牛病毒性腹泻病毒蛋白的免疫学特性以及相关疫苗研究进展

doi:10.11843/j.issn.0366-6964.2023.04.004

Abstract

Abstract: The prevalence of numerous genetic subtypes strains of bovine viral diarrhea virus (BVDV) and the expansion of its host spectrum interfere with the prevention and control of BVDV. European countries have adopted the measure of comprehensive detection and culling of BVDV-positive cattle and achieved a certain prevention and control effect, but considering the actual production situation in China, vaccination is still the optimal strategy. An in-depth understanding of the ‘game’ between BVDV proteins and the host immune system during virus infection will help researchers to effectively avoid the potential interference of antigen candidate proteins on immune effects in the term of vaccine development. In addition, vigorously developing low-cost, high-efficiency new-type vaccines (such as epitope peptide vaccine and virus-like particle vaccine) can enhance the biosafety of BVDV vaccines based on integrating viral immunodominant antigenic epitopes, and meet the requirements for the prevention and control of BVDV with vaccines. Thus, in order to provide proof-of-concept towards the development of BVDV vaccine and BVDV prevention and control, this paper reviews the researches on the immunological function and characteristics of BVDV proteins and the current situation of BVDV vaccine development.

Key words: bovine viral diarrhea virus (BVDV), BVDV proteins, vaccines, immunity

CLC Number:

S852.653

LI Yicong, PU Feiyang, FENG Xili, WANG Mengzhu, ZHAO Zeyang, ZHANG Derong, MA Zhongren, ZHOU Jianhua. Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1381-1391.

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Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines

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