捻转血矛线虫对伊维菌素的耐药机制

doi:10.11843/j.issn.0366-6964.2024.04.016

摘要/Abstract

摘要： 捻转血矛线虫病作为反刍动物最常见的消化道线虫疾病，已经给养殖业带来了重大经济损失，该寄生虫对伊维菌素早已经产生严重的耐药性，为该病的防治带来了一定的阻碍。在捻转血矛线虫对伊维菌素产生耐药性的研究进展中，已报道了3种可能耐药机制，分别为靶向GABA门控Cl^-通道、降低谷氨酸门控Cl^-开放频率和结合外排转运蛋白。调控型非编码RNA (miRNA和lncRNA) 在不同病原耐药性研究中相继报道，发现miRNA和lncRNA与P糖转运蛋白、细胞色素P450和GABA门控Cl^-通道等耐药机制相关。但是该非编码RNA在捻转血矛线虫对伊维菌素耐药性的研究中鲜有报道，所以要突破耐药性的问题，要将非编码RNA与已报道的可能耐药机制相关联，进行深入研究，找出关键的耐药靶点。本文主要总结了该病对伊维菌素耐药性机制的相关研究进展，为耐药性后续深入研究提供新的思路。

关键词: 捻转血矛线虫, 伊维菌素, 耐药性, 非编码RNA

Abstract: As the most common gastrointestinal nematode disease in ruminants, Haemonchus contortus disease has brought significant economic losses to the farming industry, and the parasite has long developed serious resistance to the commonly used anthelmintic drug ivermectin, which has brought some obstacles to the prevention and treatment of the disease. In the research progress of resistance to ivermectin in Haemonchus contortus, three possible resistance mechanisms have been reported, which are targeting GABA-gated Cl^- channels, decreasing the frequency of glutamate-gated Cl^- opening, and binding to exocytosis transporter proteins. With the development of science and technology, regulatory non-coding RNAs (miRNAs and lncRNAs) have been reported in drug resistance studies in different organisms, and miRNAs and lncRNAs have been found to be associated with resistance mechanisms such as P-glycosylated transporter proteins, cytochrome P450 and GABA-gated Cl^- channels. However, this non-coding RNA is rare in the study of Haemonchus contortus resistance to ivermectin, so to break through the resistance problem, the non-coding RNA should be correlated with the reported possible resistance mechanisms, and in-depth study should be conducted to find out the key resistance targets. In this paper, we mainly summarize the research progress related to the mechanism of resistance to ivermectin in this disease, which will provide new ideas for the subsequent in-depth study of drug resistance.

Key words: Haemonchus contortus, ivermectin, drug resistance, non-coding RNA

中图分类号:

S852.73

张艳敏, 赵东旭, 王文龙. 捻转血矛线虫对伊维菌素的耐药机制[J]. 畜牧兽医学报, 2024, 55(4): 1511-1520.

ZHANG Yanmin, ZHAO Dongxu, WANG Wenlong. Mechanism of Resistance to Ivermectin in the Haemonchus contortus[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1511-1520.

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