IGF2BP2介导的m6A修饰调控动物脂肪沉积的研究进展

doi:10.11843/j.issn.0366-6964.2023.09.002

摘要/Abstract

摘要： 随着人们生活水平的提高,近年来优质农业动物肉产品深受我国消费者市场青睐,而脂肪沉积是影响肉品质的重要因素。因此,阐明脂肪沉积的规律对探究动物优质肉品质形成的分子机理具有重要意义。N⁶-甲基腺苷修饰(m⁶A)是真核生物中含量最丰富的一种RNA表观遗传修饰,其与RNA运输、表达及降解等多种生物学事件密切相关。研究表明人胰岛素样生长因子2 mRNA结合蛋白2(IGF2BP2)介导的m⁶A修饰在动物脂肪沉积过程中发挥着关键作用,因此本文将论述m⁶A、IGF2BP2及其调控动物脂肪沉积的作用及分子机制研究进展,以期未来为家畜肉品质改良提供候选基因和科学依据。

关键词: m⁶A修饰, IGF2BP2, 脂肪沉积, 动物

Abstract: With the improvement of people's living standards, high-quality meat products of agricultural animal have been favored by consumers in China for the past few years. Fat deposition is an important factor affecting meat quality. Therefore, it is of great significance to clarify the molecular mechanism of high-quality meat formation. N⁶-methyladenylation modification (m⁶A) is the most abundant modifications in eukaryotic mRNA, which is related to the transport, expression, degradation process of RNA and is involved in regulating a variety of biological processes. Studies have shown that m⁶A modifications mediated by human insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) play a key role in animal fat deposition. This review will focus on m⁶A, IGF2BP2 and their role as well as molecular mechanism in animal fat deposition to provide candidate genes and scientific basis for the improvement of meat quality in the future.

Key words: m⁶A modification, IGF2BP2, fat deposition, animals

中图分类号:

S852.23

韩皓哲, 帖子航, 庞卫军, 蔡瑞. IGF2BP2介导的m⁶A修饰调控动物脂肪沉积的研究进展[J]. 畜牧兽医学报, 2023, 54(9): 3605-3612.

HAN Haozhe, TIE Zihang, PANG Weijun, CAI Rui. Advances of IGF2BP2-Mediated m⁶A Modification on Animal Fat Deposition[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3605-3612.

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IGF2BP2介导的m⁶A修饰调控动物脂肪沉积的研究进展

Advances of IGF2BP2-Mediated m⁶A Modification on Animal Fat Deposition

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