非洲猪瘟血清学诊断靶点的研究进展

doi:10.11843/j.issn.0366-6964.2021.05.007

Abstract

Abstract: African swine fever (ASF) is a highly fatal infectious disease caused by African swine fever virus (ASFV) in pigs. The proteins p30, p54 and p72 encoded by ASFV have high immunogenicity and some amino acid sequences are conserved, so they are often used as serological diagnostic targets to evaluate the changes of antibody levels through different stages or degrees of ASFV infection. In-depth study of ASF serological diagnostic targets would be helpful to explore its infection detection, pathogenic mechanism and immune system response. This paper systematically reviewed the progress in the detection of main candidate proteins and their targets for serological diagnosis of ASF, analyzed the antigenic epitopes (regions) of candidate targets and the characteristics of antibody binding, and discussed their application potential as new targets for serological diagnosis of ASF.

Key words: African swine fever virus, diagnostic targets, structural proteins, antigenic epitopes

CLC Number:

S852.659.1

YANG Wenbing, ZOU Yawen, JIANG Yifan, YU Wanting, YANG Yi, WU Jing, WANG Naidong. Advances Research on African Swine Fever Serological Diagnostic Targets[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(5): 1208-1217.

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Advances Research on African Swine Fever Serological Diagnostic Targets

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