氨基酸在炎症性肠病中的作用及其信号通路

doi:10.11843/j.issn.0366-6964.2020.10.003

Abstract

Abstract: The intestine is the primary organ responsible for digestion and absorption of nutrients and is frequently subjected to external environmental stimulations leading to the development of inflammatory bowel disease (IBD), which can cause serious harm to intestinal health in animals. Dietary amino acids play important roles in promoting intestinal development and maintaining intestinal health and exert diverse effects through multiple signaling pathways on the prevention and treatment of IBD, including affecting the physiological activities of intestinal epithelial cells, improving intestinal barrier function, reducing intestinal oxidative damage, regulating the production of inflammatory cytokines, and promoting the expression of endogenous antimicrobial peptides, and involved in main signaling pathways including AMP-activated kinase (AMPK), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), Toll-like receptors (TLRs), nucleotide binding oligomerization domain (NOD)/nuclear factor kappa-B (NF-κB). In this review, basic characteristics of IBD, effects and involved signaling pathways of the amino acids on IBD, and effects and applications of amino acids in maintaining intestinal health in livestock and poultry production were reviewed, so as to provide effective clues and strategies for dietary nutrients in the prevention and treatment of IBD.

Key words: amino acids, inflammatory bowel disease, function, signaling pathways

CLC Number:

S811
S856.4

GAO Nan, DOU Xiujing, YANG Yang, SHAN Anshan. Effects of Amino Acids on Inflammatory Bowel Disease and Its Signaling Pathways[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(10): 2349-2358.

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Effects of Amino Acids on Inflammatory Bowel Disease and Its Signaling Pathways

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