弓形虫致密颗粒蛋白的生物学功能研究进展

doi:10.11843/j.issn.0366-6964.2022.10.008

Abstract

Abstract: Toxoplasma gondii is an important zoonotic parasite with a wide range of intermediate hosts, complex life history, diverse modes of transmission and global distribution, which can infect almost all warm-blood animals, including humans, causing zoonotic toxoplasmosis. About one third of the world human population are chronically infected with T. gondii, which poses a serious health threat to immune deficiency patients, pregnant women and pregnant animals. Therefore, T. gondii is an important zoonotic parasite. Dense granule protein family secreted by the dense granules, one of the important subcellular secretory organelles of T. gondii, plays important roles in many biological processes, such as regulating the host cell cycle and immune response by modulating the signal pathways, gene expression, participating in the protein transport and localization, nutrient uptake, the formation and stability maintenance of intravacuolar network (IVN), as well as egress and chronic infection of T. gondii. In this review, the basic biological functions of the dense granule proteins are summarized in order to provide new research ideas for the pathogenesis of T. gondii, the discovery of potential drug targets against T. gondii and the development of anti-T. gondii vaccines.

Key words: Toxoplasma gondii, toxoplasmosis, dense granule proteins, biological function

CLC Number:

ZHENG Xiaonan, LI Tingting, WANG Jinlei, ZHENG Wenbin, ZHU Xingquan. Research Progress on Biological Functions of Dense Granule Proteins of Toxoplasma gondii[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3345-3357.

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Research Progress on Biological Functions of Dense Granule Proteins of Toxoplasma gondii

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