营养物质对动物内源性宿主防御肽表达的调节作用

doi:10.11843/j.issn.0366-6964.2020.08.001

Abstract

Abstract: Host defense peptide is a multifunctional peptide produced by animals. It not only has broad-spectrum antimicrobial function, but also can be used as an innate immune regulator to enhance the body immunity and prevent the invasion of pathogenic microorganisms. It plays an significant role in ensuring animal health. The expression of host defense peptide is regulated by various nutrients in the diet. Some researchers suggested that promoting the expression of host endogenous defense peptide by nutritional regulation was beneficial to the improvement of animal health and production performance, and was one of the possible strategies to achieve antibiotic-free and healthy breeding in the future. In this review, the regulation of endogenous defense peptide expression by various nutrients is discussed comprehensively, which will provide a new theoretical reference for evaluating the effects of nutrients on host immunity and animal health and production.

Key words: host defense peptide, endogenous nutrients, express regulation

CLC Number:

S852.4

CHEN Yonghong, LUO Fang, TAO Jinzhong, WANG Jing. Regulation of Nutrients on the Expression of Endogenous Host Defense Peptide in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(8): 1775-1783.

References 65

[1]	ZHU Y G,JOHNSON T A,SU J Q,et al.Diverse and abundant antibiotic resistance genes in Chinese swine farms[J].Proc Natl Acad Sci U S A,2013,110(9):3435-3440.
[2]	WU J M,MA N,JOHNSTON L J,et al.Dietary nutrients mediate intestinal host defense peptide expression[J].Adv Nutr,2020,11(1):92-102.
[3]	ZASLOFF M.Antimicrobial peptides of multicellular organisms[J].Nature,2002,415(6870):389-395.
[4]	GWYER FINDLAY E,CURRIE S M,DAVIDSON D J.Cationic host defence peptides:potential as antiviral therapeutics[J].BioDrugs,2013,27(5):479-493.
[5]	VAN DER WEERDEN N L,BLEACKLEY M R,ANDERSON M A.Properties and mechanisms of action of naturally occurring antifungal peptides[J].Cell Mol Life Sci,2013,70(19):3545-3570.
[6]	MANGONI M L,DERMOTT A M,ZASLOFF M.Antimicrobial peptides and wound healing:biological and therapeutic considerations[J].Exp Dermatol,2016,25(3):167-173.
[7]	张萌萌,姜宁,张爱忠,等.饲料添加剂影响内源性抗菌肽表达和免疫调节机制[J].动物营养学报,2019,31(1):90-96.ZHANG M M,JIANG N,ZHANG A Z,et al.Feed additives affect endogenous antimicrobial peptide expression and immunoregulatory mechanisms[J].Chinese Journal of Animal Nutrition,2019,31(1):90-96.(in Chinese)
[8]	王鑫,张萌萌,姜宁,等.宿主防御肽调节动物肠道屏障功能的研究进展[J].动物营养学报,2018,30(9):3410-3416.WANG X,ZHANG M M,JIANG N,et al.Research progress in regulation of animal intestinal barrier function by host defense peptides[J].Chinese Journal of Animal Nutrition,2018,30(9):3410-3416.(in Chinese)
[9]	汪以真.动物源抗菌肽的研究现状和展望[J].动物营养学报,2014,26(10):2934-2941.WANG Y Z.Antimicrobial peptides of animal origin:current situation and prospect[J].Chinese Journal of Animal Nutrition,2014,26(10):2934-2941.(in Chinese)
[10]	XIAO H,WU M M,TAN B E,et al.Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol:I.Growth performance,immune function,and antioxidation capacity[J].J Anim Sci,2013,91(10):4772-4780.
[11]	YOON J H,INGALE S L,KIM J S,et al.Effects of dietary supplementation with antimicrobial peptide-P5 on growth performance,apparent total tract digestibility,faecal and intestinal microflora and intestinal morphology of weanling pigs[J].J Sci Food Agric,2013,93(3):587-592.
[12]	MISHRA B,REILING S,ZARENA D,et al.Host defense antimicrobial peptides as antibiotics:design and application strategies[J].Curr Opin Chem Biol,2017,38:87-96.
[13]	CHOI S C,INGALE S L,KIM J S,et al.Effects of dietary supplementation with an antimicrobial peptide-P5 on growth performance,nutrient retention,excreta and intestinal microflora and intestinal morphology of broilers[J].Anim Feed Sci Technol,2013,185(1-2):78-84.
[14]	CHOI S C,INGALE S L,KIM J S,et al.An antimicrobial peptide-A3:effects on growth performance,nutrient retention,intestinal and faecal microflora and intestinal morphology of broilers[J].Br Poult Sci,2013,54(6):738-746.
[15]	WEN L F,HE J G.Dose-response effects of an antimicrobial peptide,a cecropin hybrid,on growth performance,nutrient utilisation,bacterial counts in the digesta and intestinal morphology in broilers[J].Br J Nutr,2012,108(10):1756-1763.
[16]	彭建,赵行行,吴兆颖,等.抗菌肽Cec4的结构改造及抗菌活性研究[J].生物技术,2019,29(4):330-335.PENG J,ZHAO X X,WU Z Y,et al.Structural modification and antibacterial related activity study of antimicrobial peptide Cec4[J].Biotechnology,2019,29(4):330-335.(in Chinese)
[17]	DONG N,MA Q Q,SHAN A S,et al.Novel design of short antimicrobial peptides derived from the bactericidal domain of avian β-defensin-4[J].Protein Pept Lett,2012,19(11):1212-1219.
[18]	黄佳明,姜宁,张爱忠.基因工程菌生产抗菌肽的研究进展[J].微生物学通报,2019,46(3):654-659.HUANG J M,JIANG N,ZHANG A Z.Progress in engineering bacteria producing antibacterial peptides[J].Microbiology China,2019,46(3):654-659.(in Chinese)
[19]	CHEN X,ZHU F M,CAO Y H,et al.Novel expression vector for secretion of cecropin AD in Bacillus subtilis with enhanced antimicrobial activity[J].Antimicrob Agents Chemother,2009,53(9):3683-3689.
[20]	PERRON G G,ZASLOFF M,BELL G.Experimental evolution of resistance to an antimicrobial peptide[J].Proc Roy Soc B:Biol Sci,2006,273(1583):251-256.
[21]	ONG Z Y,CHENG J C,HUANG Y,et al.Effect of stereochemistry,chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles[J].Biomaterials,2014,35(4):1315-1325.
[22]	ROBINSON K,MA X,LIU Y L,et al.Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics[J].Anim Nutr,2018,4(2):160-169.
[23]	BECKER T,LOCH G,BEYER M,et al.FOXO-dependent regulation of innate immune homeostasis[J].Nature,2010,463(7279):369-373.
[24]	LYU W,CURTIS A R,SUNKARA L T,et al.Transcriptional regulation of antimicrobial host defense peptides[J].Curr Protein Pept Sci,2015,16(7):672-679.
[25]	HANEY E F,STRAUS S K,HANCOCK R E W.Reassessing the host defense peptide landscape[J].Front Chem,2019,7:43.
[26]	SUNKARA L T,JIANG W Y,ZHANG G L.Modulation of antimicrobial host defense peptide gene expression by free fatty acids[J].PLoS One,2012,7(11):e49558.
[27]	陈金永.猪β-防御素基因表达特点及维生素A的调节作用[D].雅安:四川农业大学,2010.CHEN J Y.Porcine β-defensin gene expression and its regulation by vitamin A[D].Ya'an:Sichuan Agricultural University,2010.(in Chinese)
[28]	TIAN G,LIANG X F,CHEN D W,et al.Vitamin D3 supplementation alleviates rotavirus infection in pigs and IPEC-J2 cells via regulating the autophagy signaling pathway[J].J Steroid Biochem Mol Biol,2016,163:157-163.
[29]	ZHANG L,LU L,LI S M,et al.1,25-Dihydroxyvitamin-D3induces avian β-defensin gene expression in chickens[J].PLoS One,2016,11(5):e0154546.
[30]	KWEH M F,MERRIMAN K E,NELSON C D.Short communication:Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells[J].J Dairy Sci,2019,102(6):5706-5712.
[31]	WATTS K M,LAHIRI P,ARRAZURIA R,et al.Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis[J].Cell Tissue Res,2020,379(2):337-348.
[32]	SUNKARA L T,ACHANTA M,SCHREIBER N B,et al.Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression[J].PLoS One,2011,6(11):e27225.
[33]	ZENG X F,SUNKARA L T,JIANG W Y,et al.Induction of porcine host defense peptide gene expression by short-chain fatty acids and their analogs[J].PLoS One,2013,8(8):e72922.
[34]	XIONG H T,GUO B X,GAN Z S,et al.Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition[J].Sci Rep,2016,6:27070.
[35]	SUNKARA L T,ZENG X F,CURTIS A R,et al.Cyclic AMP synergizes with butyrate in promoting β-defensin 9 expression in chickens[J].Mol Immunol,2014,57(2):171-180.
[36]	洪智敏.乳酸杆菌对鸡小肠上皮细胞抗菌肽AvBD9基因表达的影响[D].南昌:江西农业大学,2011.HONG Z M.Effects of lactobacilli on the gene expression of antibacterial peptide AvBD9 in chicken intestinal epithelial cells[D].Nanchang:Jiangxi Agricultural University,2011.(in Chinese)
[37]	洪智敏,张和平,贾永杰,等.发酵乳酸杆菌F6对鸡小肠上皮细胞β-防御素-9基因表达的影响[J].中国兽医学报,2012,32(8):1142-1147.HONG Z M,ZHANG H P,JIA Y J,et al.Effect of probiotic Lactobacillus fermentum F6 on β-defensin-9 expression in epithelial cells of chicken small intestine[J].Chinese Journal of Veterinary Science,2012,32(8):1142-1147.(in Chinese)
[38]	WANG J,ZENG Y X,WANG S X,et al.Swine-derived probiotic Lactobacillus plantarum inhibits growth and adhesion of enterotoxigenic Escherichia coli and mediates host defense[J].Front Microbiol,2018,9:1364.
[39]	WANG J,ZHANG W,WANG S X,et al.Swine-derived probiotic Lactobacillus plantarum modulates porcine intestinal endogenous host defense peptide synthesis through TLR2/MAPK/AP-1 signaling pathway[J].Front Immunol,2019,10:2691.
[40]	LIU H B,HOU C L,WANG G,et al.Lactobacillus reuteri I5007 modulates intestinal host defense peptide expression in the model of IPEC-J2 cells and neonatal piglets[J].Nutrients,2017,9(6):559.
[41]	贾永杰.鼠李糖乳杆菌对鸡小肠上皮细胞β-防御素9基因表达的影响及其信号转导途径[D].南昌:江西农业大学,2012.JIA Y J.Effects of Lactobacillus rhamnosus on β-defensin 9 expression and its signal transduction pathway in chicken small intestinal epithelial cells[D].Nanchang:Jiangxi Agricultural University,2012.(in Chinese)
[42]	黎观红,洪智敏,贾永杰,等.鼠李糖乳酸杆菌LGA对鸡小肠上皮细胞β-防御素-9基因表达的影响[J].畜牧兽医学报,2012,43(4):634-641.LI G H,HONG Z M,JIA Y J,et al.Effect of Lactobacillus rhamnosus LGA on β-defensin 9 expression in cultured chicken small intestinal epithelial cells[J].Acta Veterinaria et Zootechnica Sinica,2012,43(4):634-641.(in Chinese)
[43]	王云鹤,金鑫,张曼,等.酿酒酵母菌及其灭活菌对绵羊瘤胃外植体β-防御素-1(SBD-1)表达的影响[J].畜牧兽医学报,2019,50(3):581-591.WANG Y H,JIN X,ZHANG M,et al.Effects of Saccharomyces cerevisiae and its inactivated bacteria on the expression of β-defensin-1 in ruminal explants of sheep[J].Acta Veterinaria et Zootechnica Sinica,2019,50(3):581-591.(in Chinese)
[44]	MAO X B,QI S,YU B,et al.Zn2+ and L-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells[J].Mol Biol Rep,2013,40(2):1547-1552.
[45]	REN M,CAI S,ZHOU T,et al.Isoleucine attenuates infection induced by E. coli challenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs[J].Food Funct,2019,10(6):3535-3542.
[46]	MAO X B,GU C S,REN M,et al.L-Isoleucine administration alleviates rotavirus infection and immune response in the weaned piglet model[J].Front Immunol,2018,9:1654.
[47]	FEHLBAUM P,RAO M,ZASLOFF M,et al.An essential amino acid induces epithelial β-defensin expression[J].Proc Natl Acad Sci U S A,2000,97(23):12723-12728.
[48]	MAO X B,QI S,YU B,et al.Dietary L-arginine supplementation enhances porcine β-defensins gene expression in some tissues of weaned pigs[J].Livest Sci,2012,148(1-2):103-108.
[49]	LIANG H W,DAI Z L,KOU J,et al.Dietary L-tryptophan supplementation enhances the intestinal mucosal barrier function in weaned piglets:implication of tryptophan-metabolizing microbiota[J].Int J Mol Sci,2018,20(1):20.
[50]	汪以真,王静华,林文学,等.不同锌源对断奶仔猪抗菌肽PR-39 mRNA表达的影响[J].中国兽医学报,2005,25(5):523-526.WANG Y Z,WANG J H,LIN W X,et al.Effect of different source of zinc on antibacterial peptide PR-39 gene expression in weaning piglets[J].Chinese Journal of Veterinary Science,2005,25(5):523-526.(in Chinese)
[51]	赵燕飞,汪以真,林文学.锌对断奶后不同阶段仔猪抗菌肽PR-39 mRNA表达的影响[J].中国兽医杂志,2005,41(4):10-13.ZHAO Y F,WANG Y Z,LIN W X.The effect of zinc on expression of antibacterial peptide PR-39 in different stage of weanling pigs[J].Chinese Journal of Veterinary Medicine,2005,41(4):10-13.(in Chinese)
[52]	WEISS S T,LITONJUA A A.Vitamin D in host defense:implications for future research[J].Am J Respir Cell Mol Biol,2017,56(6):692-693.
[53]	张龙.禽宿主防御肽基因进化及其受丁酸和1,25(OH)2D3诱导表达研究[D].成都:四川农业大学,2017.ZHANG L.Molecular evolution of avian host defense peptides and their expression induced by butyrate and 1,25(OH)2D3[D].Chengdu:Sichuan Agricultural University,2017.(in Chinese)
[54]	LU L,LI S M,ZHANG L,et al.Expression of β-defensins in intestines of chickens injected with vitamin D3and lipopolysaccharide[J].Genet Mol Res,2015,14(2):3330-3337.
[55]	DESBOIS A P,SMITH V J.Antibacterial free fatty acids:activities,mechanisms of action and biotechnological potential[J].Appl Microbiol Biotechnol,2010,85(6):1629-1642.
[56]	SCHULTHESS J,PANDEY S,CAPITANI M,et al.The short chain fatty acid butyrate imprints an antimicrobial program in macrophages[J].Immunity,2019,50(2):432-445.e7.
[57]	DOU X,HAN J,SONG W,et al.Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon Toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cell[J].Oncotarget,2017,8(16):26532-26551.
[58]	艾红英,彭富强,黄娟,等.益生菌益生作用的新机制——作为肠道抗菌肽分泌的促进剂[J].中国兽医学报,2016,36(6):1076-1080.AI H Y,PENG F Q,HUANG J,et al. A new mechanism of probiotics——as a promoter of intestinal antimicrobial peptide secretion[J].Chinese Journal of Veterinary Science,2016,36(6):1076-1080.(in Chinese)
[59]	REN M,ZHANG S H,LIU X T,et al.Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the Sirt1/ERK/90RSK pathway[J].J Agric Food Chem,2016,64(17):3371-3379.
[60]	WINTERGERST E S,MAGGINI S,HORNIG D H.Contribution of selected vitamins and trace elements to immune function[J].Ann Nutr Metab,2007,51(4):301-323.
[61]	LIU P,PIEPER R,TEDIN L,et al.Effect of dietary zinc oxide on jejunal morphological and immunological characteristics in weaned piglets[J].J Anim Sci,2014,92(11):5009-5018.
[62]	PIGEON C,ILYIN G,COURSELAUD B,et al.A new mouse liver-specific gene,encoding a protein homologous to human antimicrobial peptide hepcidin,is overexpressed during iron overload[J].J Biol Chem,2001,276(11):7811-7819.
[63]	WANG Y,SHAN T,XU Z,et al.Effect of lactoferrin on the growth performance,intestinal morphology and expression of PR-39 and protegrin-1 genes in weaned piglets[J].J Anim Sci,2006,84(10):2636-2641.
[64]	KRISANAPRAKORNKIT S, JOTIKASTHIRA D, DALE B A. Intracellullar calcium in signaling human β-defensin-2 expression in oral epithelial cells[J]. J Dent Res, 2003,82(11):877-882.
[65]	HARDER J,MEYER-HOFFERT U,WEHKAMP K,et al.Differential gene induction of human β-defensins (hBD-1,-2,-3,and -4) in keratinocytes is inhibited by retinoic acid[J].J Invest Dermatol,2004,123(3):522-529.

Regulation of Nutrients on the Expression of Endogenous Host Defense Peptide in Animals

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