猪繁殖与呼吸综合征抗病育种研究进展

doi:10.11843/j.issn.0366-6964.2023.02.002

Abstract

Abstract: Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious infectious disease caused by porcine reproductive and respiratory syndrome virus (PRRS virus, PRRSV), which seriously endangers the pig industry in China and even the world. However, due to the variability of PRRSV antigen, the current prevention and control measures, including vaccination and drug treatment, are ineffective. Therefore, with the continuous development of modern molecular biology technology, the disease-resistant breeding of PRRS in pigs based on gene editing technology has gradually developed. This paper briefly describes the clinical symptoms of PRRS, and focuses on the research progress of PRRS disease-resistance breeding at home and abroad. By analyzing the pathogenic mechanism of PRRSV, the PRRSV receptors and the in vivo and in vitro antiviral effects of editing against different receptors were emphasized to provide a theoretical basis for further research of the pathogenic mechanism of PRRSV and the development of PRRS-resistant varieties in the future.

Key words: porcine reproductive and respiratory syndrome, pathogenic mechanisms, disease-resistance breeding, CD163, HDAC6, gene editing

CLC Number:

S813.3

LIU Ling, WANG Dandan, CUI Kai, MA Yuehui, JIANG Lin. Advances of Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 434-442.

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Advances of Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome

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