牛超数排卵重组促卵泡素研究进展及其应用

doi:10.11843/j.issn.0366-6964.2025.05.006

Abstract

Abstract:

Superovulation serves as a pivotal technology in bovine embryo in vivo production, constituting a vital method for embryo in vivo procurement and forming the foundation for various other embryonic engineering techniques. During the process of superovulation, a plethora of reproductive hormones are employed to foster follicular development and ovulation, among which follicle-stimulating hormone (FSH) is one of the most crucial and central hormones. In recent years, there has been a decline in the production of pituitary-derived FSH while the market demand for FSH continues to escalate. This discrepancy has prompted an increasing number of researchers to focus on the development of recombinant FSH and its efficacy in bovine superovulation. This review is grounded in the theoretical foundations of FSH protein structure and protein engineering, presenting the evolution of recombinant FSH and summarizing the research advancements concerning the application of recombinant FSH in bovine superovulation over the past decade, both domestically and internationally. Furthermore, it delves into potential areas of interest within the field of bovine superovulation. The aim is to provide valuable insights for the establishment of an efficient superovulation protocol utilizing recombinant FSH.

Key words: bovine, superovulation, recombinant FSH, embryo engineering

CLC Number:

S823.3

XIONG Keng, FAN Haojie, WANG Jie, ZHAO Shanjiang, ZHU Qingli, HU Zhihui, LUO Haoshu, ZHU Huabin. Recent Advances and Applications of Recombinant Follicle-Stimulating Hormone in Bovine Superovulation[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(5): 2047-2055.

Figures/Tables 3

Fig. 1

Fig. 2

Table 1

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品种 Breed	FSH种类 Type of FSH	超排用量 Dosage of superovulation	头均可用胚胎数/枚 Number of available embryos per donor
中国荷斯坦牛Chinese Holstein	中科院垂体FSH	8~10 mg	6.36^[25]
文山牛Wenshan cattle	日本产FSH	22 AU	7.83^[26]
澳洲和牛Australian Wagyu	Folltropin-V	240 mg	10.2^[28]
和牛Wagyu	Folltropin-V	120 mg	6.10^[29]
比利时蓝白花牛Belgian Blue	Folltropin-V	700 IU	5.50^[30]
南阳牛Nanyang cattle	Folltropin-V	340 mg	3.32^[31]
西门塔尔牛Simmental	宁波第二激素厂FSH	150 IU	4.94^[32]
南阳牛Nanyang cattle	Folltropin-V	未给出	7.71^[33]
复州牛Fuzhou cattle	中科院垂体FSH	8.8 mg	7.38^[35]
复州牛Fuzhou cattle	日本产FSH	24 AU	7.50^[35]

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Recent Advances and Applications of Recombinant Follicle-Stimulating Hormone in Bovine Superovulation

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