非编码RNA在传染性法氏囊病病毒感染中的研究进展

doi:10.11843/j.issn.0366-6964.2024.04.014

Abstract

Abstract: Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). In recent years, with the emergence of IBDV novel variant strains, IBDV still threatens the poultry industry worldwide. It seems that the battle between host and IBDV will never end. Thus, it is urgent to develop a more comprehensive and effective strategy for the control of this disease. A better understanding of the mechanisms underlying virus-host interactions would be of help in the development of novel vaccines. Noncoding RNA (ncRNAs) are an abundant class of RNAs that do not encode proteins. NcRNAs include microRNA (miRNAs), long noncoding RNA (lncRNAs), circular RNA (circRNAs) and small nuclear RNA (snRNAs). Recently, many studies confirmed that noncoding RNA (ncRNAs) were widely involved in the interaction of IBDV and the host, and played a crucial regulatory role in IBDV infection. This review elaborated the role of miRNAs, lncRNAs, and circRNAs in IBDV infection, which will further provide theoretical guidance and new ideas for the development of novel IBDV vaccines or antiviral drugs.

Key words: infectious bursal disease virus, non-coding RNA, miRNA, lncRNA, circRNA

CLC Number:

S858.315.3

LIU Weiye, HUANG Xuewei. Research Progress of Non-coding RNA in Infectious Bursal Disease Virus Infection[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1488-1498.

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Research Progress of Non-coding RNA in Infectious Bursal Disease Virus Infection

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