m6A修饰调控miRNAs影响细胞能量代谢的研究进展

doi:10.11843/j.issn.0366-6964.2026.01.008

Abstract

Abstract:

N6-methyladenosine （m⁶A） modification and microRNAs （miRNAs） are important factors in gene expression regulation， playing a crucial role in cellular energy metabolism. m⁶A modification participates in various physiological and pathological processes by regulating RNA stability， splicing and translation. miRNAs， as a class of small molecule RNAs， directly affect cellular metabolic pathways by targeting and regulating gene expression. The m⁶A modification-mediated regulation of miRNAs plays a pivotal role in cellular energy metabolism， especially in regulating metabolic processes such as glycolysis and mitochondrial function. By discussing the regulatory effect of m⁶A modification on miRNAs and its impact on energy metabolism， this review elaborating in detail on the mechanism by which m⁶A modification affects cellular energy metabolism by regulating miRNAs， and reveals the possibility of m⁶A modified miRNAs as targets for regulating cellular energy metabolism， in order to provide a theoretical reference for regulating animal growth and development and treating energy metabolism-related diseases.

Key words: m⁶A modification, miRNAs, energy metabolism, mitochondria

CLC Number:

S852.21

DENG Wenxin, LI Yihan, WANG Qian, ZHU Raoxi, LI Hanting, ZHANG Jiaojiao. Research Progress on m⁶A Modification Regulation of miRNAs Affecting Cellular Energy Metabolism[J]. Acta Veterinaria et Zootechnica Sinica, 2026, 57(1): 80-95.

Figures/Tables 4

Fig.1

Table 1

The role of m6A modification in regulating energy metabolism"

m⁶A调控因子 m⁶A regulators	m⁶A中的角色 Roles in m⁶A	机制 Mechanism	功能 Function	参考文献 Reference
METTL3	Writer	ACLY-SLC25A1	影响牙髓干细胞糖酵解	［38］
METTL3↓	Writer	Bcl-2↓，Bax↑，Caspaes-3↑	促进肺癌细胞的线粒体凋亡	［8］
METTL3↓	Writer	mTORC1↓	抑制肝癌细胞的糖酵解	［39］
METTL3	Writer	Wnt/β-catenin/c-Myc	促进成骨细胞的ATP合成	［66］
METTL3↑	Writer	HK2↑	促进子宫颈癌细胞的糖酵解	［67］
METTL3	Writer	lncRNA SNHG7/SRSF1/c-Myc	促进前列腺癌细胞的糖酵解	［68］
METTL14↑	Writer	GLUT3↑	促进成骨细胞的糖酵解	［42］
METTL14↑	Writer	AMPK↑	促进子宫颈癌细胞的糖酵解	［69］
WTAP↑	Writer	HK2↑	促进胃癌细胞的糖酵解	［43］
KIAA1429	Writer	lncRNA LINC00958/GLUT1	促进胃癌细胞的糖酵解	［44］
FTO↑	Eraser	FOXO1↑	影响2型糖尿病葡萄糖代谢	［48，50］
FTO↑	Eraser	G6PC↑	影响2型糖尿病葡萄糖代谢	［48］
FTO↓	Eraser	ATG16L1↑	抑制半月板细胞的ATP合成	［51］
FTO↑	Eraser	GLUT1-PKM2↑	促进肝癌细胞的糖酵解	［52］
FTO	Eraser	LINK-A/MCM3/HIF-1α	促进食管鳞状细胞癌细胞的糖酵解	［70］
ALKBH5↓	Eraser	PI3K/AKT↑	促进急性髓系白血病细胞能量代谢	［53］
ALKBH5↓	Eraser	CK2α↑	促进膀胱癌细胞的ATP合成	［54⁃55］
ALKBH5↓	Eraser	circNPIP1/miR-541-5P/PKM2↑	促进甲状腺乳头状癌细胞的糖酵解	［56］
ALKBH5↓	Eraser	circNPIP1/miR-3064-5P/PKM2↑	促进甲状腺乳头状癌细胞的糖酵解	［56］
YTHDF1	Reader	GLS1	促进结肠癌细胞的三羧酸循环	［58］
YTHDF1	Reader	LDHA	促进结肠癌细胞的糖酵解	［59］
YTHDF1	Reader	ENO1	促进肺腺癌细胞的糖酵解	［71］
YTHDF2	Reader	LATS1	促进乳腺癌细胞的糖酵解	［60］
YTHDF3	Reader	PFKL	促进肝癌细胞的糖酵解	［61］
YTHDC1	Reader	PTEN/PI3K/AKT	影响膀胱癌细胞代谢	［72］
IGF2BP1	Reader	LDHA	促进肾癌细胞的糖酵解	［65］
IGF2BP2	Reader	ACLY	影响牙髓干细胞的糖酵解	［38］
IGF2BP2/3	Reader	SLC25A1	影响牙髓干细胞的糖酵解	［38］
IGF2BP2	Reader	MYC	促进子宫颈癌细胞的糖酵解	［73］

Table 1

Table 2

Fig.2

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miRNA名称 miRNA name	靶基因通路 Target gene pathway	功能 Function	参考文献 Reference
miR-494-3p↑	PGC1-α↓	抑制脂肪细胞的能量代谢	［74］
miR-125a↑	HK2↓	抑制肝癌细胞的糖酵解	［75］
miR-125a↓	MFN2↑	抑制胰腺癌细胞的线粒体分裂	［76］
miR-125b↑	HK2↓	降低心肌细胞的糖代谢速率	［77］
miR-214↓	PTEN/AKT/mTOR/HK2↓	抑制非小细胞肺癌细胞的糖酵解	［78］
miR-214↓	PTEN/AKT/mTOR/PKM2↓	抑制非小细胞肺癌细胞的糖酵解	［78］
miR-150	SLC2A4/GLUT4	减弱心肌细胞的葡萄糖摄取	［79］
miR-223↑	GLUT4↑	增强心肌细胞的葡萄糖摄取	［80］
miR-34a-5p↑	LDHA↓，HK2↓，PKM2↓	抑制多囊卵巢综合征细胞的糖酵解	［81］
miR-486-5p↑	有丝分裂基因A相关激酶2↓	抑制结肠癌细胞的糖酵解	［82］
miR-195↑	Sirtuin 3/丙酮酸脱氢酶-ATP合酶↓	抑制心肌细胞有氧代谢及ATP合成	［83］
miR-152，miR-494，miR-19a	HIF-1α/柠檬酸合酶	影响肿瘤细胞的三羧酸循环	［84］

Research Progress on m⁶A Modification Regulation of miRNAs Affecting Cellular Energy Metabolism

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Research Progress on m6A Modification Regulation of miRNAs Affecting Cellular Energy Metabolism

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Research Progress on m⁶A Modification Regulation of miRNAs Affecting Cellular Energy Metabolism