肠道菌群调控动物肠道黏膜免疫和炎症的研究进展

doi:10.11843/j.issn.0366-6964.2024.04.008

Abstract

Abstract: Alterations of the gut microbiota may cause dysregulated mucosal immune responses, leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts. Current effective treatments for IBD in animals are restoration of normal immune homeostasis of the gut microbiota by microbiota-targeted therapies including antibiotics, prebiotics, postbiotics, and fecal microbiota transplantation. In this review, the basis for promoting intestinal homeostatic immune responses through microbiota-targeted therapy, as well as recent advances in host-microbe interactions during the occurrence and development of IBD were discussed. Given that dysbacteriosis of the intestinal flora is a key feature in the establishment of chronic inflammatory events, it is hoped that in the near future the microbiota-targeted therapies will be appropriate to design new cost-effective, physiological, animal-oriented IBD treatment strategies to be applied in a personalized manner.

Key words: animal, intestinal flora, mucosal immunity, inflammatory bowel diseases

CLC Number:

S856.4

LIU Sidi, MA Ben, ZHENG Yan, QIU Yunqiao, YAO Zelong, CAO Zhongzan, LUAN Xinhong. Research Progress in the Regulation of Intestinal Flora on Intestinal Mucosal Immunity and Inflammation in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1423-1431.

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Research Progress in the Regulation of Intestinal Flora on Intestinal Mucosal Immunity and Inflammation in Animals

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