猪链球菌耐药现状分析及感染防控措施

doi:10.11843/j.issn.0366-6964.2023.12.004

Abstract

Abstract: Streptococcus suis (S. suis) infection has long plagued the health and sustainable development of our pig industry. In particular, the emergence of drug-resistant strains will block the original prevention and control strategy of streptococcosis. The summary of the prevalence of resistance to S. suis at China and abroad in recent years can provide effective measures for the prevention and treatment of S. suis infection. Therefore, we first summarized the S. suis infection situation in large-scale pig farms at home and abroad in the past five years (most positive rate>40%). Among them, the serotype 2 strain is the most widespread in all provinces and cities in China. Subsequently, we summarized the epidemic status and infection characteristics of drug-resistant S. suis in pig farms, and found that drug-resistant S. suis in large-scale pig farms concentrated in the Asian and Europe, and the drug resistance exceeded 80% in the most regions, mainly tetracycline resistant strains. However, resistance to S. suis in large-scale pig farms in our country is mainly tetracycline and macrolide resistance. In addition, S. suis is a zoonotic agent that can cause systemic infection through the respiratory tract and blood. Finally, in view of the characteristics of S. suis strain variation, we proposed the importance of accurate detection for the prevention and control of S. suis, summarized the rapid detection methods. The prevention and control measures based on vaccination, combined drug use and the development of new host-directed antibiotics are emphasized to provide data support for the subsequent prevention and control of resistant strains of S. suis.

Key words: Streptococcus suis, drug resistance, prevention and control measures

CLC Number:

S852.611

Lü Ruoyi, SI Xiaohui, SUN Zhigang, SHI Xiaomin, LIU Xiaoye. Drug Resistance Situation of Streptococcus suis and Prevention Measures of Infections[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 4920-4933.

References

[1] WERTHEIM H F L, NGHIA H D T, TAYLOR W, et al. Streptococcus suis: an emerging human pathogen[J]. Clin Infect Dis, 2009, 48(5):617-625.
[2] HUANG Y T, TENG L J, HO S W, et al. Streptococcus suis infection[J]. J Microbiol Immunol Infect, 2005, 38(5):306-313.
[3] WALSH B, WILLIAMS A E, SATSANGI J. Streptococcus suis type 2: pathogenesis and clinical disease[J]. Rev Med Microbiol, 1992, 3:65-71.
[4] DE MOOR C E. Septicaemic infections in pigs, caused by haemolytic streptococci of new Lancefield groups designated R, S, and T[J]. Antonie Van Leeuwenhoek, 1963, 29:272-280.
[5] KILPPER-BÄLZ R, SCHLEIFER K H. Streptococcus suis sp. nov., nom. rev[J]. Int J Syst Evol Microbiol, 1987, 37(2):160-162.
[6] CHATELLIER S, HAREL J, ZHANG Y, et al. Phylogenetic diversity of Streptococcus suis strains of various serotypes as revealed by 16S rRNA gene sequence comparison[J]. Int J Syst Bacteriol, 1998, 48(2):581-589.
[7] OKURA M, OSAKI M, NOMOTO R, et al. Current taxonomical situation of Streptococcus suis[J]. Pathogens, 2016, 5(3):45.
[8] HU Y, FU S M, ZOU G, et al. Genome analysis provides insight into hyper-virulence of Streptococcus suis LSM178, a human strain with a novel sequence type 1005[J]. Sci Rep, 2021, 11(1):23919.
[9] 马婷婷, 朱远致, 闭璟珊, 等. 广西部分地区猪群中猪链球菌的分离鉴定及耐药性研究[J]. 畜牧与兽医, 2023, 55(2):103-109.MA T T, ZHU Y Z, ZHOU J S, et al. Isolation, identification and drug resistance of Streptococcus suis from pigs in some parts of the Guangxi area[J]. Animal Husbandry & Veterinary Medicine, 2023, 55(2):103-109. (in Chinese)
[10] CUONG N V, PADUNGTOD P, THWAITES G, et al. Antimicrobial usage in animal production: a review of the literature with a focus on low- and middle-income countries[J]. Antibiotics (Basel), 2018, 7(3):75.
[11] RAJKHOWA S, RAJESH J B. Virulence associated gene profiling and antimicrobial resistance pattern of Streptococcus suis isolated from clinically healthy pigs from north east India[J]. Lett Appl Microbiol, 2021, 73(3):392-397.
[12] KERDSIN A, TAKEUCHI D, NUANGMEK A, et al. Genotypic comparison between Streptococcus suis isolated from pigs and humans in Thailand[J]. Pathogens, 2020, 9(1):50.
[13] BESUNG I N K, SUARJANA I G K, AGUSTINA K K, et al. Isolation and identification of Streptococcus suis from sick pigs in Bali, Indonesia[J]. BMC Res Notes, 2019, 12(1):795.
[14] MA L C, ZHANG W J, MA J Y, et al. Genomic Insight into the antimicrobial resistance of Streptococcus Suis-six countries, 2011-2019[J]. China CDC Wkly, 2021, 3(47):994-998.
[15] CHEONG Y, OH C, LEE K, et al. Survey of porcine respiratory disease complex-associated pathogens among commercial pig farms in Korea via oral fluid method[J]. J Vet Sci, 2017, 18(3):283-289.
[16] SCHERRER S, ROSATO G, SPOERRY SERRANO N, et al. Population structure, genetic diversity and pathotypes of Streptococcus suis isolated during the last 13 years from diseased pigs in Switzerland[J]. Vet Res, 2020, 51(1):85.
[17] ZOUHAROVÁ M, ŠIMEK B, GEBAUER J, et al. Characterisation of Streptococcus suis isolates in the Czech Republic collected from diseased pigs in the years 2018-2022[J]. Pathogens, 2022, 12(1):5.
[18] NEDBALCOVA K, KUCHAROVICOVA I, ZOUHAROVA M, et al. Resistance of Streptococcus suis isolates from the Czech Republic during 2018-2022[J]. Antibiotics (Basel), 2022, 11(9):1214.
[19] LIANG P J, WANG M L, GOTTSCHALK M, et al. Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs[J]. Emerg Microbes Infect, 2021, 10(1):1960-1974.
[20] LACOUTURE S, OLIVERA Y R, MARIELA S, et al. Distribution and characterization of Streptococcus suis serotypes isolated from January 2015 to June 2020 from diseased pigs in Québec, Canada[J]. Can J Vet Res, 2022, 86(1):78-82.
[21] NICHOLSON T L, SHORE S M. Genome sequences of Streptococcus suis isolates obtained from pigs in the United States between 2015 and 2017[J]. Microbiol Resour Announc, 2022, 11(8):e0106721.
[22] ESTRADA A A, GOTTSCHALK M, ROSSOW S, et al. Serotype and genotype (Multilocus Sequence Type) of Streptococcus suis isolates from the United States serve as predictors of pathotype[J]. J Clin Microbiol, 2019, 57(9):e00377-19.
[23] MATAJIRA C E C, MORENO L Z, POOR A P, et al. Streptococcus suis in Brazil:genotypic, virulence, and resistance profiling of strains isolated from pigs between 2001 and 2016[J]. Pathogens, 2019, 9(1):31.
[24] 赵战勤, 王松华, 王臣, 等. 2011年~2015年河南省及其周边省份猪源链球菌流行病学调查[J]. 中国预防兽医学报, 2017, 39(10):845-847.ZHAO Z Q, WANG S H, WANG C, et al. Epidemiological investigation of Streptococcus suis in pigs from Henan region during 2011-2015[J]. Chinese Journal of Preventive Veterinary Medicine, 2017, 39(10):845-847. (in Chinese)
[25] 谭美芳, 谭佳, 曾艳兵, 等. 江西省5个规模化猪场健康猪群中猪链球菌的流行病学调查及耐药性研究[J]. 江西农业大学学报, 2020, 42(4):728-735.TAN M F, TAN J, ZENG Y B, et al. Epidemiological investigation and drug resistance analysis of Streptococcus suis in clinically healthy pigs from five large-scale pig farms in Jiangxi Province[J]. Acta Agriculturae Universitatis Jiangxiensis, 2020, 42(4):728-735. (in Chinese)
[26] 刘琪, 王娟, 周如月, 等. 广东地区健康猪群和发病猪群猪链球菌流行病学调查分析[J]. 中国畜牧兽医, 2017, 44(6):1825-1831.LIU Q, WANG J, ZHOU R Y, et al. The Streptococcus suis epidemiological analysis of healthy and infected swine in Guangdong Province[J]. China Animal Husbandry & Veterinary Medicine, 2017, 44(6):1825-1831. (in Chinese)
[27] 贺亚楠. 江苏部分地区2016年健康猪群猪链球菌流行病学调查[D]. 南京:南京农业大学, 2017.HE Y N. The epidemiological investigation of Streptococcus suis in healthy pigs in Jiangsu Province in 2016[D]. Nanjing:Nanjing Agricultural University, 2017. (in Chinese)
[28] 都玉, 刘召颖, 彭泽仁, 等. 重庆屠宰场猪链球菌感染的调查[J]. 畜牧与兽医, 2022, 54(6):58-65.DU Y, LIU Z Y, PENG Z R, et al. Investigation on Streptococcus suis infection in some slaughterhouses of Chongqing[J]. Animal Husbandry & Veterinary Medicine, 2022, 54(6):58-65. (in Chinese)
[29] 徐魁, 王巍, 文心田, 等. 四川主要养猪地区猪2型链球菌血清流行病学调查[J]. 中国预防兽医学报, 2017, 39(5):370-373.XU K, WANG W, WEN X T, et al. Epidemiological investigation of swine Streptococcus suis type 2 in Sichuan region[J]. Chinese Journal of Preventive Veterinary Medicine, 2017, 39(5):370-373. (in Chinese)
[30] 刘耀川, 高锋, 郭首龙, 等. 2016-2018年辽宁部分地区猪场猪链球菌2型流行病学及大环内酯类耐药基因携带情况调查[J]. 中国兽医杂志, 2020, 56(5):1-4, 10.LIU Y C, GAO F, GUO S L, et al. The investigation of epidemiology and macrolide resistance genes carrying condition of Streptococcus suis type 2 in Liaoning area from 2016 to 2018[J]. Chinese Journal of Veterinary Medicine, 2020, 56(5):1-4, 10. (in Chinese)
[31] 马婷婷. 2017年广西部分地区猪链球菌2、7、9型流行病学调查[D]. 南宁:广西大学, 2018.MA T T. Epidemiological survey of streptococcus suis serotype 2, 7, 9 in parts of Guangxi in 2017[D]. Nanning: Guangxi University, 2018. (in Chinese)
[32] ZHU H D, CHANG X J, ZHOU J Z, et al. Co-infection analysis of bacterial and viral respiratory pathogens from clinically healthy swine in Eastern China[J]. Vet Med Sci, 2021, 7(5):1815-1819.
[33] WANG M L, DU P C, WANG J P, et al. Genomic epidemiology of Streptococcus suis sequence type 7 sporadic infections in the Guangxi Zhuang autonomous region of China[J]. Pathogens, 2019, 8(4):187.
[34] 胡彬, 王建平, 徐迎春, 等. 山东省人感染猪链球菌基因组特征分析[J]. 中华预防医学杂志, 2021, 55(10):1232-1239.HU B, WANG J P, XU Y C, et al. Genomic investigation of human Streptococcus suis infection in Shandong Province[J]. Chi J Prev Med, 2021, 55(10):1232-1239. (in Chinese)
[35] 周淑琴, 孙韶华. 蓬莱市新发1例人感染猪链球菌病例流行病学调查[J]. 河南预防医学杂志, 2020, 31(12):928-930, 939.ZHOU S Q, SUN S H. Epidemiological investigation of a new case of human infection with Streptococcus suis in Penglai City[J]. Henan Journal of Preventive Medicine, 2020, 31(12):928-930, 939. (in Chinese)
[36] 赵梦娇, 张梦寒, 王小龙, 等. 江苏省苏州市1例人感染猪链球菌病例调查[J]. 疾病监测, 2018, 33(7):614-618.ZHAO M J, ZHANG M H, WANG X L, et al. Epidemiology and etiology of a case of human infection with Streptococcus suis in Suzhou, Jiangsu[J]. Disease Surveillance, 2018, 33(7):614-618. (in Chinese)
[37] 马涛, 刘艳, 王璇, 等. 南京市首例人感染猪链球菌病例调查[J]. 现代预防医学, 2019, 46(16):3042-3044.MA T, LIU Y, WANG X, et al. Investigation of the first human case infected with streptococcus suis in Nanjing[J]. Modern Preventive Medicine, 2019, 46(16):3042-3044. (in Chinese)
[38] 顾春艳, 朱海波, 陆明艳. 2019年盐城市盐都区1例人感染猪链球菌病例流行病学调查[J]. 江苏预防医学, 2019, 30(4):445-446.GU C Y, ZHU H B, LU M Y. Epidemiological investigation of a case of human infection with Streptococcus suis in Yandu District, Yancheng City, Yancheng City, China, 2019[J]. Jiangsu Journal of Preventive Medicine, 2019, 30(4):445-446. (in Chinese)
[39] 庞志峰, 章光明, 吴斌. 浙江省金华市首例人感染猪链球菌病流行病学调查[J]. 疾病监测, 2017, 32(8):700-702.PANG Z F, ZHANG G M, WU B. Epidemiological survey of the first human infection with Streptococcus suis in Jinhua, Zhejiang[J]. Disease Surveillance, 2017, 32(8):700-702. (in Chinese)
[40] 吕静, 潘浩, 朱敏慧, 等. 上海市闵行区首例人感染猪链球菌2型病例流行病及病原学调查[J]. 公共卫生与预防医学, 2020, 31(1):79-82.LYU J, PAN H, ZHU M H, et al. Epidemiological and pathogenic investigation on the first case of human streptococcus suis type 2 infection in Minhang District, Shanghai[J]. Journal of Public Health and Preventive Medicine, 2020, 31(1):79-82. (in Chinese)
[41] 王宇卓, 刘国良, 邱颖, 等. 河北省首例人感染猪链球菌病流行病学调查[J]. 医学动物防制, 2018, 34(1):59-60.WANG Y Z, LIU G L, QIU Y, et al. Epidemiological investigation of the first person infected with Streptococcus suis in Hebei Province[J]. Journal of Medical Pest Control, 2018, 34(1):59-60. (in Chinese)
[42] 林桢, 黄林光, 梁家习, 等. 广西巴马县人感染猪链球菌病2例死亡病例调查分析[J]. 医学动物防制, 2020, 36(10):996-998.LIN Z, HUANG L G, LIANG J X, et al. Investigation and analysis of two deaths of human Streptococcus suis disease in Bama County, Guangxi[J]. Journal of Medical Pest Control, 2020, 36(10):996-998. (in Chinese)
[43] 王福春, 黄德胜, 谢继杰. 广西靖西市一起人感染猪链球菌病疫情调查分析[J]. 医学动物防制, 2017, 33(9):962-964.WANG F C, HUANG D S, XIE J J. Analysis of Guangxi Jingxi City in 1 cases of human Streptococcus suis infection investigation[J]. Journal of Medical Pest Control, 2017, 33(9):962-964. (in Chinese)
[44] 邓茂铭, 石德慧, 郑颖, 等. 贵州省凯里市首例人感染猪链球菌病的流行病学调查[J]. 医学动物防制, 2017, 33(10):1107-1108.DENG M M, SHI D H, ZHENG Y, et al. Guizhou kaili case of the first human infection with swine Streptococcus suis epidemiological investigation[J]. Journal of Medical Pest Control, 2017, 33(10):1107-1108. (in Chinese)
[45] VARELA N P, GADBOIS P, THIBAULT C, et al. Antimicrobial resistance and prudent drug use for Streptococcus suis[J]. Anim Health Res Rev, 2013, 14(1):68-77.
[46] DÍEZ DE LOS RÍOS J, REYNAGA E, GARCÍA-GONZÀLEZ M, et al. Clinical and epidemiological characteristics of Streptococcus suis infections in Catalonia, Spain[J]. Front Med (Lausanne), 2021, 8:792233.
[47] RENZHAMMER R, LONCARIC I, LADSTÄTTER M, et al. Detection of various Streptococcus spp. and their antimicrobial resistance patterns in clinical specimens from Austrian swine stocks[J]. Antibiotics (Basel), 2020, 9(12):893.
[48] O’DEA M A, LAIRD T, ABRAHAM R, et al. Examination of Australian Streptococcus suis isolates from clinically affected pigs in a global context and the genomic characterisation of ST1 as a predictor of virulence[J]. Vet Microbiol, 2018, 226:31-40.
[49] WERINDER A, ASPÁN A, BACKHANS A, et al. Streptococcus suis in Swedish grower pigs: occurrence, serotypes, and antimicrobial susceptibility[J]. Acta Vet Scand, 2020, 62(1):36.
[50] SOARES T C S, PAES A C, MEGID J, et al. Antimicrobial susceptibility of Streptococcus suis isolated from clinically healthy swine in Brazil[J]. Can J Vet Res, 2014, 78(2):145-149.
[51] YONGKIETTRAKUL S, MANEERAT K, ARECHANAJAN B, et al. Antimicrobial susceptibility of Streptococcus suis isolated from diseased pigs, asymptomatic pigs, and human patients in Thailand[J]. BMC Vet Res, 2019, 15(1):5.
[52] DONG X X, CHAO Y, ZHOU Y J, et al. The global emergence of a novel Streptococcus suis clade associated with human infections[J]. EMBO Mol Med, 2021, 13(7):13810.
[53] ZHANG B Z, KU X, YU X X, et al. Prevalence and antimicrobial susceptibilities of bacterial pathogens in Chinese pig farms from 2013 to 2017[J]. Sci Rep, 2019, 9(1):9908.
[54] TAN M F, TAN J, ZENG Y B, et al. Antimicrobial resistance phenotypes and genotypes of Streptococcus suis isolated from clinically healthy pigs from 2017 to 2019 in Jiangxi Province, China[J]. J Appl Microbiol, 2021, 130(3):797-806.
[55] DONG C L, CHE R X, WU T, et al. New characterization of multi-drug resistance of Streptococcus suis and biofilm formation from swine in Heilongjiang Province of China[J]. Antibiotics (Basel), 2023, 12(1):132.
[56] ICHIKAWA T, OSHIMA M, YAMAGISHI J, et al. Changes in antimicrobial resistance phenotypes and genotypes in Streptococcus suis strains isolated from pigs in the Tokai area of Japan[J]. J Vet Med Sci, 2020, 82(1):9-13.
[57] WANG Y, WANG Y X, SUN L Y, et al. Streptococcus suis biofilm:regulation, drug-resistance mechanisms, and disinfection strategies[J]. Appl Microbiol Biotechnol, 2018, 102(21):9121-9129.
[58] 杨艳北, 许晶, 刘婉萍, 等. 低浓度阿奇霉素对猪链球菌2型蛋白表达、荚膜多糖与药物敏感性的影响[J]. 畜牧兽医学报, 2023, 54(2): 757-765.YANG Y B, XU J, LIU W P, et al. Effects of low-concentration azitromycin on protein expression, capsular polysaccharides and drug susceptibility of Streptococcus suis Type 2[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2):757-765. (in Chinese(
[59] 范雪, 邵伟, 赵艳坤, 等. 无乳链球菌毒力基因与耐药性的相关性研究进展[J]. 中国畜牧兽医, 2021, 48(1):375-384.FAN X, SHAO W, ZHAO Y K, et al. Research progress on the correlation between virulence genes and drug resistance of Streptococcus agalactiae[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(1):375-384. (in Chinese)
[59] ZHANG C Y, ZHANG P, WANG Y, et al. Capsular serotypes, antimicrobial susceptibility, and the presence of transferable oxazolidinone resistance genes in Streptococcus suis isolated from healthy pigs in China[J]. Vet Microbiol, 2020, 247:108750.
[60] 韩宁, 李杰, 陈佳文, 等. 广东省某猪场链球菌的分离鉴定及耐药性分析[J]. 中国兽医学报, 2022, 42(7):1405-1410.HAN N, LI J, CHEN J W, et al. Identification and resistance of Streptococcus from a pig farm in Guangdong Province[J]. Chinese Journal of Veterinary Science, 2022, 42(7):1405-1410. (in Chinese)
[61] 刘宝玲, 楚品品, 李春玲, 等. 猪链球菌临床分离株对四环素类抗生素的耐药性和耐药基因分析[J]. 中国畜牧兽医, 2022, 49(7):2796-2804.LIU B L, CHU P P, LI C L, et al. Analysis of resistance and resistance genes of Streptococcus suis clinical isolates to tetracyclines[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(7):2796-2804. (in Chinese)
[62] HADJIRIN N F, MILLER E L, MURRAY G G R, et al. Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis[J]. BMC Biol, 2021, 19(1):191.
[63] ARNDT E R, FARZAN A, MACINNES J I, et al. Antimicrobial resistance of Streptococcus suis isolates recovered from clinically ill nursery pigs and from healthy pigs at different stages of production[J]. Can Vet J, 2019, 60(5):519-522.
[64] NICHOLSON T L, BAYLES D O. Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the United States[J]. Front Microbiol, 2022, 13:1043529.
[65] YONGKIETTRAKUL S, WONGSURAWAT T, JENJAROENPUN P, et al. Genome sequences of antibiotic-resistant Streptococcus suis strains isolated from human patients and diseased and asymptomatic pigs in Thailand[J]. Infect Genet Evol, 2021, 87:104674.
[66] LI L L, ZHANG Q, ZHAO X N, et al. Rapid detection of mrp, epf, and sly genes by loop-mediated isothermal amplification in Streptococcus suis[J]. Foodborne Pathog Dis, 2021, 18(4):290-296.
[67] CLOUTIER G, D’ALLAIRE S, MARTINEZ G, et al. Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease[J]. Vet Microbiol, 2003, 97(1-2):135-151.
[68] ARENDS J P, ZANEN H C. Meningitis caused by Streptococcus suis in humans[J]. Rev Infect Dis, 1988, 10(1):131-137.
[69] ZHU Y J, ZHU F, BO L H, et al. A rare case of meningitis and septicemia caused by Streptococcus suis in a woman without a history of live pig contact or eating raw pork[J]. Braz J Microbiol, 2021, 52(4):2007-2012.
[70] FONGCOM A, PRUKSAKORN S, MONGKOL R, et al. Streptococcus suis infection in northern Thailand[J]. J Med Assoc Thai, 2001, 84(10):1502-1508.
[71] 韩瑞, 杨行, 张文波, 等. 猪链球菌自溶素的原核表达及其抗体间接ELISA检测方法的建立[J]. 中国畜牧兽医, 2022, 49(9):3508-3519. HAN R, YANG X, ZHANG W B, et al. Prokaryotic expression of autolysin from Streptococcus suis and establishment of an indirect ELISA method for detection of its antibody[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(9):3508-3519. (in Chinese)
[72] 乔宏, 龚俊, 栾慧, 等. 基于溶菌酶释放蛋白的猪链球菌间接ELISA抗体检测方法的建立[J]. 中国预防兽医学报, 2020, 49(9):912-917.QIAO H, GONG J, LUAN H, et al. Establishment of indirect-ELISA method for detection of swine strepto coccosis based on muramidase release protein[J]. Chinese Journal of Preventive Veterinary Medicine, 2020, 49(9):912-917. (in Chinese)
[73] 李建达, 于江, 张玉玉, 等. 猪链球菌2型实时荧光定量PCR检测方法的建立与应用[J]. 中国畜牧兽医, 2016, 43(12):3107-3113.LI J D, YU J, ZHANG Y Y, et al. Establishment and application of quantitative real-time PCR method to detect Streptococcus suis serotype 2[J]. China Animal Husbandry and Veterinary Medicine, 2016, 43(12):3107-3113. (in Chinese)
[74] 刘艳艳, 吕婷婷, 吴家强, 等. 猪链球菌和猪多杀性巴氏杆菌多重实时荧光PCR方法的建立[J]. 微生物学通报, 2022, 49(12):5112-5125.LIU Y Y, LV T T, WU J Q, et al. Establishment of a multiplex real-time fluorescent PCR method for simultaneous detection of Streptococcus suis and Pasteurella multicide[J]. Microbiology China, 2022, 49(12):5112-5125. (in Chinese)
[75] 吴静波, 南文金, 黄健强, 等. 猪链球菌通用型和2型双重荧光定量PCR快速检测技术的建立和应用[J]. 畜牧兽医学报, 2018, 49(2): 368-377.WU J B, NAN W J, HUANG J Q, et al. Development of a rapid duplex real-time pcr assay for Streptococcus suis and S. suis serotype 2[J]. Acta Veterinaria et Zootechnica Sinica, 2018, 49(2): 368-377. (in Chinese)
[76] ARAI S, TOHYA M, YAMADA R, et al. Development of loop-mediated isothermal amplification to detect Streptococcus suis and its application to retail pork meat in Japan[J]. Int J Food Microbiol, 2015, 208:35-42.
[77] 席小燕, 陈家享, 梁嘉雯, 等. 猪链球菌2型HNB-LAMP检测方法的建立[J]. 韶关学院学报:自然科学, 2022, 43(12):50-54.XI X Y, CHEN J X, LIANG J W, et al. Development of HNB-LAMP to detect Streptococcus suis serotype 2[J]. Journal of Shaoguan University: Natural Science, 2022, 43(12):50-54. (in Chinese)
[78] JIANG X W, ZHU L X, ZHAN D B. Development of a recombinase polymerase amplification assay for rapid detection of Streptococcus suis type 2 in nasopharyngeal swab samples[J]. Diagn Microbiol Infect Dis, 2022, 102(2):115594.
[79] 张闪闪, 何斌, 李书光, 等. 可视化RPA-LFD技术快速检测猪链球菌[J]. 畜牧兽医学报, 2022, 53(2):538-547.ZHANG S S, HE B, LI S G, et al. Rapid detection of Streptococcus suis with visual RPA-LFD technology[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2):538-547. (in Chinese)
[80] YI L, FAN Q Y, WANG Y X, et al. Evaluation of immune effect of Streptococcus suis biofilm-associated protein PDH[J]. Vet Microbiol, 2021, 263:109270.
[81] SEGURA M, ARAGON V, BROCKMEIER S L, et al. Update on Streptococcus suis research and prevention in the era of antimicrobial restriction:4th international workshop on S. suis[J]. Pathogens, 2020, 9(5):374.
[82] GAO T, YE F, YUAN F Y, et al. Green tea polyphenols inhibit growth, pathogenicity and metabolomics profiles of Streptococcus suis[J]. Microb Pathog, 2022, 164:105421.
[83] SHEN X, NIU X D, LI G, et al. Amentoflavone ameliorates Streptococcus suis-induced infection in vitro and in vivo[J]. Appl Environ Microbiol, 2018, 84(24):e01804-18.
[84] 王金玉, 姜晓文, 王娜, 等. 穿心莲内酯影响猪链球菌生物被膜形成[J]. 畜牧兽医学报, 2018, 49(3):629-636. WANG J Y, JIANG X W, WANG N, et al. Effect of andrographolide on the biofilm formation of Streptococcus suis[J]. Acta Veterinaria et Zootechnica Sinica, 2018, 49(3):629-636. (in Chinese)
[85] LIU X Y, LIU F, DING S Y, et al. Sublethal levels of antibiotics promote bacterial persistence in epithelial cells[J]. Adv Sci (Weinh), 2020, 7(18):1900840.
[86] DE AGUIAR F C, SOLARTE A L, TARRADAS C, et al. Combined effect of conventional antimicrobials with essential oils and their main components against resistant Streptococcus suis strains[J]. Lett Appl Microbiol, 2019, 68(6):562-572.
[87] TRAM G, JENNINGS M P, BLACKALL P J, et al. Streptococcus suis pathogenesis—a diverse array of virulence factors for a zoonotic lifestyle[J]. Adv Microb Physiol, 2021, 78:217-257.
[88] YU Y, FANG J T, ZHENG M, et al. Combination therapy strategies against multiple-resistant Streptococcus Suis[J]. Front Pharmacol, 2018, 15(9):489.
[89] HE S W, DENG Q, LIANG B B, et al. Suppressing alpha-hemolysin as potential target to screen of flavonoids to combat bacterial coinfection[J]. Molecules, 2021, 26(24):7577.
[90] BERCIER P, GOTTSCHALK M, GRENIER D. Streptococcus suis suilysin compromises the function of a porcine tracheal epithelial barrier model[J]. Microb Pathog, 2020, 139:e103913.
[91] 贺尚文, 侯思鲁, 李秋月, 等. 黄酮类中药抗细菌溶血素研究进展[J]. 中国兽医学报, 2021, 41(3):611-617.HE S W, HOU S L, LI Q Y, et al. Advance in the study of Chinese herbal medicine against bacterial hemolysin[J]. Chinese Journal of Veterinary Science, 2021, 41(3):611-617. (in Chinese)
[92] BONIFAIT L, VEILLETTE M, LETOURNEAU V, et al. Detection of Streptococcus suis in bioaerosols of swine confinement buildings[J]. Appl Environ Microbiol, 2014, 80(11):3296-3304.
[93] TAWK C, NIGRO G, LOPES I R, et al. Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens[J]. EMBO J, 2018, 37(23):e98529.
[94] 刘晓晔, 毛畅思, 朱奎. 宿主导向抗菌药物的研究进展[J]. 中国动物传染病学报, 2021, 29(4):52-60.LIU X Y, MAO C S, ZHU K. Progress on host-acting antibacterial drugs[J]. Chinese Journal of Animal Infectious Diseases, 2021, 29(4):52-60. (in Chinese)
[95] LIU X Y, WU Y F, MAO C S, et al. Host-acting antibacterial compounds combat cytosolic bacteria[J]. Trends Microbiol, 2022, 30(8):761-777.
[96] SUBRAMANIAN K, IOVINO F, TSIKOURKITOUDI V, et al. Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease[J]. Embo Mol Med, 2020, 12(11):e12695.
[97] ABRAMS M E, JOHNSON K A, PERELMAN S S, et al. Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol[J]. Nat Microbiol, 2020, 5(7):929-942.
[98] GOYETTE-DESJARDINS G, AUGER J P, XU J G, et al. Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing[J]. Emerg Microbes Infect, 2014, 3(1):1-20.
[99] ZHOU Y, YAN K, SUN C F, et al. Binding of plasminogen to Streptococcus suis protein endopeptidase O facilitates evasion of innate immunity in Streptococcus suis[J]. Front Microbiol, 2021, 12:694103.
[100] PIAN Y, LI X Q, ZHENG Y L, et al. Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a α_Xβ₂ integrin-dependent manner[J]. Sci Rep, 2016, 6:26966.
[101] LIU F, LI J Q, YAN K, et al. Binding of fibronectin to SsPepO facilitates the development of Streptococcus suis meningitis[J]. J Infect Dis, 2018, 217(6):973-982.
[102] MUSYOKI A M, SHI Z Y, XUAN C L, et al. Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from gram-positive bacterium Streptococcus suis[J]. Proc Natl Acad Sci USA, 2016, 113(48):13869-13874.

Drug Resistance Situation of Streptococcus suis and Prevention Measures of Infections

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LIU Xinhuan, YUN Jialei, MAO Li, LI Jizong, HAO Fei, HE Miaofeng, YANG Leilei, ZHANG Wenwen, CHENG Zilong, SUN Min, LIU Maojun, WANG Shaohui, BAI Juan, LI Wenliang. Isolation, Identification, Virulence Genes and Drug Resistance Analysis of Escherichia coli Isolated from Diarrheal Goat and Sheep [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3445-3454.
[2]	ZHAO Feifei, LI Jie, HAN Ning, XIE Shiting, ZENG Zhenling. Antibacterial Drug Resistance Analysis of Klebsiella pneumoniae Isolated from Slaughterhouse [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 3044-3053.
[3]	YANG Yanbei, XU Jing, LIU Wanping, TAO Aini, FENG Yulin, SUN Yong, WANG Chuang, LIU Jian. Effects of Low-concentration Azitromycin on Protein Expression, Capsular Polysaccharides and Drug Susceptibility of Streptococcus suis Type 2 [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 757-765.
[4]	WANG Jianing, ZHANG Ziqiang, KONG Dejing, FENG Caicai, ZHANG Feike, LIU Yumei. Isolation and Identification of Klebsiella pneumoniae in Rabbits [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5198-5206.
[5]	ZHANG Kaichuan, WANG Jinyu, LI Shoujun, JIA Kun. Isolation, Identification and Biological Characteristics of Klebsiella pneumoniae from Sheep in Guangdong Province [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 328-337.
[6]	TONG Panpan, HUANG Shunmin, WANG Yudan, SHI Xuhui, CHEN Wenxia, SONG Xinlong, ZHANG Yi, SU Zhanqiang, XIE Jinxin. Phylogenetic Clustering, Serotype and Drug Resistance Analysis of Escherichia coli from Diarrhea with Piglets in Xinjiang [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 414-420.
[7]	YU Yongfeng, QUAN Heng, DONG Wenhao, ZOU Ronghua, WU Xiaoni, GONG Xiaowei, CHEN Qiwei. The Mechanism of Two-component Regulatory System Mediating Drug Resistance of Gram-negative Bacteria [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1689-1701.
[8]	WANG Xi, LI Ke, LI Tingcui, YAN Hongya, ZHAO Rong, CHANG Zhishun, LIAO Ming, SUN Minhua, XIN Aiguo. MLST Typing and Drug Resistance Analysis of 75 Salmonella Strains Isolated from Laying Hens [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1626-1631.
[9]	ZHANG Lin, LU Fang, FU Hengfeng, JIANG Xidi, WEI Qiling, QI Caili, GAO Haixia, LI Lin. Regulation Mechanism of BaeSR on Fluoroquinolones Resistance in Salmonella Typhimurium [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(3): 894-903.
[10]	ZHANG Shanshan, HE Bin, LI Shuguang, LIU Mingcheng, JIANG Jinqing, HU Jianhe, LEI Liancheng, SHEN Zhiqiang, XIA Xiaojing. Rapid Detection of Streptococcus suis with Visual RPA-LFD Technology [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2): 538-547.
[11]	LI Huaming, XIANG Wei, LU Wenbing, LIU Feng, LEI Liancheng, ZHANG Fuxian. Pathogenicity and Drug Sensitivity Analysis of a Porcine Klebsiella pneumoniae Type ST-35 [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(12): 4356-4366.
[12]	HONG Mian, HUANG Jiamin, CHEN Dongmei, XIE Shuyu. Research Progress of Nanotechnology to Enhance Antibacterial Efficacy of Antibacterial Drugs [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3731-3736.
[13]	JIANG Kai, ZHAO Pengyu, WANG Tianshuo, YU Siwen, BI Lan, XIAO Jiawei, HE Xianjing, GUO Donghua. Analysis of Biological Characteristics of Fusobacterium necrophorum 43K OMP Genes Mutant Strain [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 4019-4026.
[14]	HAN Xuejiao, LI Liang, ZHAN Songhe, DUAN Qianqian, CUI Lirong, LIU Xuelan, SUN Pei, WEI Jianzhong, LI Yu. Effects of Prophage on Virulence, Environmental Adaptability, Drug Resistance and Metabolic Activity of Streptococcus suis [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 290-303.
[15]	GAO Yuan, WANG Lanqian, ZHANG Lina, FU Ying, ZHANG Jianmin, LIAO Ming, QU Xiaoyun. Characterization of Prevalence and Antimicrobial Resistance of Salmonella Enterica Serovar London from Markets in Guangzhou [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(2): 488-497.