Acta Veterinaria et Zootechnica Sinica ›› 2020, Vol. 51 ›› Issue (12): 2954-2963.doi: 10.11843/j.issn.0366-6964.2020.12.005

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Advances on Virulence Factors of Streptococcus agalactiae of Dairy Cows Mastitis

WU Fuxin1, XIONG Benhai2, TONG Jinjin1*, JIANG Linshu1*   

  1. 1. Beijing Key Laboratory of Dairy Cattle Nutrition, Institute of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China;
    2. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
  • Received:2020-06-29 Online:2020-12-25 Published:2020-12-23

Abstract: Streptococcus, Staphylococcus aureus, and Escherichia coli are the three major pathogens causing mastitis in dairy cows, and Streptococcus agalactiae (S.agalactiae) in Streptoco-ccus is one of the important pathogens causing mastitis in dairy cows, which accounts for around 56.25% of the incidence of sub-clinic mastitis. The process of S.agalactiae invasion mammary glands of dairy cows mainly includes:infection, adhesion, invasion, and then damage the mammary tissue and entail the inflammation. The virulence factor of S. agalactiae has the function of attaching and invading the mammary gland epithelial cells so that the bacteria could form the biofilm on the surface. After infection, the irritation of the mammary tissues by infectious processes serves to the immune response. In this paper, we summarized the types, mechanism, and regulation process of S. agalactiae virulence factors which plays a major role in the invasion of mastitis, aimed to show the activity of S. agalactiae by inhibiting the activity of its related virulence factors in preventing dairy cow mastitis and provide new ideas for the treatment.

Key words: Streptococcus agalactiae, virulence factor, dairy cow, mastitis

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