DNA甲基化在哺乳动物卵母细胞和早期胚胎发育中的研究进展

doi:10.11843/j.issn.0366-6964.2023.02.003

Abstract

Abstract: DNA methylation is a dynamic, reversible and heritable epigenetic modification pattern that mainly occurs in mammalian primordial germ cells and early embryonic development. DNA methylation can attach to the CpG region of DNA through highly dynamic and cooperative ribozyme networks, and it can also regulate gene expression by altering functional state of the regulatory regions without affecting genetic information carried by the DNA sequence. DNA methylation is mainly involved in a variety of key physiological processes such as genomic imprinting, transposable element silencing, X-chromosome inactivation and senescence, and plays an important role in mammalian oocyte and embryo development. This review introduces the establishment and removal mechanism of DNA methylation and the biological functions, with emphasis on the dynamic processes of precise generation, maintenance, reading and deletion of DNA methylation during mammalian oocyte and embryo development, providing basis for further studies on mammalian epigenetic regulation.

Key words: DNA methylation, oocyte, embryonic development, epigenetics

CLC Number:

S813.1

YANG Xiaogeng, ZHANG Huizhu, LI Jian, XIANG Hua, HE Honghong. Research Progress of the DNA Methylation in Mammalian Oocyte and Early Embryo Development[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 443-450.

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Research Progress of the DNA Methylation in Mammalian Oocyte and Early Embryo Development

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