NF-κB信号通路调控奶牛乳腺炎的分子作用机制

doi:10.11843/j.issn.0366-6964.2021.010.005

Abstract

Abstract: Mastitis is usually an inflammatory reaction of mammary gland caused by microbial infection, and is one of the most common diseases of dairy cows, which can lead to the decline of milk yield and quality, reduce the productive life of dairy cows, and seriously affect the economic benefits of pasture. In recent years, scholars have carried out a lot of researches on the molecular regulation mechanism of dairy cow mastitis, and found that NF-κB and its signaling pathway can participate in regulating the expression of many immune related genes, and play a key role in the process of cellular inflammatory response and immune response, which is also a hotspot in the research of dairy cow mastitis. This paper reviewed the etiology and pathological changes of dairy cow mastitis, as well as the relationship between NF-κB signaling pathway and body immunity, and the latest research progress of the molecular mechanism of regulating dairy cow mastitis by mRNA, non-coding RNA (miRNA, lncRNA and circRNA) and bioactive substances through NF-κB signaling pathway, which will provide the reference for the analysis of molecular regulatory network of mastitis, molecular breeding of anti-mastitis, and the development of bioactive drugs for treatment of dairy cow mastitis.

Key words: dairy cow, mastitis, NF-κB signaling pathway, non-coding RNA, bioactive substance

CLC Number:

S823.9

LI Yuhang, LUORENG Zhuoma, WANG Xingping, YANG Jian, MA Yun, WEI Dawei. Molecular Regulatory Mechanism of NF-κB Signaling Pathway Regulating Mastitis in Dairy Cows[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(10): 2740-2752.

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Molecular Regulatory Mechanism of NF-κB Signaling Pathway Regulating Mastitis in Dairy Cows

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