T-2毒素对雄性动物生殖系统毒害机制的研究进展

doi:10.11843/j.issn.0366-6964.2025.05.005

Abstract

Abstract:

T-2 toxin is a mycotoxin widely found in grains and animal feed, posing a significant threat to human and animal health. The review aims to provide a comprehensive summary of the sources, physicochemical properties, and reproductive toxicity of T-2 toxin, with a particular focus on its mechanisms and effects on male reproductive systems. The review explores the toxicological pathways of T-2 toxin, including oxidative stress, mitochondrial damage, and cell apoptosis, and their impact on testicular function, sperm quality, and endocrine regulation of reproduction. Additionally, the review discusses the effects of T-2 toxin exposure on leydig cells, sertoli cells, and spermatogenesis, as well as examines the potential application of antioxidants and natural detoxifying agents in alleviating reproductive dysfunction induced by T-2 toxin. By analyzing the toxicity mechanisms of T-2 toxin, this review provides guidance for future research and aims to provide scientific evidence for developing effective prevention strategies and detoxification agents, thereby safeguarding livestock reproductive health and promoting sustainable development of the animal husbandry industry.

Key words: T-2 toxin, male animal reproduction, oxidative stress, inflammation, apoptosis

CLC Number:

S814.1

CHEN Yun, CHEN Liyuan, SONG Wenjing, ZHANG Xinke, XU Han, WU Jiayi, ZHAO Cuiyan, ZHANG Shouquan. Research Progress on the Mechanism of T-2 Toxin 's Impact on Male Animal Reproduction[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(5): 2038-2046.

Figures/Tables 3

References 68

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名称 Name	作用 Effect	文献 Reference
原花青素B2 Procyanidin B2	缓解各种毒素引起的氧化损伤	^{[53, 54]}
桦木酸 Betulinic acid	抗炎、抗氧化、抗病毒、抗癌、抗寄生虫和抗感染	^{[55, 56]}
单宁酸 Tannic acid	较强的抗氧化活性	^{[1, 57]}
L-精氨酸 L-arginine	抗氧化性，不仅能清除ROS，也能提高抗氧化酶活性	^{[32, 36]}
褪黑素 Melatonin	天然强效的抗氧化剂	^{[19, 58]}
叔丁基对苯二酚 Tert-butylhydroquinone	抗氧化、抗凋亡和抗炎特性	^[30]
绿茶粉 Green tea powders	解毒能力	^{[59, 60]}
槲皮素 Quercetin	抗氧化、抗炎、抗癌、镇痛、抗病毒、免疫调节	^[62-64]
α-生育酚 Alpha-tocopherol	抵抗T-2毒素诱导的毒性	^{[43, 64, 65]}
辅酶Q10 Coenzyme Q10	自由基清除剂	^[65]
左旋肉碱 L-carnitine	自由基清除剂	^[66]
硒 Selenium	抗氧化作用	^{[43, 67, 68]}

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Research Progress on the Mechanism of T-2 Toxin 's Impact on Male Animal Reproduction

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