长链酯酰辅酶A合成酶4介导铁死亡的发生机制

doi:10.11843/j.issn.0366-6964.2024.09.005

Abstract

Abstract:

Ferroptosis is an iron and lipid peroxidation-dependent mode of programmed death, and it is triggered when the accumulation of reactive oxygen species reaches a lethal level within the cell. Lipid reactive oxygen species produced by lipid peroxidation act on lipid molecules on cell membranes, resulting in lipid peroxidation and membrane damage, so lipid peroxidation is a prominent feature of ferroptosis. Long-chain acyl-CoA synthetase 4 (ACSL4) plays a crucial role in regulating lipid metabolism, primarily by esterifying polyunsaturated fatty acids and incorporating them into membrane phospholipids, thereby accelerating lipid peroxidation and driving ferroptosis. ACSL4-mediated ferroptosis is mainly regulated at transcriptional, post-transcriptional, and post-translational levels and plays an important role in lipid peroxidation-dependent diseases. The purpose of this study is to elucidate the mechanisms underlying ferroptosis, focusing on the upstream regulation of ACSL4 and consequently mechanism of ferroptosis, providing a theoretical basis for investigation into the mechanisms of ACSL4-mediated ferroptosis.

Key words: long-chain acyl-CoA synthetase 4, ferroptosis, lipid peroxidation, upstream regulation mechanism

CLC Number:

S852.3

Hongyu FU, Yue LI, Han CUI, Jiuzhi LI, Wanxue XU, Xi WANG, Ruifeng FAN. The Mechanism of Long-Chain acyl-CoA Synthetase 4-mediated Ferroptosis[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(9): 3792-3801.

Figures/Tables 3

References 70

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The Mechanism of Long-Chain acyl-CoA Synthetase 4-mediated Ferroptosis

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