常山酮抗原虫作用研究进展

doi:10.11843/j.issn.0366-6964.2023.03.007

Abstract

Abstract: Parasitic diseases are the most destructive and pervasive infectious diseases in the world, killing tens of thousands of people annually and causing huge economic losses. Halofuginone is a halogenated derivative of febrifugine isolated and extracted from the plant Changshan, which has strong antiprotozoal activity. Compared with febrifugine, halofuginone has less toxic and side effects, which makes it more advantageous in disease treatment. In recent years, the biological activities of halofuginone in cancer, fibrosis and autoimmune diseases have attracted extensive attention. In human clinical practice, the research on the effects of halofuginone on Duchenne muscular dystrophy and solid tumors has entered the stage of clinical trials. In veterinary clinical practice, halofuginone hydrobromide and halofuginone lactate have been authorized by the FDA and the EU for the prevention and treatment of poultry coccidiosis and ruminant cryptosporidiosis, respectively. Moreover, halofuginone also has efficient inhibition on protozoa parasites such as Plasmodium, Toxoplasma, Theileria, and Leishmania. Aminoacyl-tRNA synthetases are emerging targets for the treatment of parasitic diseases, this review summarizes the effect of halofuginone on various protozoa parasites and the related mechanisms of inhibiting prolyl-tRNA synthetase, and hope to provide a reference for the subsequent theoretical research and clinical application of halofuginone antiprotozoal.

Key words: halofuginone, parasitic diseases, protozoa, prolyl-tRNA synthetase

CLC Number:

S859.795

LIN Mengjuan, GAO Shasha, ZHAO Xingchen, ZHONG Yuxin, WU Jun, ZHANG Junren, GUO Dawei. Research Progress on Antiprotozoal Activity of Halofuginone[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 924-933.

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Research Progress on Antiprotozoal Activity of Halofuginone

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