伪狂犬病病毒编码的内膜蛋白生物学功能研究进展

doi:10.11843/j.issn.0366-6964.2024.03.010

Abstract

Abstract: Pseudorabies virus (PRV) belongs to the α-herpesvirus subfamily, which can infect the host nervous system and establish latent infection in neurons, and PRV is an important pathogen threatening the global swine industry. Similar to other α-herpesviruses, the virion of PRV has a protein-rich inner membrane layer that links the DNA-containing capsids to the glycoprotein filled envelope layer to form the complete structure of the virion. Studies have shown that during the infection cycle of PRV, tegument proteins can play important biological functions in maintaining the stability of the morphological structure of the virus, promoting the replication and nuclear egress of the virus, participating in the secondary envelopment of the virus in the cytoplasm, and fighting against the host immune system by acting alone or interacting with other proteins. Therefore, this paper focuses on the recent research progress on the biological functions of PRV tegument proteins, in order to provide important references for the etiology and antiviral research of pseudorabies virus.

Key words: pseudorabies virus, tegument proteins, biological functions

CLC Number:

S852.659.1

LI Yixuan, NIU Jingyi, LI Gang, WAN Chao, FANG Rendong, YE Chao. Research Progress on the Biological Functions of Tegument Proteins Encoded by Pseudorabies Virus[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 957-970.

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Research Progress on the Biological Functions of Tegument Proteins Encoded by Pseudorabies Virus

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[1]	CHEN Hongjian, CAO Yan, FAN Jie, GAN Rongxuan, SONG Wenbo, YU Shengwei, YANG Ting, ZHAO Yanxia, WEI Chunyan, XIE Rui, HUA Lin, PENG Zhong, WU Bin. Prevalence and Phylogenetic Analysis of Pseudorabies Virus within Pig Slaughterhouses in Hubei Province of China during 2020-2022 [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2972-2981.
[2]	YUAN Sheng, LI Anqi, Lü Wenke, YANG Lulu, ZHOU Feng, HUANG Liangzong, BAI Aiquan, WEN Feng, HUANG Shujian, GUO Jinyue. Analysis of Variation in Major Virulence-related Genes of a Strain of Pseudorabies Virus and Its Pathogenicity to Rabbits [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2195-2199.
[3]	NI Zheng, YE Weicheng, CHEN Liu, YUN Tao, HUA Jionggang, ZHU Yinchu, ZHANG Cun. Genetic Variation and Pathogenicity of a Pseudorabies Virus Variant Strain in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1766-1770.
[4]	WU Xuemin, CHEN Rujing, CHEN Qiuyong, CHE Yongliang, YAN Shan, LIU Yutao, ZHOU Lunjiang, WANG Longbai. Establishment and Preliminary Application of Indirect ELISA for Detection of Variant Pseudorabies Virus gC Antibody [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 2029-2034.
[5]	LI Zhaolong, ZHANG Huifang, FENG Zhihua, FANG Zhou. Therapeutic Effect of Recombinant Adeno-Associated Virus Carrying CRISPR/Cas9 on Pseudorabies Virus-infected Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(3): 834-846.
[6]	GUO Zhenhua, LI Xiang, WENG Maoyang, JIN Qianyue, GUO Junqing, XING Guangxu, ZHANG Gaiping. Host Annexin A2 Interacts with US3 of PRV and Its Effects on Apoptosis [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3927-3935.
[7]	WANG Jiamin, LI Ziliang, MA Fangfang, KANG Bijing, TIAN Ling, LI Zhuo, MA Zhongren, QIAO Zilin. Optimization of BHK-21 Suspension Cells to Propagate Pseudorabies Virus in Bioreactor [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3936-3947.
[8]	LI Chen, HE Wenfeng, ZHAO Lina, FAN Qi, YANG Guoqing, LIU Huimin. Effect of Interferon Stimulated Gene 15 Knockout in PK-15 Cell Line on Replication of Pseudorabies Virus [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3621-3630.
[9]	ZHAI Yunyun, LI Jiajia, ZHANG Shuang, REN Ziyu, JIN Qianyue, DU Yongkun, WAN Bo. Establishment of Apoptosis Associated Dot Like Protein Knockout PK-15 Cell Line and Its Effect on Porcine Pseudorabies Virus Infection [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(2): 478-487.
[10]	ZHAO Shuo, WANG Ruomu, DANG Jiajia, XU Lishi, QIN Shuying, XUE Hui, WEI Zuzhang, CHEN Ying, OUYANG Kang, HUANG Weijian. Genetic Variation Analysis of gB, gE and TK Genes of Pseudorabies Virus in Guangxi from 2013 to 2018 [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(4): 810-819.
[11]	MA Zhenyuan, WANG Shujuan, YAN Ruoqian, BAN Fuguo, ZHAO Xueli, XIE Caihua, WANG Huajun, WANG Dongfang. Establishment of Competitive Chemiluminescent Enzyme Immunoassay for Detecting Antibodies against gB Protein of Pseudorabies Virus [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 574-583.
[12]	SUN Ying, WANG Xueying, LIANG Wan, XIE Sisi, PENG Zhong, CHEN Hongjian, HUA Lin, SONG Wenbo, TANG Xibiao, CHEN Huanchun, WU Bin. Epidemiological and Evolutionary Characteristics of Pseudorabies Virus in China in 2018 [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 584-593.
[13]	FANG Juan, CHEN Zhilong, LI Chen, ZHANG Feng, WU Xiaosong, YANG Qing. Effect of Porcine Pseudorabies Virus Infection on Proliferation of PK-15 Cell and Expression of Heat Shock Protein 27,70 and 90 [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(7): 1441-1448.
[14]	LIU Xiaohe, BA Gen, LI Jian, HAN Yingqian, ZHANG Shuang, MING Shengli, DU Yongkun, CHU Beibei, YANG Guoyu, WANG Jiang. Genetic Knockout of TANK-binding Kinase 1 Gene in PK-15 Cells Promotes Pseudorabies Virus Replication [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(6): 1239-1248.
[15]	HOU Lu, WANG Yi, ZHANG Shuang, LI Guoli, ZENG Lei, GUO Yukun, ZHAI Yunyun, YU Pengwei, WANG Qi, WANG Chunfeng, DU Yongkun, WAN Bo. Effect of Interferon Gene Stimulating Factor Gene Knockout on Replication of Porcine Pseudorabies Virus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2273-2282.