热应激导致奶牛胚胎质量下降的机制及解决措施

doi:10.11843/j.issn.0366-6964.2023.03.002

Abstract

Abstract: Dairy products are an important source of high quality protein supplement in people’s lives, with high nutritional value and many health benefits. The increasing consumer demand for dairy products has brought opportunities and challenges to dairy production, and improving the productivity of dairy cows has become a hot research topic. However, modern dairy production faces many dilemmas, such as heat stress in dairy cows due to high summer temperatures, resulting in reduced fertility. Heat stress in dairy cows has adverse effects on embryo quality, including embryonic cell cycle progression and cell survival, resulting in lower embryo quality and reduced productivity. In addition, abnormal epigenetic modifications are another mechanism by which heat stress in cows affects embryo quality, mainly including abnormal histone modifications and abnormal DNA methylation. Numerous studies have shown that restoration of cellular mitochondrial function and the use of melatonin can effectively mitigate the adverse effects of heat stress on embryos. Therefore, this paper outlines the mechanisms by which heat stress leads to abnormal epigenetic modifications in embryos and thus decreases embryo quality, and two solutions to mitigate heat stress by mitochondrial transplantation and melatonin treatment to improve embryo quality, thus contributing to improve the productivity of dairy cows, with the aim of providing a reference for reducing the losses caused by heat stress in animal husbandry.

Key words: heat stress, dairy cows, embryo quality, mechanism, solution

CLC Number:

S823.3

FENG Xiaoyi, YANG Baigao, HAO Haisheng, DU Weihua, ZHU Huabin, CUI Kai, ZHAO Xueming. Mechanism and Solution of Heat Stress Induced Embryo Quality Decline in Dairy Cows[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 868-876.

References 63

[1]	FEIL A A,SCHREIBER D,HAETINGER C,et al.Sustainability in the dairy industry:a systematic literature review[J].Environ Sci Pollut Res Int,2020, 27(27):33527-33542.
[2]	WANG M Q,IBEAGHA-AWEMU E M.Impacts of epigenetic processes on the health and productivity of livestock[J].Front Genet,2021,11:613636.
[3]	COLLIER R J,DAHL G E,VANBAALE M J.Major advances associated with environmental effects on dairy cattle[J].J Dairy Sci,2006,89(4):1244-1253.
[4]	CHEN K L,WANG H L,JIANG L Z,et al.Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells[J].In Vitro Cell Dev Biol Anim,2020,56(4):322-331.
[5]	DOS SANTOS M M,SOUZA-JUNIOR J B F,DANTAS M R T,et al.An updated review on cattle thermoregulation:physiological responses,biophysical mechanisms,and heat stress alleviation pathways[J].Environ Sci Pollut Res Int,2021,28(24):30471-30485.
[6]	KAMAL R,DUTT T,PATEL M,et al.Heat stress and effect of shade materials on hormonal and behavior response of dairy cattle:a review[J].Trop Anim Health Prod,2018,50(4):701-706.
[7]	LIU S J,DE JONGE J,TREJO-ARELLANO M S,et al.Role of H1 and DNA methylation in selective regulation of transposable elements during heat stress[J].New Phytol,2021,229(4):2238-2250.
[8]	BOUROUTZIKA E,KOURETAS D,PAPADOPOULOS S,et al.Effects of melatonin administration to pregnant ewes under heat-stress conditions,in redox status and reproductive outcome[J].Antioxidants (Basel),2020,9(3):266.
[9]	SAMMAD A,WANG Y J,UMER S,et al.Nutritional physiology and biochemistry of dairy cattle under the influence of heat stress:consequences and opportunities[J].Animals (Basel),2020,10(5):793.
[10]	DEL CORVO M,LAZZARI B,CAPRA E,et al.Methylome patterns of cattle adaptation to heat stress[J].Front Genet,2021, 12:633132.
[11]	DE BARROS F R O,PAULA-LOPES F F.Cellular and epigenetic changes induced by heat stress in bovine preimplantation embryos[J]. Mol Reprod Dev,2018,85(11):810-820.
[12]	OUELLET V,BOUCHER A,DAHL G E,et al.Consequences of maternal heat stress at different stages of embryonic and fetal development on dairy cows'progeny[J].Anim Front,2021,11(6):48-56.
[13]	DE AGUIAR L H,HYDE K A,PEDROZA G H,et al.Heat stress impairs in vitro development of preantral follicles of cattle[J]. Anim Reprod Sci,2020,213:106277.
[14]	GARCIA-ISPIERTO I,ABDELFATAH A,LÓPEZ-GATIUS F.Melatonin treatment at dry-off improves reproductive performance postpartum in high-producing dairy cows under heat stress conditions[J].Reprod Domest Anim,2013,48(4):577-583.
[15]	CHANG-FUNG-MARTEL J,HARRISON M T,BROWN J N,et al.Negative relationship between dry matter intake and the temperature-humidity index with increasing heat stress in cattle:a global meta-analysis[J].Int J Biometeorol,2021,65(12):2099-2109.
[16]	ZHANG M H,DUNSHEA F R,WARNER R D,et al.Impacts of heat stress on meat quality and strategies for amelioration:a review[J].Int J Biometeorol,2020,64(9):1613-1628.
[17]	NEGRÓN-PÉREZ V M,FAUSNACHT D W,RHOADS M L.Invited review:management strategies capable of improving the reproductive performance of heat-stressed dairy cattle[J].J Dairy Sci,2019,102(12):10695-10710.
[18]	CEBRIAN-SERRANO A,SALVADOR I,RAGA E,et al.Beneficial effect of melatonin on blastocyst in vitro production from heat-stressed bovine oocytes[J].Reprod Domest Anim,2013,48(5):738-746.
[19]	BERMAN A.An overview of heat stress relief with global warming in perspective[J].Int J Biometeorol,2019,63(4):493-498.
[20]	SAKATANI M.Effects of heat stress on bovine preimplantation embryos produced in vitro[J].J Reprod Dev,2017,63(4):347-352.
[21]	PAYTON R R,RISPOLI L A,NAGLE K A,et al.Mitochondrial-related consequences of heat stress exposure during bovine oocyte maturation persist in early embryo development[J].J Reprod Dev,2018,64(3):243-251.
[22]	ROTH Z.Symposium review:reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function[J].J Dairy Sci,2018,101(4):3642-3654.
[23]	DE CASTRO CAVALLARI F,LEAL C L V,ZVI R,et al.Effects of melatonin on production of reactive oxygen species and developmental competence of bovine oocytes exposed to heat shock and oxidative stress during in vitro maturation[J].Zygote, 2019,27(3):180-186.
[24]	ORTEGA M S,ROCHA-FRIGONI N A S,MINGOTI G Z,et al.Modification of embryonic resistance to heat shock in cattle by melatonin and genetic variation in HSPA1L[J].J Dairy Sci,2016,99(11):9152-9164.
[25]	RATCHAMAK R,THANANURAK P,BOONKUM W,et al.The melatonin treatment improves the ovarian responses after superstimulation in Thai-Holstein crossbreeds under heat stress conditions[J].Front Vet Sci,2022,9:888039.
[26]	KANEKO H,IGARASHI K,KATAOKA K,et al.Heat shock induces phosphorylation of histone H2AX in mammalian cells[J].Biochem Biophys Res Commun,2005,328(4):1101-1106.
[27]	PÖHLAND R,SOUZA-CÁCARES M B,DATTA T K,et al.Influence of long-term thermal stress on the in vitro maturation on embryo development and heat shock protein abundance in zebu cattle[J].Anim Reprod,2020,17(3):e20190085.
[28]	YAACOBI-ARTZI S,SHIMONI C,KALO D,et al.Melatonin slightly alleviates the effect of heat shock on bovine oocytes and resulting blastocysts[J].Theriogenology,2020,158:477-489.
[29]	DIAZ F A,GUTIERREZ-CASTILLO E J,FOSTER B A,et al.Evaluation of seasonal heat stress on transcriptomic profiles and global DNA methylation of bovine oocytes[J].Front Genet,2021,12:699920.
[30]	PAVANI K,CARVALHAIS I,FAHEEM M,et al.Reproductive performance of holstein dairy cows grazing in dry-summer subtropical climatic conditions:effect of heat stress and heat shock on meiotic competence and in vitro fertilization[J].Asian-Australas J Anim Sci,2015,28(3):334-342.
[31]	AMARAL C S,KOCH J,CORREA JÚNIOR E E,et al.Heat stress on oocyte or zygote compromises embryo development,impairs interferon tau production and increases reactive oxygen species and oxidative stress in bovine embryos produced in vitro[J].Mol Reprod Dev,2020,87(8):899-909.
[32]	WU J,ZHANG W W,LI C H.Recent advances in genetic and epigenetic modulation of animal exposure to high temperature[J]. Front Genet,2020,11:653.
[33]	STINSHOFF H,WILKENING S,HANSTEDT A,et al.Cryopreservation affects the quality of in vitro produced bovine embryos at the molecular level[J].Theriogenology,2011,76(8):1433-1441.
[34]	ZHU J Q,LIU J H,LIANG X W,et al.Heat stress causes aberrant DNA methylation of H19 and Igf-2r in mouse blastocysts[J].Mol Cells,2008,25(2):211-215.
[35]	SHI L J,WU J.Epigenetic regulation in mammalian preimplantation embryo development[J].Reprod Biol Endocrinol,2009,7:59.
[36]	CHEN H H,ZHANG L,DENG T F,et al.Effects of oocyte vitrification on epigenetic status in early bovine embryos[J]. Theriogenology,2016,86(3):868-878.
[37]	ZHANG Y J,SUN Z X,JIA J Q,et al.Overview of histone modification[J].Adv Exp Med Biol,2021,1283:1-16.
[38]	DEL CORVO M,BONGIORNI S,STEFANON B,et al.Genome-wide DNA methylation and gene expression profiles in cows subjected to different stress level as assessed by cortisol in milk[J].Genes (Basel),2020,11(8):850.
[39]	RACEDO S E,WRENZYCKI C,LEPIKHOV K,et al.Epigenetic modifications and related mRNA expression during bovine oocyte in vitro maturation[J].Reprod Fertil Dev,2009,21(6):738-748.
[40]	WU X,LI Y,XUE L,et al.Multiple histone site epigenetic modifications in nuclear transfer and in vitro fertilized bovine embryos[J].Zygote,2011,19(1):31-45.
[41]	WU X,HU S X,WANG L L,et al.Dynamic changes of histone acetylation and methylation in bovine oocytes,zygotes,and preimplantation embryos[J].J Exp Zool B Mol Dev Evol,2020,334(4):245-256.
[42]	MASON K,LIU Z C,AGUIRRE-LAVIN T,et al.Chromatin and epigenetic modifications during early mammalian development[J]. Anim Reprod Sci,2012, 134(1-2):45-55.
[43]	DE LA FUENTE R.Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes[J].Dev Biol,2006,292(1):1-12.
[44]	KUBICEK S,JENUWEIN T.A crack in histone lysine methylation[J].Cell,2004,119(7):903-906.
[45]	SINGH K,MOLENAAR A J,SWANSON K M,et al.Epigenetics:a possible role in acute and transgenerational regulation of dairy cow milk production[J].Animal,2012,6(3):375-381.
[46]	THOMPSON R P,NILSSON E,SKINNER M K.Environmental epigenetics and epigenetic inheritance in domestic farm animals[J]. Anim Reprod Sci,2020,220:106316.
[47]	FU G,GHADAM P,SIROTKIN A,et al.Mouse oocytes and early embryos express multiple histone H1 subtypes[J].Biol Reprod, 2003,68(5):1569-1576.
[48]	KIMURA H,HAYASHI-TAKANAKA Y,YAMAGATA K.Visualization of DNA methylation and histone modifications in living cells[J].Curr Opin Cell Biol,2010,22(3):412-418.
[49]	DUAN J,ZHU L,DONG H,et al.Analysis of mRNA abundance for histone variants,histone-and DNA-modifiers in bovine in vivo and in vitro oocytes and embryos[J].Sci Rep,2019,9(1):1217.
[50]	MUSHTAQ A,MIR U S,HUNT C R,et al.Role of histone methylation in maintenance of genome integrity[J].Genes (Basel),2021, 12(7):1000.
[51]	MCGRAW S,VIGNEAULT C,TREMBLAY K,et al.Characterization of linker histone H1FOO during bovine in vitro embryo development[J].Mol Reprod Dev,2006,73(6):692-699.
[52]	XU R M,LI C,LIU X Y,et al.Insights into epigenetic patterns in mammalian early embryos[J].Protein Cell,2021,12(1):7-28.
[53]	SHAO G B,DING H M,GONG A H.Role of histone methylation in zygotic genome activation in the preimplantation mouse embryo[J].In Vitro Cell Dev Biol Anim,2008,44(3-4):115-120.
[54]	CAO P B,LI H S,ZUO Y C,et al.Characterization of DNA methylation patterns and mining of epigenetic markers during genomic reprogramming in SCNT embryos[J].Front Cell Dev Biol,2020,8:570107.
[55]	SALILEW-WONDIM D,SAEED-ZIDANE M,HOELKER M,et al.Genome-wide DNA methylation patterns of bovine blastocysts derived from in vivo embryos subjected to in vitro culture before,during or after embryonic genome activation[J].BMC Genomics,2018,19(1):424.
[56]	DUAN J E,JIANG Z C,ALQAHTANI F,et al.Methylome dynamics of bovine gametes and in vivo early embryos[J].Front Genet, 2019,10:512.
[57]	HUA S,ZHANG Y,LI X C,et al.Effects of granulosa cell mitochondria transfer on the early development of bovine embryos in vitro[J].Cloning Stem Cells,2007,9(2):237-246.
[58]	CAGNONE G L M,TSAI T S,MAKANJI Y,et al.Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency[J].Sci Rep,2016,6:23229.
[59]	YANG L,ZHAO Z M,CUI M S,et al.Melatonin Restores the Developmental competence of heat stressed porcine oocytes,and alters the expression of genes related to oocyte maturation[J].Animals (Basel),2021,11(4):1086.
[60]	MARQUES T C,DA SILVA SANTOS E C,DIESEL T O,et al.Melatonin reduces apoptotic cells,SOD2 and HSPB1 and improves the in vitro production and quality of bovine blastocysts[J].Reprod Domest Anim,2018,53(1):226-236.
[61]	MANJUNATHA B M,DEVARAJ M,GUPTA P S P,et al.Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development[J].Reprod Domest Anim,2009,44(1):12-16.
[62]	RODRIGUEZ-OSORIO N,KIM I J,WANG H,et al.Melatonin increases cleavage rate of porcine preimplantation embryos in vitro[J].J Pineal Res,2007,43(3):283-288.
[63]	ISHIZUKA B,KURIBAYASHI Y,MURAI K,et al.The effect of melatonin on in vitro fertilization and embryo development in mice[J].J Pineal Res,2000,28(1):48-51.

Mechanism and Solution of Heat Stress Induced Embryo Quality Decline in Dairy Cows

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 63

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	XIAO Yimei, WANG Shengnan, XU Yuewen, HE Xiaolin, YIN Fuquan. Research on the Influence of Heat Stress on Male Reproduction [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 11-21.
[2]	WANG Siying, ZOU Hong, SONG Zhenhui. The Role of Na⁺/H⁺ Exchanger Isoform 3 in Infectious Diarrhea and Its Activity Regulation Mechanism [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3230-3241.
[3]	ZHANG Xumei, WEI Yurong, XU Chenghui, YANG Tong, SHI Huijun, FU Qiang, YANG Li. To Analyze the Mechanism of Berberine in the Treatment of Salmonella Gallinarum Infection Based on Network Pharmacology and Experimental Verification [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3557-3570.
[4]	ZHANG Hang, YANG Baigao, XU Xi, FENG Xiaoyi, DU Weihua, HAO Haisheng, ZHU Huabin, ZHANG Peipei, ZHAO Xueming. Research Progress on the Mechanism of Heat Stress Affecting the Development of Dairy Cow Embryos [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2692-2700.
[5]	ZHAO Wanli, CAO Qiqi, YANG Yue, DENG Zhaoju, XU Chuang. The Interaction between Gastrointestinal Microbiota and Mucosal Immunity in Health of Perinatal Dairy Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2751-2760.
[6]	ZHOU Weiwei, WANG Xuefeng, ZHANG Mengjie, YANG Juan, SUN Yuelong, ZHANG Zufeng, ZHANG Yuxin, DOU Jiahong, WANG Ziying, DAI Xiaofeng, LI Xiumei. Analysing the Mechanism of Sihuang Zhili Granule in the Treatment of Piglet Diarrhea Based on Biological Network Function Modules and Compatibility Rules [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 3031-3043.
[7]	AN Zongqi, ZHAN Siyuan, LI Li, ZHANG Hongping. ceRNA-mediated Function of CircRNA on Critical Economic Traits in Animals [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2215-2222.
[8]	FENG Weimin, LIU Xiao, HUANG Teng. The Evasion Strategy against CTL Recognition by Herpesviruses of Domestic Animals: Interference with MHC Class Ⅰ Antigen Presentation Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2241-2251.
[9]	LI Zhaoyan, GAO Jiang, GUO Shihui, ZHAO Ruqian, MA Wenqiang. Advances in Detection Methods and Control Solutions for Feline Allergens [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2272-2279.
[10]	LONG Qinqin, WEI Min, WANG Yuting, WEN Ming, PANG Feng. The Battle between Orf Virus and Host: Immune Response and Viral Immune Evasion Mechanisms [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1845-1853.
[11]	WANG Zixuan, WANG Qiao, ZHANG Jin, Astrid Lissette Barreto Sánchez, ZHENG Maiqing, LI Qinghe, CUI Huanxian, AN Bingxing, ZHAO Guiping, WEN Jie, LI Hegang. Transcriptome Based Screening of Functional Genes Related to Heat Stress Resistance in Beijing You Chickens and Guangming Broilers [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1905-1914.
[12]	HUANG Shangzhen, MA Longgang, LOU Wenqi, NING Jingyang, ZHANG Hailiang, HU Lirong, ZHA Qiong, LI Bin, XU Qing, BASANG Luobu, WANG Yachun. Analysis of Influencing Factors on Blood Indicators of Dairy Cows at High-altitude Area [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1964-1978.
[13]	PAN Chanyuan, ZHAO Zixuan, DUAN Mingjie, JIANG Linshu, TONG Jinjin. The Mechanism of Artemisia carvifolia Alleviating Dairy Cow Oxidative Stress Predicted by Network Pharmacology [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1071-1084.
[14]	LIU Ling, WANG Dandan, CUI Kai, MA Yuehui, JIANG Lin. Advances of Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 434-442.
[15]	FAN Lei, SHEN Yu, YOU Liuchao, TIAN Xinyu, LUO Hao, WANG Xin, ZHANG Tingting, SHEN Liuhong. Research Progress on Abnormal Glucose and Lipid Metabolism in Dairy Cows Induced by Lipopolysaccharide (LPS) [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 484-493.