细菌双组分系统的耐药性及致病性研究进展

doi:10.11843/j.issn.0366-6964.2025.07.008

Abstract

Abstract:

The bacterial two-component system (TCS) is a widespread signaling transduction pathway in organisms, which can sense and respond to physical, chemical, and biological stimuli inside and outside the cell, and induce a series of cellular responses through coupled sensing and regulatory mechanisms.TCS is the principal mechanism for bacteria to sense and respond to environmental signals and regulate physiological behaviors, which plays a crucial role in bacterial drug resistance, pathogenicity, biofilm formation, virulence factor regulation, etc.TCS regulates gene expression and cellular behaviors through the interactions of the two components (sensors and effectors) to handle the impact of adverse environment on bacteria, therefore achieving the goal of proliferation and invasion of the host.This paper reviews the research advances in the structure, function, drug resistance regulation and pathogenicity, and inhibitors of the two-component system, providing a reference for the development of novel antimicrobial drugs and bacterial prevention and control.

Key words: two-component system, structure, function, drug resistance, pathogenicity

CLC Number:

S852.61

XIANG Lingxian, JI Qianyu, SHAN Xinxin, LI Lin. Advances in the Study of Drug Resistance and Pathogenicity of Bacterial Two-component Systems[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(7): 3116-3128.

Figures/Tables 3

Fig. 1

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Table 1

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抑制剂 Inhibitors	作用部位 Region of action	抑制效应 Inhibition effect
传感器激酶抑制剂 Sensor kinase inhibitors
不饱和脂肪酸 Unsaturated fatty acids	KinA	自磷酸化 Auto-phosphorylation
卤代苯基噻唑 Halogenated phenylthiazole	AlgR2、VanS、CheA、NtrB	自磷酸化/磷酸转移 Auto-phosphorylation/phosphotransfer
水杨酰苯胺类 Salicylanilides, etc.	许多传感器激酶 Many sensor kinases	蛋白质聚集 Protein aggregation
噻吩并吡啶化合物 TEP	AlgR2	自磷酸化 Auto-phosphorylation
walkmycin B	WalKR	自磷酸化 Auto-phosphorylation
酪胺衍生物 Tyramine derivatives	VanSR	自磷酸化 Auto-phosphorylation
苯并恶唑嗪酮类 Benzoxazinones	许多传感器激酶 Many sensor kinases	自磷酸化 Auto-phosphorylation
RR抑制剂 Response regulator inhibitors
乳铁蛋白B Lactoferricin B	BasR、CreB	磷酸化 Phosphorylation
大黄酸 Rhein	PhoP	磷酸化 Phosphorylation
烷基咪唑衍生物 Alkyl imidazole derivatives	AlgR1	与靶DNA结合 Binding to target DNA
walrycin A walrycin B	AlgR1	与靶DNA结合 Binding to target DNA

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Advances in the Study of Drug Resistance and Pathogenicity of Bacterial Two-component Systems

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