牛呼吸道合胞体病毒G和F蛋白的生物学功能

doi:10.11843/j.issn.0366-6964.2024.04.013

Abstract

Abstract: Bovine respiratory syncytial virus (BRSV) is one of the viral causes of bovine respiratory diseases worldwide, mainly causing severe lower respiratory tract infections in calves under 1 year of age. BRSV encodes a total of 9 structural proteins, among which attachment protein (G protein) and fusion protein (F protein) are the main envelope glycoproteins on the surface of BRSV, which participate in the process of viral adsorption and fusion of host cells. G and F proteins contain a variety of identifying epitopes that stimulate the body′s production of neutralizing antibody responses and are often the focus of vaccine development for Bovine respiratory syncytial disease (BRSD). Exploring the mechanism of G and F proteins in BRSV infection is of great significance for the analysis of viral pathogenesis and vaccine development. This article aims to review the structural functions of BRSV G and F proteins and the development of related vaccines, in order to provide reference for the development of BRSV vaccine and the prevention and control of BRSD.

Key words: bovine respiratory syncytial virus (BRSV), bovine respiratory syncytial disease (BRSD), attachment proteins (G proteins), fusion protein (F protein), vaccine

CLC Number:

S852.659.5

GUO Xuelian, LI Yongqin, LI Ruiqian, LI Hao, JIN Shuangyuan, WANG Xueyan, DU Jiawei, XU Lihua. Biological Functions of Bovine Respiratory Syncytial Virus G and F Proteins[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1478-1487.

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Biological Functions of Bovine Respiratory Syncytial Virus G and F Proteins

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