026-008-8049-6
68	HUYNH M L , FADOK V A , HENSON P M . Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation[J]. J Clin Invest, 2002, 109 (1): 41- 50. doi: 10.1172/JCI0211638
69	WOJDASIEWICZ P , PONIATOWSKI Ł A , SZUKIEWICZ D . The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis[J]. Mediators Inflamm, 2014, 2014, 561459.
70	KIM E H , WONG S W , MARTINEZ J . Programmed necrosis and disease: We interrupt your regular programming to bring you necroinflammation[J]. Cell Death Differ, 2019, 26 (1): 25- 40. doi: 10.1038/s41418-018-0179-3
71	HOU H , QIN X , LI G , et al. Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis[J]. Sci Rep, 2024, 14 (1): 3335. doi: 10.1038/s41598-024-53976-3
72	JING X , CHEN Z , ZHANG M , et al. Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis[J]. Naunyn Schmiedebergs Arch Pharmacol, 2025, 398 (2): 1653- 1663. doi: 10.1007/s00210-024-03367-2
73	LIU L , WEN T , XIAO Y , et al. Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53/MAPK pathways[J]. J Ethnopharmacol, 2025, 336, 118726. doi: 10.1016/j.jep.2024.118726
74	HUANG J , CHEN X , LV Y . HMGB1 mediated inflammation and autophagy contribute to Endometriosis[J]. Front Endocrinol (Lausanne), 2021, 12, 616696. doi: 10.3389/fendo.2021.616696
75	XING D , XIA G , TANG X , et al. A Multifunctional nanocomposite hydrogel delivery system based on dual-loaded liposomes for scarless wound healing[J]. Adv Healthc Mater, 2024, 13 (28): e2401619. doi: 10.1002/adhm.202401619
76	LIU P , CHEN W , KANG Y , et al. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model[J]. Arch Biochem Biophys, 2023, 744, 109691. doi: 10.1016/j.abb.2023.109691
77	SU C , LIU Z , LIU L , et al. Protective effects of nodosin against lipopolysaccharide-induced acute kidney injury through regulation of oxidative stress, inflammation, and ferroptosis in rats[J]. Naunyn Schmiedebergs Arch Pharmacol, 2024, 397 (10): 8009- 8022. doi: 10.1007/s00210-024-03148-x
78	FENG Z , MENG F Y , HUO F , et al. Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STATS axis in M1 macrophages[J]. Redox Biol, 2024, 75, 103255. doi: 10.1016/j.redox.2024.103255
79	ZHANG Y , YE P , ZHU H , et al. Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway[J]. CNS Neurosci Ther, 2024, 30 (3): e14456. doi: 10.1111/cns.14456
80	WANG F , QI Y , GAO Y , et al. Syringic acid suppresses ferroptosis of skeletal muscle cells to alleviate lower limb ischemia/reperfusion injury in mice via the HMGB1 pathway[J]. Chem Biol Drug Des, 2023, 102 (6): 1387- 1398. doi: 10.1111/cbdd.14326
81	GUO L , ZHANG D , REN X , et al. SYVN1 attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury in rats by regulating the HMGB1/NRF2/HO-1 axis[J]. Int Immunopharmacol, 2023, 123, 110802. doi: 10.1016/j.intimp.2023.110802
82	UEDA N , TAKASAWA K . Impact of inflammation on ferritin, hepcidin and the management of iron deficiency anemia in chronic kidney disease[J]. Nutrients, 2018, 10 (9): 1173. doi: 10.3390/nu10091173
83	CHEN Y , YI X , HUO B , et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection[J]. Pharmacol Res, 2022, 177, 106122. doi: 10.1016/j.phrs.2022.106122
84	YANG L , WANG H , YANG X , et al. Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms[J]. Signal Transduct Target Ther, 2020, 5 (1): 138. doi: 10.1038/s41392-020-00253-0
85	LIU Y P , QIU Z Z , LI X H , et al. Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis[J]. World J Gastrointest Oncol, 2021, 13 (12): 2114- 2128. doi: 10.4251/wjgo.v13.i12.2114
86	ZHAO X , CHEN F . Propofol induces the ferroptosis of colorectal cancer cells by downregulating STAT3 expression[J]. Oncol Lett, 2021, 22 (5): 767. doi: 10.3892/ol.2021.13028
87	KONG R , WANG N , HAN W , et al. IFNγ-mediated repression of system xc^- drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells[J]. J Leukoc Biol, 2021, 110 (2): 301- 314. doi: 10.1002/JLB.3MA1220-815RRR
88	YAO F , DENG Y , ZHAO Y , et al. A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis[J]. Nat Commun, 2021, 12 (1): 7333. doi: 10.1038/s41467-021-27452-9
89	ZHONG X , ZHANG Z , SHEN H , et al. Hepatic NF-κB-Inducing Kinase and Inhibitor of NF-κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury[J]. Hepatol Commun, 2021, 5 (10): 1704- 1720. doi: 10.1002/hep4.1757
90	HU X , ZHANG H , ZHANG Q , et al. Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis[J]. J Neuroinflammation, 2022, 19 (1): 242. doi: 10.1186/s12974-022-02602-y
91	LI C , LIU J , HOU W , et al. STING1 Promotes ferroptosis through MFN1/2-dependent mitochondrial fusion[J]. Front Cell Dev Biol, 2021, 9, 698679. doi: 10.3389/fcell.2021.698679
92	SHI P , SONG C , QI H , et al. Up-regulation of IRF3 is required for docosahexaenoic acid suppressing ferroptosis of cardiac microvascular endothelial cells in cardiac hypertrophy rat[J]. J Nutr Biochem, 2022, 104, 108972. doi: 10.1016/j.jnutbio.2022.108972
93	GUPTA U , GHOSH S , WALLACE C T , et al. Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD[J]. Autophagy, 2023, 19 (1): 92- 111. doi: 10.1080/15548627.2022.2062887
94	MEIHE L , SHAN G , MINCHAO K , et al. The ferroptosis-NLRP1 inflammasome: The vicious cycle of an adverse pregnancy[J]. Front Cell Dev Biol, 2021, 9, 707959. doi: 10.3389/fcell.2021.707959
95	ZHENG Y , SONG J , QIAN Q , et al. Silver nanoparticles induce liver inflammation through ferroptosis in zebrafish[J]. Chemosphere, 2024, 362, 142673. doi: 10.1016/j.chemosphere.2024.142673
96	ZHOU D , SUN L , LI J , et al. Schisandrin B inhibits inflammation and ferroptosis in S.aureus-induced mastitis through regulating SIRT1/p53/SLC7A11 signaling pathway[J]. Int Immunopharmacol, 2024, 137, 112430. doi: 10.1016/j.intimp.2024.112430
97	ZHU K , ZHU X , SUN S , et al. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats[J]. Exp Neurol, 2021, 345, 113828. doi: 10.1016/j.expneurol.2021.113828

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Research Progress on the Relationship between Ferroptosis and Inflammation

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