二甲氧苄啶在鸡排泄物中的排泄研究

doi:doi: 10.11843/j.issn.0366-6964.2016.08.020

Abstract

Abstract:

A high performance liquid chromatography (HPLC) method was developed for the determination of diaveridine in chicken excreta to explore excretion regularity of diaveridine in chicken excreta.Twenty healthy white feather broiler chickens were randomly divided into 2 groups of 10 chickens each，the 2 groups were orally administered at a dosage of 10，20 mg•kg^－1 body weight of diaveridine，respectively.The all excreta of chicken were collected at 2，4，8，16，24，32，48，72 h，respectively.The concentration of diaveridine was analyzed by HPLC.Diaveridine was excreted quickly with excreta after oral administration.The total recovery of diaveridine was 21.63% at a dosage of 10 mg•kg^－1 body weight and 24.13% at a dosage of 20 mg•kg^－1 body weight，respectively.The results indicate that prototype drug of diaveridine in chicken is incompletely excreted，and there probably exist other metabolites and glucuronide conjugates of prototype drug in the excreta.

CLC Number:

S859.7

WANG Jia-peng，CHEN Hong，LIU Hai-sheng，QUAN Dan，ZHOU Yu-hui，PAN Li-hua，ZENG Zhen-ling. Studies on Excretion of Diaveridine in Chicken Excreta[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(8): 1682-1688.

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Studies on Excretion of Diaveridine in Chicken Excreta

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