动物早期胚胎发育中表观重编程的机制

doi:10.11843/j.issn.0366-6964.2023.12.002

摘要/Abstract

摘要： 哺乳动物早期胚胎发育过程中,受精卵经历了一系列表观遗传重编程事件,去除了雌雄原核的表观遗传记忆,从而建立了胚胎的全能性。然而,这些重编程事件的进行必须受到种属特异性的精确调控,而相关的调控机制仍需进一步研究。随着分子生物学技术的不断发展,特别是微量全基因组染色质分析技术的突破性进展,哺乳动物早期胚胎发育中的表观遗传重编程调控网络研究取得了重大进展。本文旨在介绍模式动物和多种家畜的表观遗传重编程机制的进展,包括DNA甲基化、组蛋白修饰、染色质开放性和染色质三维结构等方面的研究。

关键词: 早期胚胎发育, 表观遗传重编程, DNA甲基化, 组蛋白修饰, 染色质结构

Abstract: During mammalian early embryonic development, the fertilized egg undergoes a series of epigenetic reprogramming events, erasing the epigenetic memory of the parental nuclei and establishing the embryonic totipotency. However, the exact regulation of these reprogramming events by species-specific mechanisms calls for more research into the subject. Significant success has been made in understanding the regulatory network of epigenetic reprogramming during early mammalian embryonic development thanks to the ongoing development of molecular biology techniques, particularly the innovations in low-input whole-genome chromatin analysis. The goal of this paper is to outline recent developments in the mechanisms of epigenetic reprogramming in model animals and different livestock, including work on DNA methylation, histone modifications, chromatin accessibility, and chromatin 3D structure.

Key words: early embryonic development, epigenetic reprogramming, DNA methylation, histone modification, chromatin structure

中图分类号:

S814.6

张宸艺博, 余彤, 任斌斌, 郑睿智, 朱文治, 苏建民. 动物早期胚胎发育中表观重编程的机制[J]. 畜牧兽医学报, 2023, 54(12): 4898-4909.

ZHANG Chenyibo, YU Tong, REN Binbin, ZHENG Ruizhi, ZHU Wenzhi, SU Jianmin. Mechanism of Epigenetic Reprogramming of Early Animal Embryos[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 4898-4909.

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