表观遗传调控在畜禽脂肪沉积机制中的研究进展

doi:10.11843/j.issn.0366-6964.2023.03.001

摘要/Abstract

摘要： 表观遗传学是DNA序列没有发生改变，基因表达和表型产生可遗传的变化。前期研究发现，表观遗传调控参与多种生命活动过程，在脂肪沉积过程中也发挥重要的作用。脂肪沉积影响畜禽肉品质，研究脂肪沉积机制是畜禽育种中的一个重要方面。因此，本文从DNA甲基化、mRNA修饰、组蛋白修饰、染色体重塑和非编码RNA调控五个方面展开对畜禽脂肪沉积机制中研究进展的综述。

关键词: 表观遗传学, 脂肪沉积, DNA甲基化, mRNA修饰, 组蛋白修饰, 非编码RNA

Abstract: Epigenetic modifications are heritable changes in gene expression and phenotype without changing in the DNA sequence. Previous studies have shown that epigenetic regulation is involved in many life processes and plays an important role in fat deposition. Moreover, fat deposition is an important factor affecting the meat quality of livestock and poultry. Studying the mechanism of fat deposition is a significant aspect of breeding. In this review, the research progress of DNA methylation, mRNA modification, histone modification, chromosomal remodeling, and non-coding RNA regulation on the mechanism of fat deposition in livestock and poultry were summerized.

Key words: epigenetics, fat deposition, DNA methylation, mRNA modification, histone modification, non-coding RNA

中图分类号:

S852.23

金美林, 李桃桃, 孙东晓, 魏彩虹. 表观遗传调控在畜禽脂肪沉积机制中的研究进展[J]. 畜牧兽医学报, 2023, 54(3): 855-867.

JIN Meilin, LI Taotao, SUN Dongxiao, WEI Caihong. Research Progress of Epigenetic Regulation in Fat Deposition Mechanism of Livestock and Poultry[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 855-867.

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