肠道菌群抗病毒机制研究进展

doi:10.11843/j.issn.0366-6964.2023.12.003

Abstract

Abstract: In recent years, with the deepening research on the intestinal microbiota and a clearer understanding of its relationship with organismal health, it has been found that the intestinal microbiota plays a dual role in regulating viral infections. The intestinal microbiota can inhibit viral infection by protecting the intestinal mucosal barrier, directly neutralizing viruses or preventing their effects on cell adhesion, indirectly influencing the establishment and development of the body's immune system, and secreting antiviral metabolites to play an antiviral role. Moreover, probiotics have played an increasingly prominent role in disease treatment, and it is expected that probiotics can overcome the disadvantages of current viral disease treatments. This paper reviews the research progress on the mechanisms of the intestinal microbiota's resistance to viral infection in recent years and discusses related issues and future directions for research.

Key words: intestinal microflora, antivirus mechanism, mucosal barrier, immunomodulation, microbial metabolites

CLC Number:

S852.4

GONG Haoyang, WU Jiaxin, YANG Xiaoyu, XIE Weichun, WANG Xueying, LI Jiaxuan, JIANG Yanping, CUI Wen, LI Yijing, TANG Lijie. Research Progress in Antiviral Mechanism of Intestinal Microflora[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 4910-4919.

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Research Progress in Antiviral Mechanism of Intestinal Microflora

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