CD163基因在猪繁殖与呼吸综合征抗病育种中的研究进展

doi:10.11843/j.issn.0366-6964.2023.08.001

Abstract

Abstract: Scavenger receptor superfamily is a structurally related transmembrane glycoprotein family. Its characteristic component is a highly conserved scavenger receptor cysteine-rich (SRCR) domain. CD163, which is a type B scavenger receptor and has 9 SRCR domains, is highly expressed in monocyte and macrophages. It was reported that CD163 is an essential receptor of porcine reproductive and respiratory syndrome virus (PRRSV), involved in the uncoating process of PRRSV and possibly participated in the attachment and internalization of African swine fever virus (ASFV). In addition, CD163 plays an irreplaceable role in many important biological processes. This review introduces the basic information, physiological functions and research progress of CD163 in pig disease-resistant breeding on PRRSV, providing reference for disease-resistant animal breeding.

Key words: scavenger receptor, CD163, physiological and biochemical function, PRRSV, ASFV

CLC Number:

S828.2

WANG Hui, FENG Baoliang, WU Dan, XIANG Guangming, WANG Nan, MU Yulian, LI Kui, LIU Zhiguo. Research Progress of CD163 Gene and Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3127-3138.

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Research Progress of CD163 Gene and Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome

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