双组分调控系统介导革兰阴性菌耐药的作用机制

doi:10.11843/j.issn.0366-6964.2022.06.004

Abstract

Abstract: Bacterial resistance has become a key problem to be solved in clinical practice, especially the drug resistance caused by Gram-negative bacteria, which bring great challenges to clinical treatment. It is particularly important to clarify the regulatory mechanism of complex drug resistance phenotypes of important bacteria as soon as possible. Two-component regulatory systems (TCS) exist in a variety of Gram-negative bacteria and play important roles in the life activities of bacteria. TCS is one of the principal mechanisms by which bacteria perceive environmental changes and produce corresponding regulations. TCS is usually composed of two proteins, including sensor proteins (usually histidine kinases) and responsive regulatory proteins (usually transcription factors). Both of them can integrate the environmental signals of bacteria, regulate gene expression and change the physiological behavior of bacteria through phosphorylation-mediated synergy. The response mechanism studies of TCS-mediated drug resistance have become a new research hotspot recently. In this paper, the structural basis and mechanism of TCS-mediated drug resistance of clinically important Gram-negative bacteria were reviewed. It would be enhancing the comprehensive understanding of the bacterial TCS system and provide new ideas and strategies for the scientific research and development of drugs in the future.

Key words: two-component regulatory systems (TCS), stimulus signal, bacterial drug resistance, transcriptional regulation

CLC Number:

S852.61

YU Yongfeng, QUAN Heng, DONG Wenhao, ZOU Ronghua, WU Xiaoni, GONG Xiaowei, CHEN Qiwei. The Mechanism of Two-component Regulatory System Mediating Drug Resistance of Gram-negative Bacteria[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1689-1701.

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The Mechanism of Two-component Regulatory System Mediating Drug Resistance of Gram-negative Bacteria

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