miRNA介导应激幼畜肠道损伤的研究进展

doi:10.11843/j.issn.0366-6964.2023.03.003

Abstract

Abstract: With the rapid development of animal husbandry, intensive feeding and early weaning strategy comes into being. At the same time, all kinds of stress (such as heat stress, cold stress, weaning stress, transport stress, oxidative stress) increase, resulting in intestine injury of young farm animals whose immune system has not been fully established, which is life-threatening in serious cases. miRNA is a kind of endogenous non-coding single-stranded small RNA, which can regulate gene expression. As an important member of the gene family, miRNA was involved in almost all the signaling pathways in the body. miRNA could regulate the proliferation and differentiation of intestinal epithelial cells and mediate intestinal mucosal barrier injury. This review summarized the effect of stress on intestinal mucosal barrier function, the regulatory role and possible pathways of miRNA on intestinal mucosal barrier function of young farm animals. At the same time, the mode of miRNA participating in the action of exogenous additives was reviewed to provide a theoretical basis for nutrients targeted intervention to regulate the intestinal immune function of young farm animals, and was of great significance to improve the breeding of young farm animals.

Key words: stress, miRNA, intestinal mucosal barrier

CLC Number:

S813
S815.7

HAN Lulu, HAN Deping, ZHAO Qinan, DIAO Qiyu, CUI Kai. Research Progress of Intestinal Injury in Young Farm Animals under Stress Mediated by miRNA[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 877-888.

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Research Progress of Intestinal Injury in Young Farm Animals under Stress Mediated by miRNA

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